Rheumatoid arthritis: remission without biotherapy? The experience of Burkina Faso (West Africa)
the objective of this study was to evaluate the therapeutic response of patients treated with disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis (RA). descriptive and analytical single-center cross-sectional study conducted in Burkina Faso from January 2019 to December 2021 in p...
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| Veröffentlicht in: | The Pan African medical journal 2024, Vol.47, p.12-12 |
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| creator | Ouédraogo, Aboubakar Kabore, Fulgence Zabsonré/Tiendrebéogo, Wendlasida Joëlle Stéphanie Nonguierma, Victor Savadogo, Binta Abassiri, Kantiga Aida Eudoxie Zongo, Yamyellé Enselme Damade, Richard Ouédraogo, Dieu-Donné |
| description | the objective of this study was to evaluate the therapeutic response of patients treated with disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis (RA).
descriptive and analytical single-center cross-sectional study conducted in Burkina Faso from January 2019 to December 2021 in patients with RA meeting American Rheumatism Association/European League against rheumatism criteria. Therapeutic response was assessed according to the criteria of the European League Against Rheumatism, the clinical disease activity index and the simplified disease activity Index after at least six months of treatment.
one hundred and three patients, including 85 women were included. The average age of the patients was 50.14 years ± 15.04 years. Eighty-seven patients (84.47%) were ACPA positive and 50 patients (48.54%) had radiological damage at inclusion. The mean DAS28-CRP, CDAI and SDAI were 5.17, respectively; 32.16 and 35.48 at inclusion compared to 2.53; 7.83 and 8.76 after at least six months of treatment (p |
| doi_str_mv | 10.11604/pamj.2024.47.12.37537 |
| format | Article |
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descriptive and analytical single-center cross-sectional study conducted in Burkina Faso from January 2019 to December 2021 in patients with RA meeting American Rheumatism Association/European League against rheumatism criteria. Therapeutic response was assessed according to the criteria of the European League Against Rheumatism, the clinical disease activity index and the simplified disease activity Index after at least six months of treatment.
one hundred and three patients, including 85 women were included. The average age of the patients was 50.14 years ± 15.04 years. Eighty-seven patients (84.47%) were ACPA positive and 50 patients (48.54%) had radiological damage at inclusion. The mean DAS28-CRP, CDAI and SDAI were 5.17, respectively; 32.16 and 35.48 at inclusion compared to 2.53; 7.83 and 8.76 after at least six months of treatment (p<0.0001). Ninety-six patients (93.20%) were treated with methotrexate. According to the criteria of the European League Against Rheumatism, 89 patients (86.41%) were good responders, 62 patients (60.19%) were in remission. Major improvement was observed in 53 patients (51.46%) as assessed by the Clinical Disease Activity Index and the Simplified Disease Activity Index.
despite the unavailability of biotherapies in sub-Saharan Africa, remission of RA can be obtained by optimizing treatment with DMARDs and "tight control".</description><identifier>EISSN: 1937-8688</identifier><identifier>DOI: 10.11604/pamj.2024.47.12.37537</identifier><identifier>PMID: 38524108</identifier><language>eng ; fre</language><publisher>Uganda</publisher><ispartof>The Pan African medical journal, 2024, Vol.47, p.12-12</ispartof><rights>Copyright: Aboubakar Ouédraogo et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38524108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ouédraogo, Aboubakar</creatorcontrib><creatorcontrib>Kabore, Fulgence</creatorcontrib><creatorcontrib>Zabsonré/Tiendrebéogo, Wendlasida Joëlle Stéphanie</creatorcontrib><creatorcontrib>Nonguierma, Victor</creatorcontrib><creatorcontrib>Savadogo, Binta</creatorcontrib><creatorcontrib>Abassiri, Kantiga Aida Eudoxie</creatorcontrib><creatorcontrib>Zongo, Yamyellé Enselme</creatorcontrib><creatorcontrib>Damade, Richard</creatorcontrib><creatorcontrib>Ouédraogo, Dieu-Donné</creatorcontrib><title>Rheumatoid arthritis: remission without biotherapy? The experience of Burkina Faso (West Africa)</title><title>The Pan African medical journal</title><addtitle>Pan Afr Med J</addtitle><description>the objective of this study was to evaluate the therapeutic response of patients treated with disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis (RA).
descriptive and analytical single-center cross-sectional study conducted in Burkina Faso from January 2019 to December 2021 in patients with RA meeting American Rheumatism Association/European League against rheumatism criteria. Therapeutic response was assessed according to the criteria of the European League Against Rheumatism, the clinical disease activity index and the simplified disease activity Index after at least six months of treatment.
one hundred and three patients, including 85 women were included. The average age of the patients was 50.14 years ± 15.04 years. Eighty-seven patients (84.47%) were ACPA positive and 50 patients (48.54%) had radiological damage at inclusion. The mean DAS28-CRP, CDAI and SDAI were 5.17, respectively; 32.16 and 35.48 at inclusion compared to 2.53; 7.83 and 8.76 after at least six months of treatment (p<0.0001). Ninety-six patients (93.20%) were treated with methotrexate. According to the criteria of the European League Against Rheumatism, 89 patients (86.41%) were good responders, 62 patients (60.19%) were in remission. Major improvement was observed in 53 patients (51.46%) as assessed by the Clinical Disease Activity Index and the Simplified Disease Activity Index.
despite the unavailability of biotherapies in sub-Saharan Africa, remission of RA can be obtained by optimizing treatment with DMARDs and "tight control".</description><issn>1937-8688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo1kE1LwzAYx4Mgbk6_wshxHlaTJ31JvYgOp8JAkInHmrZPaOba1CRF9-0tOE__y4__GyFzziLOUxZf96rdRcAgjuIs4hCJLBHZCZnyXGRLmUo5Iefe7xhLUynYGZkImUDMmZySj9cGh1YFa2qqXGicCcbfUIet8d7Yjn6b0Ngh0NLY0KBT_eGWbhuk-NOjM9hVSK2m94P7NJ2ia-UtXbyjD_ROO1OpqwtyqtXe4-VRZ-Rt_bBdPS03L4_Pq7vNsucxD0s5VsogkaKKhVR1DpnQoirLGkADzytZyTpPc8mYAEQtIdWJ5iqTnGmlIBYzsvjz7Z39GsYCxbigwv1edWgHX0A-BuQJCBjR-REdyhbronemVe5Q_L8ifgHZ92QI</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Ouédraogo, Aboubakar</creator><creator>Kabore, Fulgence</creator><creator>Zabsonré/Tiendrebéogo, Wendlasida Joëlle Stéphanie</creator><creator>Nonguierma, Victor</creator><creator>Savadogo, Binta</creator><creator>Abassiri, Kantiga Aida Eudoxie</creator><creator>Zongo, Yamyellé Enselme</creator><creator>Damade, Richard</creator><creator>Ouédraogo, Dieu-Donné</creator><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2024</creationdate><title>Rheumatoid arthritis: remission without biotherapy? The experience of Burkina Faso (West Africa)</title><author>Ouédraogo, Aboubakar ; Kabore, Fulgence ; Zabsonré/Tiendrebéogo, Wendlasida Joëlle Stéphanie ; Nonguierma, Victor ; Savadogo, Binta ; Abassiri, Kantiga Aida Eudoxie ; Zongo, Yamyellé Enselme ; Damade, Richard ; Ouédraogo, Dieu-Donné</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-838572583c438ad9273f3cbbd22f219c8c8d96980032eef826f5f1a7810faa243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ouédraogo, Aboubakar</creatorcontrib><creatorcontrib>Kabore, Fulgence</creatorcontrib><creatorcontrib>Zabsonré/Tiendrebéogo, Wendlasida Joëlle Stéphanie</creatorcontrib><creatorcontrib>Nonguierma, Victor</creatorcontrib><creatorcontrib>Savadogo, Binta</creatorcontrib><creatorcontrib>Abassiri, Kantiga Aida Eudoxie</creatorcontrib><creatorcontrib>Zongo, Yamyellé Enselme</creatorcontrib><creatorcontrib>Damade, Richard</creatorcontrib><creatorcontrib>Ouédraogo, Dieu-Donné</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Pan African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ouédraogo, Aboubakar</au><au>Kabore, Fulgence</au><au>Zabsonré/Tiendrebéogo, Wendlasida Joëlle Stéphanie</au><au>Nonguierma, Victor</au><au>Savadogo, Binta</au><au>Abassiri, Kantiga Aida Eudoxie</au><au>Zongo, Yamyellé Enselme</au><au>Damade, Richard</au><au>Ouédraogo, Dieu-Donné</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rheumatoid arthritis: remission without biotherapy? The experience of Burkina Faso (West Africa)</atitle><jtitle>The Pan African medical journal</jtitle><addtitle>Pan Afr Med J</addtitle><date>2024</date><risdate>2024</risdate><volume>47</volume><spage>12</spage><epage>12</epage><pages>12-12</pages><eissn>1937-8688</eissn><abstract>the objective of this study was to evaluate the therapeutic response of patients treated with disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis (RA).
descriptive and analytical single-center cross-sectional study conducted in Burkina Faso from January 2019 to December 2021 in patients with RA meeting American Rheumatism Association/European League against rheumatism criteria. Therapeutic response was assessed according to the criteria of the European League Against Rheumatism, the clinical disease activity index and the simplified disease activity Index after at least six months of treatment.
one hundred and three patients, including 85 women were included. The average age of the patients was 50.14 years ± 15.04 years. Eighty-seven patients (84.47%) were ACPA positive and 50 patients (48.54%) had radiological damage at inclusion. The mean DAS28-CRP, CDAI and SDAI were 5.17, respectively; 32.16 and 35.48 at inclusion compared to 2.53; 7.83 and 8.76 after at least six months of treatment (p<0.0001). Ninety-six patients (93.20%) were treated with methotrexate. According to the criteria of the European League Against Rheumatism, 89 patients (86.41%) were good responders, 62 patients (60.19%) were in remission. Major improvement was observed in 53 patients (51.46%) as assessed by the Clinical Disease Activity Index and the Simplified Disease Activity Index.
despite the unavailability of biotherapies in sub-Saharan Africa, remission of RA can be obtained by optimizing treatment with DMARDs and "tight control".</abstract><cop>Uganda</cop><pmid>38524108</pmid><doi>10.11604/pamj.2024.47.12.37537</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | African Journals Online (Open Access); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| title | Rheumatoid arthritis: remission without biotherapy? The experience of Burkina Faso (West Africa) |
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