AQP4 Endocytosis-Lysosome Degradation Mediated by MMP-9/β-DG Involved in Diabetes Cognitive Impairment

Cognitive impairment is considered to be one of the important comorbidities of diabetes, but the underlying mechanisms are widely unknown. Aquaporin-4 (AQP4) is the most abundant water channel in the central nervous system, which plays a neuroprotective role in various neurological diseases by maint...

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Veröffentlicht in:	Molecular neurobiology 2024-10, Vol.61 (10), p.8438-8453
Hauptverfasser:	Yuan, Ye, Peng, Wei, Lei, Jingna, Zhao, Yi, Zhao, Beiyu, Li, Yan, Wang, Jin, Qu, Qiumin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaporin 4 Aquaporin 4 - metabolism Astrocytes Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system Cognitive ability Cognitive Dysfunction - metabolism Comorbidity Degradation Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Dystroglycan Dystroglycans - metabolism Endocytosis Gelatinase B Lysosomes Lysosomes - metabolism Male Matrix metalloproteinase Matrix Metalloproteinase 9 - metabolism Metalloproteinase Mice Mice, Inbred C57BL Neurobiology Neurological diseases Neurology Neuroprotection Neurosciences Prefrontal cortex Proteolysis - drug effects Synaptic plasticity Therapeutic targets
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