Clinical features and risk factors of primary Sjögren’s syndrome complicated with severe pneumonia: a case–control study
Objectives To analyze clinical characteristics, risk factors, pathogen distribution, and prognostic markers in primary Sjögren’s syndrome (pSS) patients with severe pneumonia (SP) compared to those without severe pneumonia (NSP). Methods This case–control study included 24 hospitalized pSS patients...
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| Veröffentlicht in: | Clinical rheumatology 2024-05, Vol.43 (5), p.1665-1674 |
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| creator | Cai, Bo Guo, Zhiliang Yan, Qing Li, Hui Song, Hua Gong, Yan Long, Xianming |
| description | Objectives
To analyze clinical characteristics, risk factors, pathogen distribution, and prognostic markers in primary Sjögren’s syndrome (pSS) patients with severe pneumonia (SP) compared to those without severe pneumonia (NSP).
Methods
This case–control study included 24 hospitalized pSS patients with SP and 96 NSP at the first affiliated hospital of Soochow university from June 2014 to May 2023. Data encompassing demographics, comorbidities, treatments, and laboratory results were retrospectively collected. Univariate and multivariate regression analyses, ROC curves, and statistical analyses using SPSS 23.0 assessed risk factors. The study retrospectively analyzed clinical features and risk factors, highlighting distinct parameters between pSS patients with and without SP.
Results
Marked differences were observed in several parameters: pSS activity(
P
|
| doi_str_mv | 10.1007/s10067-024-06942-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2974006353</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3153587376</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-19c17e0316af7ced0e422cd6748fabf86ef676b33f92d7f8640b5c6b3d2850f23</originalsourceid><addsrcrecordid>eNqFkcuKFDEUhoMoTjv6Ai4k4MZNaW6ViztpvMGAC3Ud0snJWG1V0iZVSi-EeQdXvogv4JvMk5ixWwUXCiEhyXf-kPMhdJeSh5QQ9ai2WaqOMNERaQTr-DW0ooKLzhhhrqMVUYp0nBp9gm7VuiWEMG3oTXTCdU9ZGyv0eT0OafBuxBHcvBSo2KWAy1Df4-j8nEvFOeJdGSZX9vj19vu38wLp8uJrxXWfQskTYJ-n3dhCZgj40zC_wxU-QgG8S7BMOQ3uMXbYuwqXF198TnPJI67zEva30Y3oxgp3juspevvs6Zv1i-7s1fOX6ydnnee9mTtqPFVAOJUuKg-BgGDMB6mEjm4TtYQoldxwHg0Lqu0F2fS-HQSmexIZP0UPDrm7kj8sUGc7DdXDOLoEeamW0573WnEl_4syo0RrO-95Q-__hW7zUlL7iOWEayG10LpR7ED5kmstEO2xmZYSe-XRHjza5tH-9Givou8do5fNBOF3yS9xDeAHoLardA7lz9v_iP0BKoWsOQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3038468488</pqid></control><display><type>article</type><title>Clinical features and risk factors of primary Sjögren’s syndrome complicated with severe pneumonia: a case–control study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Cai, Bo ; Guo, Zhiliang ; Yan, Qing ; Li, Hui ; Song, Hua ; Gong, Yan ; Long, Xianming</creator><creatorcontrib>Cai, Bo ; Guo, Zhiliang ; Yan, Qing ; Li, Hui ; Song, Hua ; Gong, Yan ; Long, Xianming</creatorcontrib><description>Objectives
To analyze clinical characteristics, risk factors, pathogen distribution, and prognostic markers in primary Sjögren’s syndrome (pSS) patients with severe pneumonia (SP) compared to those without severe pneumonia (NSP).
Methods
This case–control study included 24 hospitalized pSS patients with SP and 96 NSP at the first affiliated hospital of Soochow university from June 2014 to May 2023. Data encompassing demographics, comorbidities, treatments, and laboratory results were retrospectively collected. Univariate and multivariate regression analyses, ROC curves, and statistical analyses using SPSS 23.0 assessed risk factors. The study retrospectively analyzed clinical features and risk factors, highlighting distinct parameters between pSS patients with and without SP.
Results
Marked differences were observed in several parameters: pSS activity(
P
< 0.001), white blood cell (
P
= 0.043), lymphocyte (
P
< 0.001), neutrophils (
P
= 0.042), C-reactive protein (
P
= 0.042), and CD8
+
T cell (
P
= 0.017). Notably, lymphocyte count and SS activity demonstrated robust discrimination ability (AUC > 0.85). C-reactive protein (CRP), procalcitonin, CD4
+
T cell, and IgA showed significant associations with SP; higher CRP levels correlated with increased risk, while lower CD4
+
T cell and IgA levels associated with increased risk. SS activity significantly impacted outcomes. Various biomarkers exhibited diverse discriminatory abilities but lacked strong predictive associations with outcomes.
Conclusion
pSS patients with SP exhibited higher disease activity and altered immune profiles compared to those NSP. Lymphocyte count and SS activity emerged as robust discriminators. Higher CRP levels correlated with increased risk of SP, while lower CD4
+
T cell and IgA levels associated with increased risk. SS activity significantly impacted patient outcomes.
Key Points
• pSS patients with SP exhibited higher disease activity and altered immune profiles compared to those NSP.
• Lymphocyte count and SS activity emerged as robust discriminators.
• Higher CRP levels correlated with increased risk of SP, while lower CD4+ T cell and IgA levels associated with decreased risk.
• SS activity significantly impacted patient outcomes.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-024-06942-3</identifier><identifier>PMID: 38512512</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>biomarkers ; C-Reactive Protein ; Case-Control Studies ; CD4 antigen ; CD4-positive T-lymphocytes ; CD8 antigen ; Cell number ; Clinical outcomes ; Comorbidity ; demographic statistics ; hospitals ; Humans ; Immunoglobulin A ; Leukocytes (neutrophilic) ; lymphocyte count ; Lymphocytes ; Lymphocytes T ; Medicine ; Medicine & Public Health ; neutrophils ; Original Article ; pathogens ; Patients ; Pneumonia ; Procalcitonin ; Retrospective Studies ; Rheumatology ; risk ; Risk Factors ; risk reduction ; Sjogren's Syndrome ; Statistical analysis</subject><ispartof>Clinical rheumatology, 2024-05, Vol.43 (5), p.1665-1674</ispartof><rights>The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-19c17e0316af7ced0e422cd6748fabf86ef676b33f92d7f8640b5c6b3d2850f23</cites><orcidid>0000-0001-7233-4358</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-024-06942-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-024-06942-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38512512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Bo</creatorcontrib><creatorcontrib>Guo, Zhiliang</creatorcontrib><creatorcontrib>Yan, Qing</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Song, Hua</creatorcontrib><creatorcontrib>Gong, Yan</creatorcontrib><creatorcontrib>Long, Xianming</creatorcontrib><title>Clinical features and risk factors of primary Sjögren’s syndrome complicated with severe pneumonia: a case–control study</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Objectives
To analyze clinical characteristics, risk factors, pathogen distribution, and prognostic markers in primary Sjögren’s syndrome (pSS) patients with severe pneumonia (SP) compared to those without severe pneumonia (NSP).
Methods
This case–control study included 24 hospitalized pSS patients with SP and 96 NSP at the first affiliated hospital of Soochow university from June 2014 to May 2023. Data encompassing demographics, comorbidities, treatments, and laboratory results were retrospectively collected. Univariate and multivariate regression analyses, ROC curves, and statistical analyses using SPSS 23.0 assessed risk factors. The study retrospectively analyzed clinical features and risk factors, highlighting distinct parameters between pSS patients with and without SP.
Results
Marked differences were observed in several parameters: pSS activity(
P
< 0.001), white blood cell (
P
= 0.043), lymphocyte (
P
< 0.001), neutrophils (
P
= 0.042), C-reactive protein (
P
= 0.042), and CD8
+
T cell (
P
= 0.017). Notably, lymphocyte count and SS activity demonstrated robust discrimination ability (AUC > 0.85). C-reactive protein (CRP), procalcitonin, CD4
+
T cell, and IgA showed significant associations with SP; higher CRP levels correlated with increased risk, while lower CD4
+
T cell and IgA levels associated with increased risk. SS activity significantly impacted outcomes. Various biomarkers exhibited diverse discriminatory abilities but lacked strong predictive associations with outcomes.
Conclusion
pSS patients with SP exhibited higher disease activity and altered immune profiles compared to those NSP. Lymphocyte count and SS activity emerged as robust discriminators. Higher CRP levels correlated with increased risk of SP, while lower CD4
+
T cell and IgA levels associated with increased risk. SS activity significantly impacted patient outcomes.
Key Points
• pSS patients with SP exhibited higher disease activity and altered immune profiles compared to those NSP.
• Lymphocyte count and SS activity emerged as robust discriminators.
• Higher CRP levels correlated with increased risk of SP, while lower CD4+ T cell and IgA levels associated with decreased risk.
• SS activity significantly impacted patient outcomes.</description><subject>biomarkers</subject><subject>C-Reactive Protein</subject><subject>Case-Control Studies</subject><subject>CD4 antigen</subject><subject>CD4-positive T-lymphocytes</subject><subject>CD8 antigen</subject><subject>Cell number</subject><subject>Clinical outcomes</subject><subject>Comorbidity</subject><subject>demographic statistics</subject><subject>hospitals</subject><subject>Humans</subject><subject>Immunoglobulin A</subject><subject>Leukocytes (neutrophilic)</subject><subject>lymphocyte count</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>neutrophils</subject><subject>Original Article</subject><subject>pathogens</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Procalcitonin</subject><subject>Retrospective Studies</subject><subject>Rheumatology</subject><subject>risk</subject><subject>Risk Factors</subject><subject>risk reduction</subject><subject>Sjogren's Syndrome</subject><subject>Statistical analysis</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuKFDEUhoMoTjv6Ai4k4MZNaW6ViztpvMGAC3Ud0snJWG1V0iZVSi-EeQdXvogv4JvMk5ixWwUXCiEhyXf-kPMhdJeSh5QQ9ai2WaqOMNERaQTr-DW0ooKLzhhhrqMVUYp0nBp9gm7VuiWEMG3oTXTCdU9ZGyv0eT0OafBuxBHcvBSo2KWAy1Df4-j8nEvFOeJdGSZX9vj19vu38wLp8uJrxXWfQskTYJ-n3dhCZgj40zC_wxU-QgG8S7BMOQ3uMXbYuwqXF198TnPJI67zEva30Y3oxgp3juspevvs6Zv1i-7s1fOX6ydnnee9mTtqPFVAOJUuKg-BgGDMB6mEjm4TtYQoldxwHg0Lqu0F2fS-HQSmexIZP0UPDrm7kj8sUGc7DdXDOLoEeamW0573WnEl_4syo0RrO-95Q-__hW7zUlL7iOWEayG10LpR7ED5kmstEO2xmZYSe-XRHjza5tH-9Givou8do5fNBOF3yS9xDeAHoLardA7lz9v_iP0BKoWsOQ</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Cai, Bo</creator><creator>Guo, Zhiliang</creator><creator>Yan, Qing</creator><creator>Li, Hui</creator><creator>Song, Hua</creator><creator>Gong, Yan</creator><creator>Long, Xianming</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-7233-4358</orcidid></search><sort><creationdate>20240501</creationdate><title>Clinical features and risk factors of primary Sjögren’s syndrome complicated with severe pneumonia: a case–control study</title><author>Cai, Bo ; Guo, Zhiliang ; Yan, Qing ; Li, Hui ; Song, Hua ; Gong, Yan ; Long, Xianming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-19c17e0316af7ced0e422cd6748fabf86ef676b33f92d7f8640b5c6b3d2850f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>biomarkers</topic><topic>C-Reactive Protein</topic><topic>Case-Control Studies</topic><topic>CD4 antigen</topic><topic>CD4-positive T-lymphocytes</topic><topic>CD8 antigen</topic><topic>Cell number</topic><topic>Clinical outcomes</topic><topic>Comorbidity</topic><topic>demographic statistics</topic><topic>hospitals</topic><topic>Humans</topic><topic>Immunoglobulin A</topic><topic>Leukocytes (neutrophilic)</topic><topic>lymphocyte count</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>neutrophils</topic><topic>Original Article</topic><topic>pathogens</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Procalcitonin</topic><topic>Retrospective Studies</topic><topic>Rheumatology</topic><topic>risk</topic><topic>Risk Factors</topic><topic>risk reduction</topic><topic>Sjogren's Syndrome</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Bo</creatorcontrib><creatorcontrib>Guo, Zhiliang</creatorcontrib><creatorcontrib>Yan, Qing</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Song, Hua</creatorcontrib><creatorcontrib>Gong, Yan</creatorcontrib><creatorcontrib>Long, Xianming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Bo</au><au>Guo, Zhiliang</au><au>Yan, Qing</au><au>Li, Hui</au><au>Song, Hua</au><au>Gong, Yan</au><au>Long, Xianming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical features and risk factors of primary Sjögren’s syndrome complicated with severe pneumonia: a case–control study</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>43</volume><issue>5</issue><spage>1665</spage><epage>1674</epage><pages>1665-1674</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Objectives
To analyze clinical characteristics, risk factors, pathogen distribution, and prognostic markers in primary Sjögren’s syndrome (pSS) patients with severe pneumonia (SP) compared to those without severe pneumonia (NSP).
Methods
This case–control study included 24 hospitalized pSS patients with SP and 96 NSP at the first affiliated hospital of Soochow university from June 2014 to May 2023. Data encompassing demographics, comorbidities, treatments, and laboratory results were retrospectively collected. Univariate and multivariate regression analyses, ROC curves, and statistical analyses using SPSS 23.0 assessed risk factors. The study retrospectively analyzed clinical features and risk factors, highlighting distinct parameters between pSS patients with and without SP.
Results
Marked differences were observed in several parameters: pSS activity(
P
< 0.001), white blood cell (
P
= 0.043), lymphocyte (
P
< 0.001), neutrophils (
P
= 0.042), C-reactive protein (
P
= 0.042), and CD8
+
T cell (
P
= 0.017). Notably, lymphocyte count and SS activity demonstrated robust discrimination ability (AUC > 0.85). C-reactive protein (CRP), procalcitonin, CD4
+
T cell, and IgA showed significant associations with SP; higher CRP levels correlated with increased risk, while lower CD4
+
T cell and IgA levels associated with increased risk. SS activity significantly impacted outcomes. Various biomarkers exhibited diverse discriminatory abilities but lacked strong predictive associations with outcomes.
Conclusion
pSS patients with SP exhibited higher disease activity and altered immune profiles compared to those NSP. Lymphocyte count and SS activity emerged as robust discriminators. Higher CRP levels correlated with increased risk of SP, while lower CD4
+
T cell and IgA levels associated with increased risk. SS activity significantly impacted patient outcomes.
Key Points
• pSS patients with SP exhibited higher disease activity and altered immune profiles compared to those NSP.
• Lymphocyte count and SS activity emerged as robust discriminators.
• Higher CRP levels correlated with increased risk of SP, while lower CD4+ T cell and IgA levels associated with decreased risk.
• SS activity significantly impacted patient outcomes.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38512512</pmid><doi>10.1007/s10067-024-06942-3</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7233-4358</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical rheumatology, 2024-05, Vol.43 (5), p.1665-1674 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | biomarkers C-Reactive Protein Case-Control Studies CD4 antigen CD4-positive T-lymphocytes CD8 antigen Cell number Clinical outcomes Comorbidity demographic statistics hospitals Humans Immunoglobulin A Leukocytes (neutrophilic) lymphocyte count Lymphocytes Lymphocytes T Medicine Medicine & Public Health neutrophils Original Article pathogens Patients Pneumonia Procalcitonin Retrospective Studies Rheumatology risk Risk Factors risk reduction Sjogren's Syndrome Statistical analysis |
| title | Clinical features and risk factors of primary Sjögren’s syndrome complicated with severe pneumonia: a case–control study |
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