Medical History and Preoperative Coagulation Profile as Predictors of Outcomes in Elective Spinal Surgery: A Meta-Analysis
In patients with unremarkable medical history, comprehensive preoperative hemostasis screening in elective neurosurgery remains debated. Comprehensive medical history has shown to be noninferior to coagulation profile to evaluate surgical outcomes. This study aims to evaluate the predictiveness of p...
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| Veröffentlicht in: | World neurosurgery 2024-05, Vol.185, p.e1294-e1308 |
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| creator | Pichardo-Rojas, Pavel S. Calvillo-Ramirez, Alejandro del Rio-Martinez, Christopher J. Fukumoto-Inukai, Kenzo A. Gonzalez-Hernandez, Diana Casas-Huesca, Ana Paulina Villarreal-Guerrero, Cristina Shah, Siddharth |
| description | In patients with unremarkable medical history, comprehensive preoperative hemostasis screening in elective neurosurgery remains debated. Comprehensive medical history has shown to be noninferior to coagulation profile to evaluate surgical outcomes. This study aims to evaluate the predictiveness of preoperative coagulation screening and medical history for surgical outcomes.
Databases were searched until April 2023 for observational cohort studies that reported preoperative hemostasis screening and clinical history prior to elective neurosurgical procedures. Outcomes of interest included postoperative transfusion, mortality, and complications. Pooled relative risk ratios (RRs) were analyzed using random-effects models.
Out of 604 studies, 3 cohort studies met our inclusion criteria, adding a patient population of 83,076. Prolonged partial thromboplastin time (PTT; RR=1.42, 95% confidence interval [CI] =1.14, 1.77, P=0.002), elevated international normalized ratio (INR; RR=2.01, 95% CI=1.14, 3.55, P=0.02), low platelet count (RR=1.58, 95% CI=1.34, 1.86, P |
| doi_str_mv | 10.1016/j.wneu.2024.03.074 |
| format | Article |
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Databases were searched until April 2023 for observational cohort studies that reported preoperative hemostasis screening and clinical history prior to elective neurosurgical procedures. Outcomes of interest included postoperative transfusion, mortality, and complications. Pooled relative risk ratios (RRs) were analyzed using random-effects models.
Out of 604 studies, 3 cohort studies met our inclusion criteria, adding a patient population of 83,076. Prolonged partial thromboplastin time (PTT; RR=1.42, 95% confidence interval [CI] =1.14, 1.77, P=0.002), elevated international normalized ratio (INR; RR=2.01, 95% CI=1.14, 3.55, P=0.02), low platelet count (RR=1.58, 95% CI=1.34, 1.86, P<0.00001), and positive bleeding history (RR=2.14, 95% CI=1.16, 3.93, P=0.01) were associated with postoperative transfusion risk. High PTT (RR=2.42, 95% CI=1.24, 4.73, P=0.010), High INR (RR=8.15, 95% CI=5.97, 11.13; P<0.00001), low platelet count (RR=4.89, 95% CI=3.73, 6.41, P<0.00001), and bleeding history (RR=7.59, 95% CI=5.84, 9.86, P<0.00001) were predictive of mortality. Prolonged PTT (RR=1.53, 95% CI=1.25, 1.86, P=<0.0001), a high INR (RR=3.41, 95% CI=2.63, 4.42, P=< 0.00001), low platelets (RR=1.63, 95% CI=1.40, 1.90, P=<0.00001), and medical history (RR=2.15, 95% CI=1.71, 2.71, P=<0.00001) were predictive of complications.
Medical history was a noninferior predictor to coagulation profile for postoperative transfusion, mortality, and complications. However, our findings are mostly representative of elective spinal procedures. Cost-effective alternatives should be explored to promote affordable patient care in patients with unremarkable history.]]></description><identifier>ISSN: 1878-8750</identifier><identifier>ISSN: 1878-8769</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2024.03.074</identifier><identifier>PMID: 38521219</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cost-effectiveness ; Neurosurgical procedures ; Preoperative coagulation profiling ; Surgical outcomes</subject><ispartof>World neurosurgery, 2024-05, Vol.185, p.e1294-e1308</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c307t-b73febcd0dbef2d4d14beefa76506b03d884f199baa6cc23bc2606b2aecd6c5f3</cites><orcidid>0009-0006-5484-7495 ; 0009-0005-6983-9116 ; 0000-0002-0804-2825 ; 0000-0002-6674-1501</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1878875024004595$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38521219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pichardo-Rojas, Pavel S.</creatorcontrib><creatorcontrib>Calvillo-Ramirez, Alejandro</creatorcontrib><creatorcontrib>del Rio-Martinez, Christopher J.</creatorcontrib><creatorcontrib>Fukumoto-Inukai, Kenzo A.</creatorcontrib><creatorcontrib>Gonzalez-Hernandez, Diana</creatorcontrib><creatorcontrib>Casas-Huesca, Ana Paulina</creatorcontrib><creatorcontrib>Villarreal-Guerrero, Cristina</creatorcontrib><creatorcontrib>Shah, Siddharth</creatorcontrib><title>Medical History and Preoperative Coagulation Profile as Predictors of Outcomes in Elective Spinal Surgery: A Meta-Analysis</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description><![CDATA[In patients with unremarkable medical history, comprehensive preoperative hemostasis screening in elective neurosurgery remains debated. Comprehensive medical history has shown to be noninferior to coagulation profile to evaluate surgical outcomes. This study aims to evaluate the predictiveness of preoperative coagulation screening and medical history for surgical outcomes.
Databases were searched until April 2023 for observational cohort studies that reported preoperative hemostasis screening and clinical history prior to elective neurosurgical procedures. Outcomes of interest included postoperative transfusion, mortality, and complications. Pooled relative risk ratios (RRs) were analyzed using random-effects models.
Out of 604 studies, 3 cohort studies met our inclusion criteria, adding a patient population of 83,076. Prolonged partial thromboplastin time (PTT; RR=1.42, 95% confidence interval [CI] =1.14, 1.77, P=0.002), elevated international normalized ratio (INR; RR=2.01, 95% CI=1.14, 3.55, P=0.02), low platelet count (RR=1.58, 95% CI=1.34, 1.86, P<0.00001), and positive bleeding history (RR=2.14, 95% CI=1.16, 3.93, P=0.01) were associated with postoperative transfusion risk. High PTT (RR=2.42, 95% CI=1.24, 4.73, P=0.010), High INR (RR=8.15, 95% CI=5.97, 11.13; P<0.00001), low platelet count (RR=4.89, 95% CI=3.73, 6.41, P<0.00001), and bleeding history (RR=7.59, 95% CI=5.84, 9.86, P<0.00001) were predictive of mortality. Prolonged PTT (RR=1.53, 95% CI=1.25, 1.86, P=<0.0001), a high INR (RR=3.41, 95% CI=2.63, 4.42, P=< 0.00001), low platelets (RR=1.63, 95% CI=1.40, 1.90, P=<0.00001), and medical history (RR=2.15, 95% CI=1.71, 2.71, P=<0.00001) were predictive of complications.
Medical history was a noninferior predictor to coagulation profile for postoperative transfusion, mortality, and complications. However, our findings are mostly representative of elective spinal procedures. Cost-effective alternatives should be explored to promote affordable patient care in patients with unremarkable history.]]></description><subject>Cost-effectiveness</subject><subject>Neurosurgical procedures</subject><subject>Preoperative coagulation profiling</subject><subject>Surgical outcomes</subject><issn>1878-8750</issn><issn>1878-8769</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kEFv2yAYhlG1qq3S_IEeKo672PsAx9jVLlHUrZNadVLXM8LwURE5JgO7U_brR5Ysx3HhE9_7vBIPITcMSgas_rQufw04lRx4VYIoQVZn5Io1sikaWbcfTvMCLsk8pTXkI1jVSHFBLkWz4Iyz9or8fkLrje7pg09jiDuqB0u_RwxbjHr070hXQb9NfZ7DkBfB-R6pTvtMBjOSaHD0eRpN2GCifqD3PZq_5MvWD7n5ZYpvGHd3dEmfcNTFMj_ukk_X5NzpPuH8eM_I65f7H6uH4vH567fV8rEwAuRYdFI47IwF26HjtrKs6hCdlvUC6g6EbZrKsbbttK6N4aIzvM4LrtHY2iycmJGPh95tDD8nTKPa-GSw7_WAYUqKt7ICkNBAjvJD1MSQUkSnttFvdNwpBmqvXa3VXrvaa1cgVNaeodtj_9Rt0J6Qf5Jz4PMhgPmX7x6jSsbjYLLAmFUpG_z_-v8Aw6qWfA</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Pichardo-Rojas, Pavel S.</creator><creator>Calvillo-Ramirez, Alejandro</creator><creator>del Rio-Martinez, Christopher J.</creator><creator>Fukumoto-Inukai, Kenzo A.</creator><creator>Gonzalez-Hernandez, Diana</creator><creator>Casas-Huesca, Ana Paulina</creator><creator>Villarreal-Guerrero, Cristina</creator><creator>Shah, Siddharth</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0006-5484-7495</orcidid><orcidid>https://orcid.org/0009-0005-6983-9116</orcidid><orcidid>https://orcid.org/0000-0002-0804-2825</orcidid><orcidid>https://orcid.org/0000-0002-6674-1501</orcidid></search><sort><creationdate>20240501</creationdate><title>Medical History and Preoperative Coagulation Profile as Predictors of Outcomes in Elective Spinal Surgery: A Meta-Analysis</title><author>Pichardo-Rojas, Pavel S. ; Calvillo-Ramirez, Alejandro ; del Rio-Martinez, Christopher J. ; Fukumoto-Inukai, Kenzo A. ; Gonzalez-Hernandez, Diana ; Casas-Huesca, Ana Paulina ; Villarreal-Guerrero, Cristina ; Shah, Siddharth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-b73febcd0dbef2d4d14beefa76506b03d884f199baa6cc23bc2606b2aecd6c5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cost-effectiveness</topic><topic>Neurosurgical procedures</topic><topic>Preoperative coagulation profiling</topic><topic>Surgical outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pichardo-Rojas, Pavel S.</creatorcontrib><creatorcontrib>Calvillo-Ramirez, Alejandro</creatorcontrib><creatorcontrib>del Rio-Martinez, Christopher J.</creatorcontrib><creatorcontrib>Fukumoto-Inukai, Kenzo A.</creatorcontrib><creatorcontrib>Gonzalez-Hernandez, Diana</creatorcontrib><creatorcontrib>Casas-Huesca, Ana Paulina</creatorcontrib><creatorcontrib>Villarreal-Guerrero, Cristina</creatorcontrib><creatorcontrib>Shah, Siddharth</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pichardo-Rojas, Pavel S.</au><au>Calvillo-Ramirez, Alejandro</au><au>del Rio-Martinez, Christopher J.</au><au>Fukumoto-Inukai, Kenzo A.</au><au>Gonzalez-Hernandez, Diana</au><au>Casas-Huesca, Ana Paulina</au><au>Villarreal-Guerrero, Cristina</au><au>Shah, Siddharth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medical History and Preoperative Coagulation Profile as Predictors of Outcomes in Elective Spinal Surgery: A Meta-Analysis</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>185</volume><spage>e1294</spage><epage>e1308</epage><pages>e1294-e1308</pages><issn>1878-8750</issn><issn>1878-8769</issn><eissn>1878-8769</eissn><abstract><![CDATA[In patients with unremarkable medical history, comprehensive preoperative hemostasis screening in elective neurosurgery remains debated. Comprehensive medical history has shown to be noninferior to coagulation profile to evaluate surgical outcomes. This study aims to evaluate the predictiveness of preoperative coagulation screening and medical history for surgical outcomes.
Databases were searched until April 2023 for observational cohort studies that reported preoperative hemostasis screening and clinical history prior to elective neurosurgical procedures. Outcomes of interest included postoperative transfusion, mortality, and complications. Pooled relative risk ratios (RRs) were analyzed using random-effects models.
Out of 604 studies, 3 cohort studies met our inclusion criteria, adding a patient population of 83,076. Prolonged partial thromboplastin time (PTT; RR=1.42, 95% confidence interval [CI] =1.14, 1.77, P=0.002), elevated international normalized ratio (INR; RR=2.01, 95% CI=1.14, 3.55, P=0.02), low platelet count (RR=1.58, 95% CI=1.34, 1.86, P<0.00001), and positive bleeding history (RR=2.14, 95% CI=1.16, 3.93, P=0.01) were associated with postoperative transfusion risk. High PTT (RR=2.42, 95% CI=1.24, 4.73, P=0.010), High INR (RR=8.15, 95% CI=5.97, 11.13; P<0.00001), low platelet count (RR=4.89, 95% CI=3.73, 6.41, P<0.00001), and bleeding history (RR=7.59, 95% CI=5.84, 9.86, P<0.00001) were predictive of mortality. Prolonged PTT (RR=1.53, 95% CI=1.25, 1.86, P=<0.0001), a high INR (RR=3.41, 95% CI=2.63, 4.42, P=< 0.00001), low platelets (RR=1.63, 95% CI=1.40, 1.90, P=<0.00001), and medical history (RR=2.15, 95% CI=1.71, 2.71, P=<0.00001) were predictive of complications.
Medical history was a noninferior predictor to coagulation profile for postoperative transfusion, mortality, and complications. However, our findings are mostly representative of elective spinal procedures. Cost-effective alternatives should be explored to promote affordable patient care in patients with unremarkable history.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38521219</pmid><doi>10.1016/j.wneu.2024.03.074</doi><orcidid>https://orcid.org/0009-0006-5484-7495</orcidid><orcidid>https://orcid.org/0009-0005-6983-9116</orcidid><orcidid>https://orcid.org/0000-0002-0804-2825</orcidid><orcidid>https://orcid.org/0000-0002-6674-1501</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Cost-effectiveness Neurosurgical procedures Preoperative coagulation profiling Surgical outcomes |
| title | Medical History and Preoperative Coagulation Profile as Predictors of Outcomes in Elective Spinal Surgery: A Meta-Analysis |
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