Magnolol derivatives as specific and noncytotoxic inhibitors of breast cancer resistance protein (BCRP/ABCG2)

[Display omitted] •13 magnolol derivatives were tested as ABCG2 inhibitors.•The monomethoxylated magnolol derivative 11 showed complete ABCG2 inhibition.•Magnolol derivative 11 was not transported, noncytotoxic, and showed a specific ABCG2 inhibition. The breast cancer resistance protein (BCRP/ABCG2...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic chemistry 2024-05, Vol.146, p.107283-107283, Article 107283
Hauptverfasser:	da Silva Zanzarini, Isadora, Henrique Kita, Diogo, Scheiffer, Gustavo, Karoline dos Santos, Kelly, de Paula Dutra, Julia, Augusto Pastore, Matteo, Gomes de Moraes Rego, Fabiane, Picheth, Geraldo, Ambudkar, Suresh V., Pulvirenti, Luana, Cardullo, Nunzio, Rotuno Moure, Vivian, Muccilli, Vera, Tringali, Corrado, Valdameri, Glaucio
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters ABCG2 Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology ATP Binding Cassette Transporter, Subfamily G, Member 2 Biphenyl Compounds Breast Neoplasms Drug Resistance, Neoplasm Female Humans Inhibitors Lignans Magnolol Multidrug resistance Neoplasm Proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!