Diagnostic value of vietnamese smell identification test in Parkinson's disease
The Vietnamese Smell Identification Test (VSIT) has been validated in determining olfactory dysfunction in the Vietnamese population; however, its value in diagnosing Parkinson's disease (PD) has not been established. This case-control study was conducted at University Medical Center HCMC, Ho C...
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| Veröffentlicht in: | Journal of the neurological sciences 2024-04, Vol.459, p.122958-122958, Article 122958 |
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| container_title | Journal of the neurological sciences |
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| creator | Dang, Thuong Huyen Thi Tran, Tai Ngoc Xing, Frank Ha, Uyen Le Ngoc Vo, Khang Chung Ngoc Nguyen, Thanh Vinh Nguyen, Khang Vinh Le, Hien Thi Truong, Daniel |
| description | The Vietnamese Smell Identification Test (VSIT) has been validated in determining olfactory dysfunction in the Vietnamese population; however, its value in diagnosing Parkinson's disease (PD) has not been established.
This case-control study was conducted at University Medical Center HCMC, Ho Chi Minh City, Vietnam. The study sample included non-demented PD patients and healthy controls (HC) who were gender- and age-matched. All participants were evaluated for odor identification ability using the VSIT and the Brief Smell Identification Test (BSIT).
A total of 218 HCs and 218 PD patients participated in the study. The median VSIT and BSIT scores were significantly different between PD and HC groups (VSIT, 5 (3) vs. 9 (2), P |
| doi_str_mv | 10.1016/j.jns.2024.122958 |
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This case-control study was conducted at University Medical Center HCMC, Ho Chi Minh City, Vietnam. The study sample included non-demented PD patients and healthy controls (HC) who were gender- and age-matched. All participants were evaluated for odor identification ability using the VSIT and the Brief Smell Identification Test (BSIT).
A total of 218 HCs and 218 PD patients participated in the study. The median VSIT and BSIT scores were significantly different between PD and HC groups (VSIT, 5 (3) vs. 9 (2), P < 0.0001; BSIT, 6 (3) vs 8 (2), P < 0.0001). Using the cut-off of <8 for correct answers out of 12 odorants, the VSIT had higher sensitivity (84.4%) and specificity (86.2%) than those of the BSIT (sensitivity of 81.7% and specificity of 69.3%) for the diagnosis of PD. The area under the curve (AUC) value was greater for the VSIT than for the BSIT (0.909 vs 0.818). The smell identification scores were not significantly correlated with disease duration, disease severity, or LEDD (all p > 0.05).
The VSIT can be a valuable ancillary tool for supporting the diagnosis of PD in Vietnam. Olfactory dysfunction in PD was unrelated to the disease duration and severity. The VSIT can be applied to improve the accuracy of clinical PD diagnosis.
•Hyposmia is an important symptom of Parkinson's disease (PD).•The ability to identify odors is influenced by culture.•The Vietnamese Smell Identification (VSIT) test has been developed and validated.•In this study, people with PD scored lower on the VSIT than healthy controls.•The VSIT may assist in the diagnosis of PD in the Vietnamese population.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2024.122958</identifier><identifier>PMID: 38522243</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Case-Control Studies ; Humans ; Odorants ; Olfaction Disorders - diagnosis ; Olfaction Disorders - etiology ; Olfactory dysfunction ; Parkinson Disease - complications ; Parkinson Disease - diagnosis ; Parkinson's disease ; Smell ; Vietnam ; Vietnamese smell identification test</subject><ispartof>Journal of the neurological sciences, 2024-04, Vol.459, p.122958-122958, Article 122958</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c348t-75c0eb3e68d414953c46fc7c63d870d46d865958f8e2056a351f6c24584deadf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2024.122958$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38522243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dang, Thuong Huyen Thi</creatorcontrib><creatorcontrib>Tran, Tai Ngoc</creatorcontrib><creatorcontrib>Xing, Frank</creatorcontrib><creatorcontrib>Ha, Uyen Le Ngoc</creatorcontrib><creatorcontrib>Vo, Khang Chung Ngoc</creatorcontrib><creatorcontrib>Nguyen, Thanh Vinh</creatorcontrib><creatorcontrib>Nguyen, Khang Vinh</creatorcontrib><creatorcontrib>Le, Hien Thi</creatorcontrib><creatorcontrib>Truong, Daniel</creatorcontrib><title>Diagnostic value of vietnamese smell identification test in Parkinson's disease</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>The Vietnamese Smell Identification Test (VSIT) has been validated in determining olfactory dysfunction in the Vietnamese population; however, its value in diagnosing Parkinson's disease (PD) has not been established.
This case-control study was conducted at University Medical Center HCMC, Ho Chi Minh City, Vietnam. The study sample included non-demented PD patients and healthy controls (HC) who were gender- and age-matched. All participants were evaluated for odor identification ability using the VSIT and the Brief Smell Identification Test (BSIT).
A total of 218 HCs and 218 PD patients participated in the study. The median VSIT and BSIT scores were significantly different between PD and HC groups (VSIT, 5 (3) vs. 9 (2), P < 0.0001; BSIT, 6 (3) vs 8 (2), P < 0.0001). Using the cut-off of <8 for correct answers out of 12 odorants, the VSIT had higher sensitivity (84.4%) and specificity (86.2%) than those of the BSIT (sensitivity of 81.7% and specificity of 69.3%) for the diagnosis of PD. The area under the curve (AUC) value was greater for the VSIT than for the BSIT (0.909 vs 0.818). The smell identification scores were not significantly correlated with disease duration, disease severity, or LEDD (all p > 0.05).
The VSIT can be a valuable ancillary tool for supporting the diagnosis of PD in Vietnam. Olfactory dysfunction in PD was unrelated to the disease duration and severity. The VSIT can be applied to improve the accuracy of clinical PD diagnosis.
•Hyposmia is an important symptom of Parkinson's disease (PD).•The ability to identify odors is influenced by culture.•The Vietnamese Smell Identification (VSIT) test has been developed and validated.•In this study, people with PD scored lower on the VSIT than healthy controls.•The VSIT may assist in the diagnosis of PD in the Vietnamese population.</description><subject>Case-Control Studies</subject><subject>Humans</subject><subject>Odorants</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Olfaction Disorders - etiology</subject><subject>Olfactory dysfunction</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson's disease</subject><subject>Smell</subject><subject>Vietnam</subject><subject>Vietnamese smell identification test</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAYhC0EglL4ASzIGywp_o4jJlQ-pUowgMRmGfsNcmmckjdF4t-TqoWR6Za7091DyAlnE864uZhP5hknggk14UJU2u6QEbelLbS1cpeMGBOi0Jy9HpBDxDljzFhb7ZMDabUQQskRebxO_j232KdAv_xiBbSt6VeCPvsGECg2sFjQFCH3qU7B96nNtAfsacr0yXcfKWObz5DGhOARjshe7RcIx1sdk5fbm-fpfTF7vHuYXs2KIJXti1IHBm8SjI2Kq0rLoEwdymBktCWLykRr9HCotiCYNl5qXpsglLYqgo-1HJPzTe-yaz9Xwx7XJAzDVp-hXaETldVlJdcgxoRvrKFrETuo3bJLje--HWduzdHN3cDRrTm6Dcchc7qtX701EP8Sv-AGw-XGAMPJgVfnMCTIAWLqIPQutumf-h_KD4NW</recordid><startdate>20240415</startdate><enddate>20240415</enddate><creator>Dang, Thuong Huyen Thi</creator><creator>Tran, Tai Ngoc</creator><creator>Xing, Frank</creator><creator>Ha, Uyen Le Ngoc</creator><creator>Vo, Khang Chung Ngoc</creator><creator>Nguyen, Thanh Vinh</creator><creator>Nguyen, Khang Vinh</creator><creator>Le, Hien Thi</creator><creator>Truong, Daniel</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240415</creationdate><title>Diagnostic value of vietnamese smell identification test in Parkinson's disease</title><author>Dang, Thuong Huyen Thi ; Tran, Tai Ngoc ; Xing, Frank ; Ha, Uyen Le Ngoc ; Vo, Khang Chung Ngoc ; Nguyen, Thanh Vinh ; Nguyen, Khang Vinh ; Le, Hien Thi ; Truong, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-75c0eb3e68d414953c46fc7c63d870d46d865958f8e2056a351f6c24584deadf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Case-Control Studies</topic><topic>Humans</topic><topic>Odorants</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Olfaction Disorders - etiology</topic><topic>Olfactory dysfunction</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson's disease</topic><topic>Smell</topic><topic>Vietnam</topic><topic>Vietnamese smell identification test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dang, Thuong Huyen Thi</creatorcontrib><creatorcontrib>Tran, Tai Ngoc</creatorcontrib><creatorcontrib>Xing, Frank</creatorcontrib><creatorcontrib>Ha, Uyen Le Ngoc</creatorcontrib><creatorcontrib>Vo, Khang Chung Ngoc</creatorcontrib><creatorcontrib>Nguyen, Thanh Vinh</creatorcontrib><creatorcontrib>Nguyen, Khang Vinh</creatorcontrib><creatorcontrib>Le, Hien Thi</creatorcontrib><creatorcontrib>Truong, Daniel</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dang, Thuong Huyen Thi</au><au>Tran, Tai Ngoc</au><au>Xing, Frank</au><au>Ha, Uyen Le Ngoc</au><au>Vo, Khang Chung Ngoc</au><au>Nguyen, Thanh Vinh</au><au>Nguyen, Khang Vinh</au><au>Le, Hien Thi</au><au>Truong, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of vietnamese smell identification test in Parkinson's disease</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2024-04-15</date><risdate>2024</risdate><volume>459</volume><spage>122958</spage><epage>122958</epage><pages>122958-122958</pages><artnum>122958</artnum><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>The Vietnamese Smell Identification Test (VSIT) has been validated in determining olfactory dysfunction in the Vietnamese population; however, its value in diagnosing Parkinson's disease (PD) has not been established.
This case-control study was conducted at University Medical Center HCMC, Ho Chi Minh City, Vietnam. The study sample included non-demented PD patients and healthy controls (HC) who were gender- and age-matched. All participants were evaluated for odor identification ability using the VSIT and the Brief Smell Identification Test (BSIT).
A total of 218 HCs and 218 PD patients participated in the study. The median VSIT and BSIT scores were significantly different between PD and HC groups (VSIT, 5 (3) vs. 9 (2), P < 0.0001; BSIT, 6 (3) vs 8 (2), P < 0.0001). Using the cut-off of <8 for correct answers out of 12 odorants, the VSIT had higher sensitivity (84.4%) and specificity (86.2%) than those of the BSIT (sensitivity of 81.7% and specificity of 69.3%) for the diagnosis of PD. The area under the curve (AUC) value was greater for the VSIT than for the BSIT (0.909 vs 0.818). The smell identification scores were not significantly correlated with disease duration, disease severity, or LEDD (all p > 0.05).
The VSIT can be a valuable ancillary tool for supporting the diagnosis of PD in Vietnam. Olfactory dysfunction in PD was unrelated to the disease duration and severity. The VSIT can be applied to improve the accuracy of clinical PD diagnosis.
•Hyposmia is an important symptom of Parkinson's disease (PD).•The ability to identify odors is influenced by culture.•The Vietnamese Smell Identification (VSIT) test has been developed and validated.•In this study, people with PD scored lower on the VSIT than healthy controls.•The VSIT may assist in the diagnosis of PD in the Vietnamese population.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38522243</pmid><doi>10.1016/j.jns.2024.122958</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Case-Control Studies Humans Odorants Olfaction Disorders - diagnosis Olfaction Disorders - etiology Olfactory dysfunction Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson's disease Smell Vietnam Vietnamese smell identification test |
| title | Diagnostic value of vietnamese smell identification test in Parkinson's disease |
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