Purification and biochemical characterization of the G4 resolvase and DNA helicase FANCJ

G-quadruplex (G4) DNA or RNA poses a unique nucleic acid structure in genomic transactions. Because of the unique topology presented by G4, cells have exquisite mechanisms and pathways to metabolize G4 that arise in guanine-rich regions of the genome such as telomeres, promoter regions, ribosomal DN...

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Veröffentlicht in:	Methods in enzymology 2024, Vol.695, p.1
Hauptverfasser:	Kulikowicz, Tomasz, Sommers, Joshua A, Fuchs, Kathleen F, Wu, Yuliang, Brosh, Jr, Robert M
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - metabolism DNA Helicases - genetics DNA Helicases - metabolism DNA Repair DNA Replication Fanconi Anemia Complementation Group Proteins - genetics Fanconi Anemia Complementation Group Proteins - metabolism G-Quadruplexes Humans Recombinant Proteins - metabolism Recombinases - genetics Recombinases - metabolism
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