Firefighting, per‐ and polyfluoroalkyl substances, and DNA methylation of genes associated with prostate cancer risk

Prostate cancer is the leading incident cancer among men in the United States. Firefighters are diagnosed with this disease at a rate 1.21 times higher than the average population. This increased risk may result from occupational exposures to many toxicants, including per‐ and polyfluoroalkyl substa...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2024-01, Vol.65 (1-2), p.55-66
Hauptverfasser:	Quaid, Margaret, Goodrich, Jaclyn M., Calkins, Miriam M., Graber, Judith M., Urwin, Derek, Gabriel, Jamie, Caban‐Martinez, Alberto J., Petroff, Rebekah L., Grant, Casey, Beitel, Shawn C., Littau, Sally, Gulotta, John J., Wallentine, Darin, Hughes, Jeff, Burgess, Jefferey L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers CpG islands Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics environmental exposures Epigenetics Exposure Fire departments Fire fighting Firefighters firefighting Fluorocarbons - analysis Fluorocarbons - toxicity Genomics Glutathione transferase Health risks Humans Male Mathematical models Neoplasm Proteins Occupational Exposure - adverse effects Occupational hazards Occupational health Perfluoroalkyl & polyfluoroalkyl substances Perfluorochemicals Prostate cancer Prostatic Neoplasms - epidemiology Prostatic Neoplasms - genetics Serum levels Statistical analysis Statistical models Toxicants
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