Age‐related cholesterol and colorectal cancer progression: Validating squalene epoxidase for high‐risk cases

As people age, the risk and progression of colorectal cancer (CRC), along with cholesterol levels, tend to increase. Nevertheless, epidemiological studies on serum lipids and CRC have produced conflicting results. We previously demonstrated that the reduction of squalene epoxidase (SQLE) due to accu...

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Veröffentlicht in:	Aging cell 2024-07, Vol.23 (7), p.e14152-n/a
Hauptverfasser:	Jun, Soo Young, Yoon, Hyang Ran, Yoon, Ji‐Yong, Lee, Jeong‐Ju, Kim, Ji Yeon, Kim, Jin‐Man, Kim, Nam‐Soon
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aging Aging - metabolism Biomarkers Biosynthesis Candidates Cell activation Cholesterol Cholesterol - metabolism Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Disease Progression Epidemiology Fatalities Female Humans Image processing Immunohistochemistry Lipids Machine learning machine learning‐based digital image analysis combined with fluorescence‐immunohistochemistry Male Middle Aged Patients Phosphorylation Proteins Risk Factors Serum lipids Squalene Squalene epoxidase Squalene Monooxygenase - genetics Squalene Monooxygenase - metabolism β-Catenin
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