Investigations on the genotoxic potential of styrene in Fischer 344 rats using multiple endpoints

Genotoxicity of styrene monomer was evaluated in male Fischer 344 rats using the alkaline comet assay for DNA damage, micronucleus assay for cytogenetic damage and the Pig‐a assay for gene mutations. In a dose range finding (DRF) study, styrene was administered by oral gavage in corn oil for 28 cons...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Environmental and molecular mutagenesis 2024-01, Vol.65 (1-2), p.67-75
1. Verfasser:	Gollapudi, B. Bhaskar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adequacy aneugenicity Animal models Animals Assaying Bioassays Bioavailability Body weight Central nervous system clastogenicity comet Comet assay Comet Assay - methods Cytogenetics Damage detection DNA Damage Dosage Duodenum Erythrocytes Ethyl nitrosourea Genotoxicity In vivo In vivo methods and tests Male micronucleus Micronucleus Tests - methods Mutagenicity Tests - methods Mutation Oils & fats Oral administration Organ weight Peripheral blood Pig‐a Plasma levels Rangefinding Rats Rats, Inbred F344 Rats, Sprague-Dawley Styrene Styrene - toxicity Styrenes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!