Using Drosophila amyloid toxicity models to study Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent form of dementia and is characterised by a progressive loss of neurons, which manifests as gradual memory decline, followed by cognitive loss. Despite the significant progress in identifying novel biomarkers and understanding the prodromal patholog...

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Veröffentlicht in:	Annals of human genetics 2024-09, Vol.88 (5), p.349-363
Hauptverfasser:	Tsintzas, Elli, Niccoli, Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer's disease Amyloid amyloid beta Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism amyloid precursor protein Animals Dementia disorders Disease Models, Animal Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Drug development FDA approval GeneSwitch Humans Insects Life span Neurodegeneration Neurodegenerative diseases Neurosciences Therapeutic applications Therapeutic targets Toxicity β-Amyloid
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