GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation

Disturbances in intestinal immune homeostasis predispose susceptible individuals to type 1 diabetes (T1D). G-protein-coupled receptor 41 (GPR41) is a receptor for short-chain fatty acids (SCFAs) mainly produced by gut microbiota, which plays key roles in maintaining intestinal homeostasis. In this s...

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Veröffentlicht in:	Acta pharmacologica Sinica 2024-07, Vol.45 (7), p.1466-1476
Hauptverfasser:	Li, Jia-hong, Zhang, Ming, Zhang, Zhao-di, Pan, Xiao-hua, Pan, Li-long, Sun, Jia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Dendritic Cells - immunology Dendritic Cells - metabolism Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - metabolism Female Gastrointestinal Microbiome Immunology Interferon-gamma - metabolism Internal Medicine Male Medical Microbiology Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Pancreas - immunology Pancreas - metabolism Pancreas - pathology Pharmacology/Toxicology Receptors, G-Protein-Coupled - deficiency Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism STAT3 Transcription Factor - metabolism Streptozocin Suppressor of Cytokine Signaling 3 Protein - genetics Suppressor of Cytokine Signaling 3 Protein - metabolism Vaccine
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