Inflammatory bowel disease evolution in the past two decades: a chronological multinational study
The multifactorial nature of inflammatory bowel disease (IBD), which manifests differently in individuals creates a need for a better understanding of the behaviour and pattern of the disease due to environmental factors. The current study aimed to study the changes in IBD behaviour, presentation, a...
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| creator | Alavinejad, Pezhman Hashemi, Seyed Jalal Behl, Nitin Hormati, Ahmad Elbasuny, Abubakr Daryani, Naser Ebrahimi Modarres, Mehdi Pezeshgi Arshadzadeh, Masoud Panahande, Samira Hang, Dao Viet Mahros, Aya Mohammed Parsi, Abazar Javaherizadeh, Hazhir Rehman, Ata Pawlak, Katarzyna M. Ahmadi, Mitra Ahmed, Mohammed Hussien Farsi, Farnaz Arefi, Mohammad Quadri, Afreen Tran, Quang Trung Alborzi, Foroogh Amin Alavi, Seyed Mohammad Cheraghian, Bahman Ramezani, Elmira Gouda, Mohammed Fathi Saadati, Babak Quadri, Ahmed Alam Hirani, Rahim Maher, Maha Ghoneem, Elsayed |
| description | The multifactorial nature of inflammatory bowel disease (IBD), which manifests differently in individuals creates a need for a better understanding of the behaviour and pattern of the disease due to environmental factors. The current study aimed to study the changes in IBD behaviour, presentation, and characteristics in patients over the past two decades with a goal of improving patients’ diagnosis, management and outcomes.
During a 6-month period (1/02/2022–30/07/2022), the information of patients with IBD who attended IBD outpatient clinics of 11 referral centre's in six countries was collected, and based on the first time of diagnosis with IBD, they were allocated as group A (those who were diagnosed more than 15 years ago), group B (those who were diagnosed with IBD between 5 and 15 years ago) and group C (IBD cases who diagnosed in recent 5 years). Then the most prevalent subtypes and characters of the disease are evaluated and compared to make clear if the presenting pattern and behaviour of the disease has changed in the last 2 decades.
Overall 1430 patients with IBD including 1207 patients with ulcerative colitis (UC) (84.5%) and 205 patients with Crohn's disease (CD; 14.3%) included. Mean age of participants at the first time of diagnosis with IBD was 30 years. The extra-intestinal involvement of IBD in groups A and B was more prevalent in comparison with group C. Most of those in groups A & B had academic education but in group C, the most prevalent educational status was high school or diploma (P = 0.012). In contrast to groups A and B, the relative prevalence of medium socioeconomic level in group C had decreased (65%). Relative prevalence of UC subtypes was similar among groups A and B (extensive colitis as most prevalent) but in group C, the most prevalent subtype is left side colitis (38.17%). The most prevalent subtype of CD in groups A and B was ileocolic involvement while in group C, upper GI involvement is significantly increased. The rate of food sensitivity among groups A and B was more than group C (P = 0.00001). The relative prevalence of patients with no flare has increased with a steady slope (P |
| doi_str_mv | 10.1016/j.eclinm.2024.102542 |
| format | Article |
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During a 6-month period (1/02/2022–30/07/2022), the information of patients with IBD who attended IBD outpatient clinics of 11 referral centre's in six countries was collected, and based on the first time of diagnosis with IBD, they were allocated as group A (those who were diagnosed more than 15 years ago), group B (those who were diagnosed with IBD between 5 and 15 years ago) and group C (IBD cases who diagnosed in recent 5 years). Then the most prevalent subtypes and characters of the disease are evaluated and compared to make clear if the presenting pattern and behaviour of the disease has changed in the last 2 decades.
Overall 1430 patients with IBD including 1207 patients with ulcerative colitis (UC) (84.5%) and 205 patients with Crohn's disease (CD; 14.3%) included. Mean age of participants at the first time of diagnosis with IBD was 30 years. The extra-intestinal involvement of IBD in groups A and B was more prevalent in comparison with group C. Most of those in groups A & B had academic education but in group C, the most prevalent educational status was high school or diploma (P = 0.012). In contrast to groups A and B, the relative prevalence of medium socioeconomic level in group C had decreased (65%). Relative prevalence of UC subtypes was similar among groups A and B (extensive colitis as most prevalent) but in group C, the most prevalent subtype is left side colitis (38.17%). The most prevalent subtype of CD in groups A and B was ileocolic involvement while in group C, upper GI involvement is significantly increased. The rate of food sensitivity among groups A and B was more than group C (P = 0.00001). The relative prevalence of patients with no flare has increased with a steady slope (P < 0.00001). Relative prevalence of presenting symptoms among patients with UC in group C differs and nowadays the rate abdominal pain (70.7%) and bloating (43.9%) have increased and frequency of diarrhoea (67.4%) has decreased.
In the recent 5 years, the pattern of UC presentation has changed. The rate of upper GI involvement in CD and relative prevalence of patients with no disease flare increased and the rate of extra intestinal involvement decreased.
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During a 6-month period (1/02/2022–30/07/2022), the information of patients with IBD who attended IBD outpatient clinics of 11 referral centre's in six countries was collected, and based on the first time of diagnosis with IBD, they were allocated as group A (those who were diagnosed more than 15 years ago), group B (those who were diagnosed with IBD between 5 and 15 years ago) and group C (IBD cases who diagnosed in recent 5 years). Then the most prevalent subtypes and characters of the disease are evaluated and compared to make clear if the presenting pattern and behaviour of the disease has changed in the last 2 decades.
Overall 1430 patients with IBD including 1207 patients with ulcerative colitis (UC) (84.5%) and 205 patients with Crohn's disease (CD; 14.3%) included. Mean age of participants at the first time of diagnosis with IBD was 30 years. The extra-intestinal involvement of IBD in groups A and B was more prevalent in comparison with group C. Most of those in groups A & B had academic education but in group C, the most prevalent educational status was high school or diploma (P = 0.012). In contrast to groups A and B, the relative prevalence of medium socioeconomic level in group C had decreased (65%). Relative prevalence of UC subtypes was similar among groups A and B (extensive colitis as most prevalent) but in group C, the most prevalent subtype is left side colitis (38.17%). The most prevalent subtype of CD in groups A and B was ileocolic involvement while in group C, upper GI involvement is significantly increased. The rate of food sensitivity among groups A and B was more than group C (P = 0.00001). The relative prevalence of patients with no flare has increased with a steady slope (P < 0.00001). Relative prevalence of presenting symptoms among patients with UC in group C differs and nowadays the rate abdominal pain (70.7%) and bloating (43.9%) have increased and frequency of diarrhoea (67.4%) has decreased.
In the recent 5 years, the pattern of UC presentation has changed. The rate of upper GI involvement in CD and relative prevalence of patients with no disease flare increased and the rate of extra intestinal involvement decreased.
None.</description><subject>Behavior</subject><subject>Flare</subject><subject>IBD</subject><issn>2589-5370</issn><issn>2589-5370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoVtR_IJKjl9Zskv2IB0HELyh40XPIJrM2JbupSVbpvzdlVTx5yszwvBnmQeisIIuCFNXlegHa2aFfUEJ5HtGS0z10RMtGzEtWk_0_9QydxrgmhFDCG1GRQzRjTZkTpD5C6mnonOp7lXzY4tZ_gsPGRlARMHx4NybrB2wHnFaANyomnD49NqCVgXiFFdar4Afv_JvVyuF-dMkOahfKXUyj2Z6gg065CKff7zF6vb97uX2cL58fnm5vlnPNyjrNGRM1L1lLQdStUQ1RpoKG1bw2TOeOt0QUtCO0Y1wQoaFoTcaoBkY4tC07RhfTv5vg30eISfY2anBODeDHKKloylpUrKwyyidUBx9jgE5ugu1V2MqCyJ1fuZaTX7nzKye_OXb-vWFsezC_oR-bGbieAMh3flgIMmoLgwZjA-gkjbf_b_gCHreOwA</recordid><startdate>202404</startdate><enddate>202404</enddate><creator>Alavinejad, Pezhman</creator><creator>Hashemi, Seyed Jalal</creator><creator>Behl, Nitin</creator><creator>Hormati, Ahmad</creator><creator>Elbasuny, Abubakr</creator><creator>Daryani, Naser Ebrahimi</creator><creator>Modarres, Mehdi Pezeshgi</creator><creator>Arshadzadeh, Masoud</creator><creator>Panahande, Samira</creator><creator>Hang, Dao Viet</creator><creator>Mahros, Aya Mohammed</creator><creator>Parsi, Abazar</creator><creator>Javaherizadeh, Hazhir</creator><creator>Rehman, Ata</creator><creator>Pawlak, Katarzyna M.</creator><creator>Ahmadi, Mitra</creator><creator>Ahmed, Mohammed Hussien</creator><creator>Farsi, Farnaz</creator><creator>Arefi, Mohammad</creator><creator>Quadri, Afreen</creator><creator>Tran, Quang Trung</creator><creator>Alborzi, Foroogh</creator><creator>Amin Alavi, Seyed Mohammad</creator><creator>Cheraghian, Bahman</creator><creator>Ramezani, Elmira</creator><creator>Gouda, Mohammed Fathi</creator><creator>Saadati, Babak</creator><creator>Quadri, Ahmed Alam</creator><creator>Hirani, Rahim</creator><creator>Maher, Maha</creator><creator>Ghoneem, Elsayed</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3213-6944</orcidid><orcidid>https://orcid.org/0000-0002-9304-9916</orcidid><orcidid>https://orcid.org/0000-0001-6857-6151</orcidid><orcidid>https://orcid.org/0000-0002-0166-9844</orcidid><orcidid>https://orcid.org/0000-0002-5701-5620</orcidid></search><sort><creationdate>202404</creationdate><title>Inflammatory bowel disease evolution in the past two decades: a chronological multinational study</title><author>Alavinejad, Pezhman ; Hashemi, Seyed Jalal ; Behl, Nitin ; Hormati, Ahmad ; Elbasuny, Abubakr ; Daryani, Naser Ebrahimi ; Modarres, Mehdi Pezeshgi ; Arshadzadeh, Masoud ; Panahande, Samira ; Hang, Dao Viet ; Mahros, Aya Mohammed ; Parsi, Abazar ; Javaherizadeh, Hazhir ; Rehman, Ata ; Pawlak, Katarzyna M. ; Ahmadi, Mitra ; Ahmed, Mohammed Hussien ; Farsi, Farnaz ; Arefi, Mohammad ; Quadri, Afreen ; Tran, Quang Trung ; Alborzi, Foroogh ; Amin Alavi, Seyed Mohammad ; Cheraghian, Bahman ; Ramezani, Elmira ; Gouda, Mohammed Fathi ; Saadati, Babak ; Quadri, Ahmed Alam ; Hirani, Rahim ; Maher, Maha ; Ghoneem, Elsayed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-3397453b2e97bda80ad6e83747d3c80a4b0912f02f34909ce1bdda82ce304ebb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Behavior</topic><topic>Flare</topic><topic>IBD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alavinejad, Pezhman</creatorcontrib><creatorcontrib>Hashemi, Seyed Jalal</creatorcontrib><creatorcontrib>Behl, Nitin</creatorcontrib><creatorcontrib>Hormati, Ahmad</creatorcontrib><creatorcontrib>Elbasuny, Abubakr</creatorcontrib><creatorcontrib>Daryani, Naser Ebrahimi</creatorcontrib><creatorcontrib>Modarres, Mehdi Pezeshgi</creatorcontrib><creatorcontrib>Arshadzadeh, Masoud</creatorcontrib><creatorcontrib>Panahande, Samira</creatorcontrib><creatorcontrib>Hang, Dao Viet</creatorcontrib><creatorcontrib>Mahros, Aya Mohammed</creatorcontrib><creatorcontrib>Parsi, Abazar</creatorcontrib><creatorcontrib>Javaherizadeh, Hazhir</creatorcontrib><creatorcontrib>Rehman, Ata</creatorcontrib><creatorcontrib>Pawlak, Katarzyna M.</creatorcontrib><creatorcontrib>Ahmadi, Mitra</creatorcontrib><creatorcontrib>Ahmed, Mohammed Hussien</creatorcontrib><creatorcontrib>Farsi, Farnaz</creatorcontrib><creatorcontrib>Arefi, Mohammad</creatorcontrib><creatorcontrib>Quadri, Afreen</creatorcontrib><creatorcontrib>Tran, Quang Trung</creatorcontrib><creatorcontrib>Alborzi, Foroogh</creatorcontrib><creatorcontrib>Amin Alavi, Seyed Mohammad</creatorcontrib><creatorcontrib>Cheraghian, Bahman</creatorcontrib><creatorcontrib>Ramezani, Elmira</creatorcontrib><creatorcontrib>Gouda, Mohammed Fathi</creatorcontrib><creatorcontrib>Saadati, Babak</creatorcontrib><creatorcontrib>Quadri, Ahmed Alam</creatorcontrib><creatorcontrib>Hirani, Rahim</creatorcontrib><creatorcontrib>Maher, Maha</creatorcontrib><creatorcontrib>Ghoneem, Elsayed</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>EClinicalMedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alavinejad, Pezhman</au><au>Hashemi, Seyed Jalal</au><au>Behl, Nitin</au><au>Hormati, Ahmad</au><au>Elbasuny, Abubakr</au><au>Daryani, Naser Ebrahimi</au><au>Modarres, Mehdi Pezeshgi</au><au>Arshadzadeh, Masoud</au><au>Panahande, Samira</au><au>Hang, Dao Viet</au><au>Mahros, Aya Mohammed</au><au>Parsi, Abazar</au><au>Javaherizadeh, Hazhir</au><au>Rehman, Ata</au><au>Pawlak, Katarzyna M.</au><au>Ahmadi, Mitra</au><au>Ahmed, Mohammed Hussien</au><au>Farsi, Farnaz</au><au>Arefi, Mohammad</au><au>Quadri, Afreen</au><au>Tran, Quang Trung</au><au>Alborzi, Foroogh</au><au>Amin Alavi, Seyed Mohammad</au><au>Cheraghian, Bahman</au><au>Ramezani, Elmira</au><au>Gouda, Mohammed Fathi</au><au>Saadati, Babak</au><au>Quadri, Ahmed Alam</au><au>Hirani, Rahim</au><au>Maher, Maha</au><au>Ghoneem, Elsayed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory bowel disease evolution in the past two decades: a chronological multinational study</atitle><jtitle>EClinicalMedicine</jtitle><addtitle>EClinicalMedicine</addtitle><date>2024-04</date><risdate>2024</risdate><volume>70</volume><spage>102542</spage><epage>102542</epage><pages>102542-102542</pages><artnum>102542</artnum><issn>2589-5370</issn><eissn>2589-5370</eissn><abstract>The multifactorial nature of inflammatory bowel disease (IBD), which manifests differently in individuals creates a need for a better understanding of the behaviour and pattern of the disease due to environmental factors. The current study aimed to study the changes in IBD behaviour, presentation, and characteristics in patients over the past two decades with a goal of improving patients’ diagnosis, management and outcomes.
During a 6-month period (1/02/2022–30/07/2022), the information of patients with IBD who attended IBD outpatient clinics of 11 referral centre's in six countries was collected, and based on the first time of diagnosis with IBD, they were allocated as group A (those who were diagnosed more than 15 years ago), group B (those who were diagnosed with IBD between 5 and 15 years ago) and group C (IBD cases who diagnosed in recent 5 years). Then the most prevalent subtypes and characters of the disease are evaluated and compared to make clear if the presenting pattern and behaviour of the disease has changed in the last 2 decades.
Overall 1430 patients with IBD including 1207 patients with ulcerative colitis (UC) (84.5%) and 205 patients with Crohn's disease (CD; 14.3%) included. Mean age of participants at the first time of diagnosis with IBD was 30 years. The extra-intestinal involvement of IBD in groups A and B was more prevalent in comparison with group C. Most of those in groups A & B had academic education but in group C, the most prevalent educational status was high school or diploma (P = 0.012). In contrast to groups A and B, the relative prevalence of medium socioeconomic level in group C had decreased (65%). Relative prevalence of UC subtypes was similar among groups A and B (extensive colitis as most prevalent) but in group C, the most prevalent subtype is left side colitis (38.17%). The most prevalent subtype of CD in groups A and B was ileocolic involvement while in group C, upper GI involvement is significantly increased. The rate of food sensitivity among groups A and B was more than group C (P = 0.00001). The relative prevalence of patients with no flare has increased with a steady slope (P < 0.00001). Relative prevalence of presenting symptoms among patients with UC in group C differs and nowadays the rate abdominal pain (70.7%) and bloating (43.9%) have increased and frequency of diarrhoea (67.4%) has decreased.
In the recent 5 years, the pattern of UC presentation has changed. The rate of upper GI involvement in CD and relative prevalence of patients with no disease flare increased and the rate of extra intestinal involvement decreased.
None.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38525407</pmid><doi>10.1016/j.eclinm.2024.102542</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3213-6944</orcidid><orcidid>https://orcid.org/0000-0002-9304-9916</orcidid><orcidid>https://orcid.org/0000-0001-6857-6151</orcidid><orcidid>https://orcid.org/0000-0002-0166-9844</orcidid><orcidid>https://orcid.org/0000-0002-5701-5620</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2589-5370 |
| ispartof | EClinicalMedicine, 2024-04, Vol.70, p.102542-102542, Article 102542 |
| issn | 2589-5370 2589-5370 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2985796356 |
| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Behavior Flare IBD |
| title | Inflammatory bowel disease evolution in the past two decades: a chronological multinational study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T16%3A03%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inflammatory%20bowel%20disease%20evolution%20in%20the%20past%20two%20decades:%20a%20chronological%20multinational%20study&rft.jtitle=EClinicalMedicine&rft.au=Alavinejad,%20Pezhman&rft.date=2024-04&rft.volume=70&rft.spage=102542&rft.epage=102542&rft.pages=102542-102542&rft.artnum=102542&rft.issn=2589-5370&rft.eissn=2589-5370&rft_id=info:doi/10.1016/j.eclinm.2024.102542&rft_dat=%3Cproquest_cross%3E2985796356%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2985796356&rft_id=info:pmid/38525407&rft_els_id=S2589537024001214&rfr_iscdi=true |