Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway

In pyloric metaplasia, mature gastric chief cells reprogram via an evolutionarily conserved process termed paligenosis to re-enter the cell cycle and become spasmolytic polypeptide-expressing metaplasia (SPEM) cells. Here, we use single-cell RNA sequencing (scRNA-seq) following injury to the murine...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Developmental cell 2024-05, Vol.59 (9), p.1175-1191.e7
Hauptverfasser:	Miao, Zhi-Feng, Sun, Jing-Xu, Huang, Xuan-Zhang, Bai, Shi, Pang, Min-Jiao, Li, Jia-Yi, Chen, Han-Yu, Tong, Qi-Yue, Ye, Shi-Yu, Wang, Xin-Yu, Hu, Xiao-Hai, Li, Jing-Ying, Zou, Jin-Wei, Xu, Wen, Yang, Jun-hao, Lu, Xi, Mills, Jason C., Wang, Zhen-Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - metabolism Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism Animals cerulein Chief Cells, Gastric - metabolism DMP777 ferroptosis Ferroptosis - physiology gastric metaplasia Gastric Mucosa - metabolism high-dose tamoxifen Intercellular Signaling Peptides and Proteins metabolic reprogramming Metaplasia - metabolism Mice Mice, Inbred C57BL Mice, Knockout mitochondria Mitochondria - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism paligenosis pancreatic acinar-ductal metaplasia Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Phospholipid Hydroperoxide Glutathione Peroxidase Reactive Oxygen Species - metabolism Regeneration - physiology Stomach - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!