PPARα/δ dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells

[Display omitted] Diabetic kidney disease (DKD) is responsible for nearly half of all end-stage kidney disease and kidney failure is a major driver of mortality among patients with diabetes. To date, few safe and effective drugs are available to reverse the decline of kidney function. Kidney tubules...

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Veröffentlicht in:	Biochemical pharmacology 2024-04, Vol.222, p.116076, Article 116076
Hauptverfasser:	Ke, Qingqing, Xiao, Yu, Liu, Dandan, Shi, Caifeng, Shen, Rui, Qin, Songyan, Jiang, Lei, Yang, Junwei, Zhou, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Branch chain amino acid degradation Diabetic kidney disease Fatty acid metabolism Glycolysis Kidney tubular cells Peroxisome proliferator-activated receptors
Online-Zugang:	Volltext
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