The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration

•CpG dinucleotides in the AAV vector genome negatively impacts gene transfer and expression.•With an antibody-encoding transgene, this effect is observed at 24 h after AAV administration.•Plasmacytoid DC-like myeloid cells expressing Fc receptor are activated after AAV administration. AAV-mediated g...

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