Phage resistance in Klebsiella pneumoniae and bidirectional effects impacting antibiotic susceptibility

Bacteriophage (phage) therapy is a promising anti-infective option to combat antimicrobial resistance. However, the clinical utilization of phage therapy has been severely compromised by the potential emergence of phage resistance. Although certain phage resistance mechanisms can restore bacterial s...

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Veröffentlicht in:	Clinical microbiology and infection 2024-06, Vol.30 (6), p.787-794
Hauptverfasser:	Nang, Sue C., Lu, Jing, Yu, Heidi H., Wickremasinghe, Hasini, Azad, Mohammad A.K., Han, Meiling, Zhao, Jinxin, Rao, Gauri, Bergen, Phillip J., Velkov, Tony, Sherry, Norelle, McCarthy, David T., Aslam, Saima, Schooley, Robert T., Howden, Benjamin P., Barr, Jeremy J., Zhu, Yan, Li, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotic Antimicrobial resistance Bacteriophage therapy Bacteriophages - genetics DNA Transposable Elements Drug Resistance, Bacterial Humans Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - virology Microbial Sensitivity Tests Mutation Phage resistance Phage steering Phage Therapy
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