Pollution prevention and waste treatment in chemical synthesis processes for pharmaceutical industry
Chemical synthesis processes of the pharmaceuticals industry produce wastewaters which are variable in character and highly strong. In-plant controls are important and highly effective in determining the final wastewater quality. At any rate several stages of treatment comprised of physical, chemica...
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| Veröffentlicht in: | Water science and technology 1999, Vol.39 (10-11), p.265-271 |
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| creator | Kabdasli, I Guerel, M Tuenay, O |
| description | Chemical synthesis processes of the pharmaceuticals industry produce wastewaters which are variable in character and highly strong. In-plant controls are important and highly effective in determining the final wastewater quality. At any rate several stages of treatment comprised of physical, chemical and biological are required to obtain a reasonable degree of treatment. The problem is further complicated in small-scale plants due to low volume of wastewaters and dilution requirements. In this study, a small-scale pharmaceuticals plant producing three common active materials was experimentally evaluated to assess the waste management alternatives. The processes were evaluated and a source-based pollution profile was prepared. Paracetamol wastewaters were found to be readily biodegradable. Omeprazole wastewaters could be biologically treated only after significant chemical treatment. Mephenoxalone wastewaters were in no case biologically degradable. Paracetamol and pretreated Omeprazole wastewaters could be biologically treated down to several hundreds of ppm COD at as high as 0.5 g COD/g VSS day F/M ratio after several fold dilution. Results of the study were evaluated and discussed. |
| doi_str_mv | 10.1016/S0273-1223(99)00287-5 |
| format | Article |
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In-plant controls are important and highly effective in determining the final wastewater quality. At any rate several stages of treatment comprised of physical, chemical and biological are required to obtain a reasonable degree of treatment. The problem is further complicated in small-scale plants due to low volume of wastewaters and dilution requirements. In this study, a small-scale pharmaceuticals plant producing three common active materials was experimentally evaluated to assess the waste management alternatives. The processes were evaluated and a source-based pollution profile was prepared. Paracetamol wastewaters were found to be readily biodegradable. Omeprazole wastewaters could be biologically treated only after significant chemical treatment. Mephenoxalone wastewaters were in no case biologically degradable. Paracetamol and pretreated Omeprazole wastewaters could be biologically treated down to several hundreds of ppm COD at as high as 0.5 g COD/g VSS day F/M ratio after several fold dilution. Results of the study were evaluated and discussed.</description><identifier>ISSN: 0273-1223</identifier><identifier>ISBN: 0080428185</identifier><identifier>ISBN: 9780080428185</identifier><identifier>EISSN: 1996-9732</identifier><identifier>DOI: 10.1016/S0273-1223(99)00287-5</identifier><identifier>CODEN: WSTED4</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Analgesics ; Applied sciences ; Biodegradability ; Biodegradation ; Biological and medical sciences ; Biological treatability ; Biological treatment of waters ; Biological water treatment ; Biotechnology ; chemical oxidation ; Chemical oxygen demand ; Chemical synthesis ; chemical synthesis wastewaters ; Chemical treatment ; Chemical water treatment ; Dilution ; Drug products plants ; Drugs ; Environment and pollution ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; Industrial applications and implications. Economical aspects ; Industrial wastewaters ; mephenoxalone ; Mephenoxalone wastewaters ; Omeprazole ; Omeprazole wastewaters ; Oxidation ; Paracetamol ; Paracetamol wastewaters ; Pharmaceutical industry ; Pharmaceuticals ; pharmaceuticals industry ; Plants (botany) ; Pollution ; Pollution abatement ; Pollution prevention ; Waste management ; Waste treatment ; Wastewater ; Wastewater treatment ; Wastewaters ; Water pollution control ; Water treatment and pollution</subject><ispartof>Water science and technology, 1999, Vol.39 (10-11), p.265-271</ispartof><rights>1999 International Association on Water Quality</rights><rights>1999 INIST-CNRS</rights><rights>Copyright IWA Publishing May 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-4489835efcc29e71173aee7b0773916701d205d70d204db3cd4e2b8f9f1e59c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4010,4036,4037,23911,23912,25120,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1824425$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><contributor>Nyholm, N (eds)</contributor><contributor>Englande, AJ Jr</contributor><creatorcontrib>Kabdasli, I</creatorcontrib><creatorcontrib>Guerel, M</creatorcontrib><creatorcontrib>Tuenay, O</creatorcontrib><title>Pollution prevention and waste treatment in chemical synthesis processes for pharmaceutical industry</title><title>Water science and technology</title><description>Chemical synthesis processes of the pharmaceuticals industry produce wastewaters which are variable in character and highly strong. In-plant controls are important and highly effective in determining the final wastewater quality. At any rate several stages of treatment comprised of physical, chemical and biological are required to obtain a reasonable degree of treatment. The problem is further complicated in small-scale plants due to low volume of wastewaters and dilution requirements. In this study, a small-scale pharmaceuticals plant producing three common active materials was experimentally evaluated to assess the waste management alternatives. The processes were evaluated and a source-based pollution profile was prepared. Paracetamol wastewaters were found to be readily biodegradable. Omeprazole wastewaters could be biologically treated only after significant chemical treatment. Mephenoxalone wastewaters were in no case biologically degradable. Paracetamol and pretreated Omeprazole wastewaters could be biologically treated down to several hundreds of ppm COD at as high as 0.5 g COD/g VSS day F/M ratio after several fold dilution. Results of the study were evaluated and discussed.</description><subject>Analgesics</subject><subject>Applied sciences</subject><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>Biological and medical sciences</subject><subject>Biological treatability</subject><subject>Biological treatment of waters</subject><subject>Biological water treatment</subject><subject>Biotechnology</subject><subject>chemical oxidation</subject><subject>Chemical oxygen demand</subject><subject>Chemical synthesis</subject><subject>chemical synthesis wastewaters</subject><subject>Chemical treatment</subject><subject>Chemical water treatment</subject><subject>Dilution</subject><subject>Drug products plants</subject><subject>Drugs</subject><subject>Environment and pollution</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Industrial wastewaters</subject><subject>mephenoxalone</subject><subject>Mephenoxalone wastewaters</subject><subject>Omeprazole</subject><subject>Omeprazole wastewaters</subject><subject>Oxidation</subject><subject>Paracetamol</subject><subject>Paracetamol wastewaters</subject><subject>Pharmaceutical industry</subject><subject>Pharmaceuticals</subject><subject>pharmaceuticals industry</subject><subject>Plants (botany)</subject><subject>Pollution</subject><subject>Pollution abatement</subject><subject>Pollution prevention</subject><subject>Waste management</subject><subject>Waste treatment</subject><subject>Wastewater</subject><subject>Wastewater treatment</subject><subject>Wastewaters</subject><subject>Water pollution control</subject><subject>Water treatment and pollution</subject><issn>0273-1223</issn><issn>1996-9732</issn><isbn>0080428185</isbn><isbn>9780080428185</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqNkluLFDEQhYMXcHb1JwgNiqwPrZVbJ3laZHFVWFBQn0MmXc1k6UmPqe6V-fd2zywKvsw-VQhfnVTlHMZecnjHgTfvv4MwsuZCyAvn3gIIa2r9iK24c03tjBSP2RmABSUst_oJW_3ln7EzolsAMFLBirXfhr6fxjTkalfwDvPhGHJb_Q40YjUWDON2vq5SruIGtymGvqJ9HjdIieamISIRUtUNpdptQtmGiLPggqXcTjSW_XP2tAs94Yv7es5-Xn_8cfW5vvn66cvVh5s6KtmMtVLWWamxi1E4NJwbGRDNGoyRjjcGeCtAtwbmotq1jK1Csbad6zhqF6U8Z2-OuvNUvyak0W8TRez7kHGYyAtnjDMaHgAqq7TVp0GuhGncaUW-UE0jHgBK22i-KL76D7wdppLn__Pcqdk8B2pZWR-pWAaigp3flbQNZe85-CUq_hAVv1jvnfOHqPhlsdf36oFmq7oSckz0r9kKpcSCXR4xnG27S1g8xYQ5YpsKxtG3Qzrx0B-j6dAw</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Kabdasli, I</creator><creator>Guerel, M</creator><creator>Tuenay, O</creator><general>Elsevier Ltd</general><general>Pergamon Press</general><general>IWA Publishing</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H96</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7TV</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>1999</creationdate><title>Pollution prevention and waste treatment in chemical synthesis processes for pharmaceutical industry</title><author>Kabdasli, I ; Guerel, M ; Tuenay, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-4489835efcc29e71173aee7b0773916701d205d70d204db3cd4e2b8f9f1e59c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Analgesics</topic><topic>Applied sciences</topic><topic>Biodegradability</topic><topic>Biodegradation</topic><topic>Biological and medical sciences</topic><topic>Biological treatability</topic><topic>Biological treatment of waters</topic><topic>Biological water treatment</topic><topic>Biotechnology</topic><topic>chemical oxidation</topic><topic>Chemical oxygen demand</topic><topic>Chemical synthesis</topic><topic>chemical synthesis wastewaters</topic><topic>Chemical treatment</topic><topic>Chemical water treatment</topic><topic>Dilution</topic><topic>Drug products plants</topic><topic>Drugs</topic><topic>Environment and pollution</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Industrial wastewaters</topic><topic>mephenoxalone</topic><topic>Mephenoxalone wastewaters</topic><topic>Omeprazole</topic><topic>Omeprazole wastewaters</topic><topic>Oxidation</topic><topic>Paracetamol</topic><topic>Paracetamol wastewaters</topic><topic>Pharmaceutical industry</topic><topic>Pharmaceuticals</topic><topic>pharmaceuticals industry</topic><topic>Plants (botany)</topic><topic>Pollution</topic><topic>Pollution abatement</topic><topic>Pollution prevention</topic><topic>Waste management</topic><topic>Waste treatment</topic><topic>Wastewater</topic><topic>Wastewater treatment</topic><topic>Wastewaters</topic><topic>Water pollution control</topic><topic>Water treatment and pollution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kabdasli, I</creatorcontrib><creatorcontrib>Guerel, M</creatorcontrib><creatorcontrib>Tuenay, O</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 2: Ocean Technology, Policy & Non-Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Pollution Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Water science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabdasli, I</au><au>Guerel, M</au><au>Tuenay, O</au><au>Nyholm, N (eds)</au><au>Englande, AJ Jr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pollution prevention and waste treatment in chemical synthesis processes for pharmaceutical industry</atitle><jtitle>Water science and technology</jtitle><date>1999</date><risdate>1999</risdate><volume>39</volume><issue>10-11</issue><spage>265</spage><epage>271</epage><pages>265-271</pages><issn>0273-1223</issn><eissn>1996-9732</eissn><isbn>0080428185</isbn><isbn>9780080428185</isbn><coden>WSTED4</coden><abstract>Chemical synthesis processes of the pharmaceuticals industry produce wastewaters which are variable in character and highly strong. In-plant controls are important and highly effective in determining the final wastewater quality. At any rate several stages of treatment comprised of physical, chemical and biological are required to obtain a reasonable degree of treatment. The problem is further complicated in small-scale plants due to low volume of wastewaters and dilution requirements. In this study, a small-scale pharmaceuticals plant producing three common active materials was experimentally evaluated to assess the waste management alternatives. The processes were evaluated and a source-based pollution profile was prepared. Paracetamol wastewaters were found to be readily biodegradable. Omeprazole wastewaters could be biologically treated only after significant chemical treatment. Mephenoxalone wastewaters were in no case biologically degradable. Paracetamol and pretreated Omeprazole wastewaters could be biologically treated down to several hundreds of ppm COD at as high as 0.5 g COD/g VSS day F/M ratio after several fold dilution. Results of the study were evaluated and discussed.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/S0273-1223(99)00287-5</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0273-1223 |
| ispartof | Water science and technology, 1999, Vol.39 (10-11), p.265-271 |
| issn | 0273-1223 1996-9732 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analgesics Applied sciences Biodegradability Biodegradation Biological and medical sciences Biological treatability Biological treatment of waters Biological water treatment Biotechnology chemical oxidation Chemical oxygen demand Chemical synthesis chemical synthesis wastewaters Chemical treatment Chemical water treatment Dilution Drug products plants Drugs Environment and pollution Exact sciences and technology Fundamental and applied biological sciences. Psychology Industrial applications and implications. Economical aspects Industrial wastewaters mephenoxalone Mephenoxalone wastewaters Omeprazole Omeprazole wastewaters Oxidation Paracetamol Paracetamol wastewaters Pharmaceutical industry Pharmaceuticals pharmaceuticals industry Plants (botany) Pollution Pollution abatement Pollution prevention Waste management Waste treatment Wastewater Wastewater treatment Wastewaters Water pollution control Water treatment and pollution |
| title | Pollution prevention and waste treatment in chemical synthesis processes for pharmaceutical industry |
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