Exposure to omethoate during stapling of ornamental plants in intensive cultivation tunnels: influence of environmental conditions on absorption of the pesticide
This report describes a study of exposure to omethoate during manual operations with ornamental plants in two intensive cultivation tunnels (tunnel 8 and tunnel 5). Airborne concentrations of omethoate were in the range 1.48-5.36 nmol/m(3). Total skin contamination in the range 329.94-12,934.46 nmol...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 2005-11, Vol.49 (4), p.577-588 |
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| creator | Aprea, C Centi, L Santini, S Lunghini, L Banchi, B Sciarra, G |
| description | This report describes a study of exposure to omethoate during manual operations with ornamental plants in two intensive cultivation tunnels (tunnel 8 and tunnel 5). Airborne concentrations of omethoate were in the range 1.48-5.36 nmol/m(3). Total skin contamination in the range 329.94-12,934.46 nmol/day averaged 98.1 +/- 1.1% and 99.3 +/- 0.6% of the total potential dose in tunnel 8 and tunnel 5, respectively. Estimated absorbed doses during work in tunnel 5 were much higher than the acceptable daily intake of omethoate, which is 1.41 nmol/kg b.w. This finding shows that organization of the work or the protective clothing worn in tunnel 5 did not protect the workers from exposure. Urinary excretion of alkylphosphates was significantly higher than in the general population, increasing with exposure and usually showing a peak in the urine sample collected after the work shift. Urinary alkylphosphates showed a good correlation with estimated potential doses during work in tunnel 8 and are confirmed as sensitive biological indicators of exposure to phosphoric esters. The linear regression analysis between the urinary excretion of alkylphosphate, expressed as total nmol excreted in 24 h, and total cutaneous dose allows for estimating that the fraction of omethoate absorbed through the skin during work in tunnel 8 is about 16.5%. |
| doi_str_mv | 10.1007/s00244-005-8025-2 |
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Airborne concentrations of omethoate were in the range 1.48-5.36 nmol/m(3). Total skin contamination in the range 329.94-12,934.46 nmol/day averaged 98.1 +/- 1.1% and 99.3 +/- 0.6% of the total potential dose in tunnel 8 and tunnel 5, respectively. Estimated absorbed doses during work in tunnel 5 were much higher than the acceptable daily intake of omethoate, which is 1.41 nmol/kg b.w. This finding shows that organization of the work or the protective clothing worn in tunnel 5 did not protect the workers from exposure. Urinary excretion of alkylphosphates was significantly higher than in the general population, increasing with exposure and usually showing a peak in the urine sample collected after the work shift. Urinary alkylphosphates showed a good correlation with estimated potential doses during work in tunnel 8 and are confirmed as sensitive biological indicators of exposure to phosphoric esters. The linear regression analysis between the urinary excretion of alkylphosphate, expressed as total nmol excreted in 24 h, and total cutaneous dose allows for estimating that the fraction of omethoate absorbed through the skin during work in tunnel 8 is about 16.5%.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/s00244-005-8025-2</identifier><identifier>PMID: 16132410</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>Heidelberg: Springer-Verlag</publisher><subject>absorption ; Adult ; Agriculture ; Animal, plant and microbial ecology ; Applied ecology ; Biological and medical sciences ; dermal exposure ; Dimethoate - analogs & derivatives ; Dimethoate - pharmacokinetics ; Dimethoate - urine ; Ecotoxicology, biological effects of pollution ; excretion ; Female ; Fundamental and applied biological sciences. Psychology ; Gas Chromatography-Mass Spectrometry ; General aspects ; human health ; Humans ; inhalation exposure ; Inhalation Exposure - analysis ; insecticide residues ; Insecticides - pharmacokinetics ; Insecticides - urine ; Middle Aged ; occupational exposure ; Occupational Exposure - analysis ; omethoate ; ornamental plants ; Pesticide Residues - analysis ; phosphates ; Phosphates - urine ; Plants - chemistry ; Protective Clothing ; Skin Absorption - physiology ; toxicity</subject><ispartof>Archives of environmental contamination and toxicology, 2005-11, Vol.49 (4), p.577-588</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17361889$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16132410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aprea, C</creatorcontrib><creatorcontrib>Centi, L</creatorcontrib><creatorcontrib>Santini, S</creatorcontrib><creatorcontrib>Lunghini, L</creatorcontrib><creatorcontrib>Banchi, B</creatorcontrib><creatorcontrib>Sciarra, G</creatorcontrib><title>Exposure to omethoate during stapling of ornamental plants in intensive cultivation tunnels: influence of environmental conditions on absorption of the pesticide</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><description>This report describes a study of exposure to omethoate during manual operations with ornamental plants in two intensive cultivation tunnels (tunnel 8 and tunnel 5). Airborne concentrations of omethoate were in the range 1.48-5.36 nmol/m(3). Total skin contamination in the range 329.94-12,934.46 nmol/day averaged 98.1 +/- 1.1% and 99.3 +/- 0.6% of the total potential dose in tunnel 8 and tunnel 5, respectively. Estimated absorbed doses during work in tunnel 5 were much higher than the acceptable daily intake of omethoate, which is 1.41 nmol/kg b.w. This finding shows that organization of the work or the protective clothing worn in tunnel 5 did not protect the workers from exposure. Urinary excretion of alkylphosphates was significantly higher than in the general population, increasing with exposure and usually showing a peak in the urine sample collected after the work shift. Urinary alkylphosphates showed a good correlation with estimated potential doses during work in tunnel 8 and are confirmed as sensitive biological indicators of exposure to phosphoric esters. The linear regression analysis between the urinary excretion of alkylphosphate, expressed as total nmol excreted in 24 h, and total cutaneous dose allows for estimating that the fraction of omethoate absorbed through the skin during work in tunnel 8 is about 16.5%.</description><subject>absorption</subject><subject>Adult</subject><subject>Agriculture</subject><subject>Animal, plant and microbial ecology</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>dermal exposure</subject><subject>Dimethoate - analogs & derivatives</subject><subject>Dimethoate - pharmacokinetics</subject><subject>Dimethoate - urine</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>excretion</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General aspects</subject><subject>human health</subject><subject>Humans</subject><subject>inhalation exposure</subject><subject>Inhalation Exposure - analysis</subject><subject>insecticide residues</subject><subject>Insecticides - pharmacokinetics</subject><subject>Insecticides - urine</subject><subject>Middle Aged</subject><subject>occupational exposure</subject><subject>Occupational Exposure - analysis</subject><subject>omethoate</subject><subject>ornamental plants</subject><subject>Pesticide Residues - analysis</subject><subject>phosphates</subject><subject>Phosphates - urine</subject><subject>Plants - chemistry</subject><subject>Protective Clothing</subject><subject>Skin Absorption - physiology</subject><subject>toxicity</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctu1TAQBuAIgehp4QHYgDd0Fxhf4tjsqqpcpEosoOvIicetUWIH2zmCx-FN8WkPYlnJki35m380mqZ5ReEdBejfZwAmRAvQtQpY17InzY4KzlrogT9tdgAaWsEFPWlOc_4BQJlS4nlzQiXlTFDYNX-ufq0xbwlJiSQuWO6iKUjslny4JbmYdT48oiMxBbNgKGYm62xCycSHegqG7PdIpm0ufm-Kj4GULQSc84f67eYNw4SHAAx7n2I4ZkwxWH_QmdQKM-aY1vviKssdkhVz8ZO3-KJ55syc8eXxPmtuPl59v_zcXn_99OXy4rp1vJOlZXxUk-0ljKy3FJlFJztQ2mrogIHujVBaTUpKKylobrWW2tkRneOgqORnzflD7priz612HxafJ5zrrBi3PDCtqJACHodKU9Yr_Sikuu5G9qzC10e4jQvaYU1-Men38G9NFbw9ApMnM7tkwuTzf9dzSdV9xzcPzpk4mNtUzc03BpQDBamZAv4XSu2uYQ</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Aprea, C</creator><creator>Centi, L</creator><creator>Santini, S</creator><creator>Lunghini, L</creator><creator>Banchi, B</creator><creator>Sciarra, G</creator><general>Springer-Verlag</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QH</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope><scope>7TB</scope></search><sort><creationdate>20051101</creationdate><title>Exposure to omethoate during stapling of ornamental plants in intensive cultivation tunnels: influence of environmental conditions on absorption of the pesticide</title><author>Aprea, C ; Centi, L ; Santini, S ; Lunghini, L ; Banchi, B ; Sciarra, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f356t-23b8cd760b27d1e2def65089d90502097a4898c866d61093d9969fdbeff308163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>absorption</topic><topic>Adult</topic><topic>Agriculture</topic><topic>Animal, plant and microbial ecology</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>dermal exposure</topic><topic>Dimethoate - analogs & derivatives</topic><topic>Dimethoate - pharmacokinetics</topic><topic>Dimethoate - urine</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>excretion</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General aspects</topic><topic>human health</topic><topic>Humans</topic><topic>inhalation exposure</topic><topic>Inhalation Exposure - analysis</topic><topic>insecticide residues</topic><topic>Insecticides - pharmacokinetics</topic><topic>Insecticides - urine</topic><topic>Middle Aged</topic><topic>occupational exposure</topic><topic>Occupational Exposure - analysis</topic><topic>omethoate</topic><topic>ornamental plants</topic><topic>Pesticide Residues - analysis</topic><topic>phosphates</topic><topic>Phosphates - urine</topic><topic>Plants - chemistry</topic><topic>Protective Clothing</topic><topic>Skin Absorption - physiology</topic><topic>toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aprea, C</creatorcontrib><creatorcontrib>Centi, L</creatorcontrib><creatorcontrib>Santini, S</creatorcontrib><creatorcontrib>Lunghini, L</creatorcontrib><creatorcontrib>Banchi, B</creatorcontrib><creatorcontrib>Sciarra, G</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Aqualine</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><jtitle>Archives of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aprea, C</au><au>Centi, L</au><au>Santini, S</au><au>Lunghini, L</au><au>Banchi, B</au><au>Sciarra, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to omethoate during stapling of ornamental plants in intensive cultivation tunnels: influence of environmental conditions on absorption of the pesticide</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>49</volume><issue>4</issue><spage>577</spage><epage>588</epage><pages>577-588</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>This report describes a study of exposure to omethoate during manual operations with ornamental plants in two intensive cultivation tunnels (tunnel 8 and tunnel 5). Airborne concentrations of omethoate were in the range 1.48-5.36 nmol/m(3). Total skin contamination in the range 329.94-12,934.46 nmol/day averaged 98.1 +/- 1.1% and 99.3 +/- 0.6% of the total potential dose in tunnel 8 and tunnel 5, respectively. Estimated absorbed doses during work in tunnel 5 were much higher than the acceptable daily intake of omethoate, which is 1.41 nmol/kg b.w. This finding shows that organization of the work or the protective clothing worn in tunnel 5 did not protect the workers from exposure. Urinary excretion of alkylphosphates was significantly higher than in the general population, increasing with exposure and usually showing a peak in the urine sample collected after the work shift. Urinary alkylphosphates showed a good correlation with estimated potential doses during work in tunnel 8 and are confirmed as sensitive biological indicators of exposure to phosphoric esters. 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| subjects | absorption Adult Agriculture Animal, plant and microbial ecology Applied ecology Biological and medical sciences dermal exposure Dimethoate - analogs & derivatives Dimethoate - pharmacokinetics Dimethoate - urine Ecotoxicology, biological effects of pollution excretion Female Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry General aspects human health Humans inhalation exposure Inhalation Exposure - analysis insecticide residues Insecticides - pharmacokinetics Insecticides - urine Middle Aged occupational exposure Occupational Exposure - analysis omethoate ornamental plants Pesticide Residues - analysis phosphates Phosphates - urine Plants - chemistry Protective Clothing Skin Absorption - physiology toxicity |
| title | Exposure to omethoate during stapling of ornamental plants in intensive cultivation tunnels: influence of environmental conditions on absorption of the pesticide |
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