Factors Influencing Early Diagnosis and Poor Prognosis of Dysphagia After Senile Ischemic Stroke
Dysphagia is often a long-term problem after ischemic stroke, which are often accompanied by complications and results in poor outcome. This study aimed to investigate the influencing factors associated with the prognosis of dysphagia after senile ischemic stroke and evaluate the diagnostic performa...
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| Veröffentlicht in: | Journal of molecular neuroscience 2024-03, Vol.74 (2), p.31, Article 31 |
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| creator | Fan, Qingxian Zhao, Yan Zhang, Jianrong Wu, Yu’e Huang, Qingping Gao, Ying Wang, Jingqin Guo, Changqiong Zhang, Shuqing |
| description | Dysphagia is often a long-term problem after ischemic stroke, which are often accompanied by complications and results in poor outcome. This study aimed to investigate the influencing factors associated with the prognosis of dysphagia after senile ischemic stroke and evaluate the diagnostic performance of crucial factors. A total of 192 elderly ischemic stroke patients (96 patients without dysphagia with average age of 69.81 ± 4.61 years and 96 patients with dysphagia with average of 70.00 ± 6.66 years) were enrolled in the retrospective study. The clinical factors of the patients were collected and recorded for chi-square analysis and logistic analysis. The receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic performance of international normalized ratio (INR) and homocysteine (Hcy) in senile ischemic stroke patients. The age, cough reflex, history of stroke, mechanical ventilation, eating posture, insufficient elevation of the larynx, standard swallowing assessment (SSA) score, Hcy value, and INR were closely related to endpoint events of patients with dysphagia. The joint model (combined INR and Hcy value) can increase the area under the curve (AUC) value (0.948) with higher sensitivity and specificity for predicting patients with dysphagia occurred endpoint events. The influencing factors for older ischemic stroke patients with dysphagia include age, cough reflex, history of stroke, mechanical ventilation, eating posture, insufficient elevation of the larynx, SSA score, Hcy value, and INR. INR and Hcy were independent risk factors for prognosis and diagnostic markers for patients with dysphagia after senile ischemic stroke. |
| doi_str_mv | 10.1007/s12031-024-02210-w |
| format | Article |
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This study aimed to investigate the influencing factors associated with the prognosis of dysphagia after senile ischemic stroke and evaluate the diagnostic performance of crucial factors. A total of 192 elderly ischemic stroke patients (96 patients without dysphagia with average age of 69.81 ± 4.61 years and 96 patients with dysphagia with average of 70.00 ± 6.66 years) were enrolled in the retrospective study. The clinical factors of the patients were collected and recorded for chi-square analysis and logistic analysis. The receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic performance of international normalized ratio (INR) and homocysteine (Hcy) in senile ischemic stroke patients. The age, cough reflex, history of stroke, mechanical ventilation, eating posture, insufficient elevation of the larynx, standard swallowing assessment (SSA) score, Hcy value, and INR were closely related to endpoint events of patients with dysphagia. The joint model (combined INR and Hcy value) can increase the area under the curve (AUC) value (0.948) with higher sensitivity and specificity for predicting patients with dysphagia occurred endpoint events. The influencing factors for older ischemic stroke patients with dysphagia include age, cough reflex, history of stroke, mechanical ventilation, eating posture, insufficient elevation of the larynx, SSA score, Hcy value, and INR. INR and Hcy were independent risk factors for prognosis and diagnostic markers for patients with dysphagia after senile ischemic stroke.</description><identifier>ISSN: 1559-1166</identifier><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-024-02210-w</identifier><identifier>PMID: 38517611</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Age ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Chi-square test ; Cough ; Cough - complications ; Deglutition Disorders - diagnosis ; Deglutition Disorders - etiology ; Diagnostic systems ; Dysphagia ; Early Diagnosis ; Eating ; Homocysteine ; Humans ; Ischemia ; Ischemic Stroke ; Larynx ; Mechanical ventilation ; Neurochemistry ; Neurology ; Neurosciences ; Performance evaluation ; Posture ; Prognosis ; Proteomics ; Retrospective Studies ; Risk Factors ; ROC Curve ; Stroke ; Stroke - complications ; Stroke - diagnosis ; Ventilation</subject><ispartof>Journal of molecular neuroscience, 2024-03, Vol.74 (2), p.31, Article 31</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-c3c1e1fd79682dbd0b4adc0c835260ce4560473a8f636567366898ccbcdb99ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-024-02210-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-024-02210-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38517611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Qingxian</creatorcontrib><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Zhang, Jianrong</creatorcontrib><creatorcontrib>Wu, Yu’e</creatorcontrib><creatorcontrib>Huang, Qingping</creatorcontrib><creatorcontrib>Gao, Ying</creatorcontrib><creatorcontrib>Wang, Jingqin</creatorcontrib><creatorcontrib>Guo, Changqiong</creatorcontrib><creatorcontrib>Zhang, Shuqing</creatorcontrib><title>Factors Influencing Early Diagnosis and Poor Prognosis of Dysphagia After Senile Ischemic Stroke</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>Dysphagia is often a long-term problem after ischemic stroke, which are often accompanied by complications and results in poor outcome. This study aimed to investigate the influencing factors associated with the prognosis of dysphagia after senile ischemic stroke and evaluate the diagnostic performance of crucial factors. A total of 192 elderly ischemic stroke patients (96 patients without dysphagia with average age of 69.81 ± 4.61 years and 96 patients with dysphagia with average of 70.00 ± 6.66 years) were enrolled in the retrospective study. The clinical factors of the patients were collected and recorded for chi-square analysis and logistic analysis. The receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic performance of international normalized ratio (INR) and homocysteine (Hcy) in senile ischemic stroke patients. The age, cough reflex, history of stroke, mechanical ventilation, eating posture, insufficient elevation of the larynx, standard swallowing assessment (SSA) score, Hcy value, and INR were closely related to endpoint events of patients with dysphagia. The joint model (combined INR and Hcy value) can increase the area under the curve (AUC) value (0.948) with higher sensitivity and specificity for predicting patients with dysphagia occurred endpoint events. The influencing factors for older ischemic stroke patients with dysphagia include age, cough reflex, history of stroke, mechanical ventilation, eating posture, insufficient elevation of the larynx, SSA score, Hcy value, and INR. INR and Hcy were independent risk factors for prognosis and diagnostic markers for patients with dysphagia after senile ischemic stroke.</description><subject>Age</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Chi-square test</subject><subject>Cough</subject><subject>Cough - complications</subject><subject>Deglutition Disorders - diagnosis</subject><subject>Deglutition Disorders - etiology</subject><subject>Diagnostic systems</subject><subject>Dysphagia</subject><subject>Early Diagnosis</subject><subject>Eating</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Ischemic Stroke</subject><subject>Larynx</subject><subject>Mechanical ventilation</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Performance evaluation</subject><subject>Posture</subject><subject>Prognosis</subject><subject>Proteomics</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Stroke</subject><subject>Stroke - complications</subject><subject>Stroke - diagnosis</subject><subject>Ventilation</subject><issn>1559-1166</issn><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOxCAUhonReH8BF4bEjZsqB1raLiczXiaZRJPRNVJKa7UDI7SZzNuLdrzEhQvgBL7zH_IhdALkAghJLz1QwiAiNA6LAolWW2gfkiSPADjf_lXvoQPvXwihEEO2i_ZYlkDKAfbR07VUnXUeT03V9tqoxtT4Srp2jSeNrI31jcfSlPjeWofvnd1c2QpP1n75LOtG4lHVaYfn2jStxlOvnvWiUXjeOfuqj9BOJVuvjzfnIXq8vnoY30azu5vpeDSLFKO8C7sCDVWZ5jyjZVGSIpalIipjCeVE6TjhJE6ZzCrOeMJTxnmWZ0oVqizyXBbsEJ0PuUtn33rtO7FovNJtK422vRc0T2NCckjSgJ79QV9s70z43QfFwsQs5oGiA6Wc9d7pSixds5BuLYCID_9i8C-Cf_HpX6xC0-kmui8Wuvxu-RIeADYAPjyZWruf2f_EvgNhmJBb</recordid><startdate>20240322</startdate><enddate>20240322</enddate><creator>Fan, Qingxian</creator><creator>Zhao, Yan</creator><creator>Zhang, Jianrong</creator><creator>Wu, Yu’e</creator><creator>Huang, Qingping</creator><creator>Gao, Ying</creator><creator>Wang, Jingqin</creator><creator>Guo, Changqiong</creator><creator>Zhang, Shuqing</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240322</creationdate><title>Factors Influencing Early Diagnosis and Poor Prognosis of Dysphagia After Senile Ischemic Stroke</title><author>Fan, Qingxian ; 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This study aimed to investigate the influencing factors associated with the prognosis of dysphagia after senile ischemic stroke and evaluate the diagnostic performance of crucial factors. A total of 192 elderly ischemic stroke patients (96 patients without dysphagia with average age of 69.81 ± 4.61 years and 96 patients with dysphagia with average of 70.00 ± 6.66 years) were enrolled in the retrospective study. The clinical factors of the patients were collected and recorded for chi-square analysis and logistic analysis. The receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic performance of international normalized ratio (INR) and homocysteine (Hcy) in senile ischemic stroke patients. The age, cough reflex, history of stroke, mechanical ventilation, eating posture, insufficient elevation of the larynx, standard swallowing assessment (SSA) score, Hcy value, and INR were closely related to endpoint events of patients with dysphagia. The joint model (combined INR and Hcy value) can increase the area under the curve (AUC) value (0.948) with higher sensitivity and specificity for predicting patients with dysphagia occurred endpoint events. The influencing factors for older ischemic stroke patients with dysphagia include age, cough reflex, history of stroke, mechanical ventilation, eating posture, insufficient elevation of the larynx, SSA score, Hcy value, and INR. INR and Hcy were independent risk factors for prognosis and diagnostic markers for patients with dysphagia after senile ischemic stroke.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38517611</pmid><doi>10.1007/s12031-024-02210-w</doi></addata></record> |
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| subjects | Age Aged Biomedical and Life Sciences Biomedicine Cell Biology Chi-square test Cough Cough - complications Deglutition Disorders - diagnosis Deglutition Disorders - etiology Diagnostic systems Dysphagia Early Diagnosis Eating Homocysteine Humans Ischemia Ischemic Stroke Larynx Mechanical ventilation Neurochemistry Neurology Neurosciences Performance evaluation Posture Prognosis Proteomics Retrospective Studies Risk Factors ROC Curve Stroke Stroke - complications Stroke - diagnosis Ventilation |
| title | Factors Influencing Early Diagnosis and Poor Prognosis of Dysphagia After Senile Ischemic Stroke |
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