Stem cell factor and cKIT modulate endothelial glycolysis in hypoxia

In hypoxia, endothelial cells (ECs) proliferate, migrate, and form new vasculature in a process called angiogenesis. Recent studies have suggested that ECs rely on glycolysis to meet metabolic needs for angiogenesis in ischaemic tissues, and several studies have investigated the molecular mechanisms...

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Veröffentlicht in:	Cardiovascular research 2024-05, Vol.120 (7), p.745-755
Hauptverfasser:	Jeong, Hayoung, Kim, Ryul-I, Koo, Hyunwoo, Choi, Yang Hee, Kim, Minju, Roh, Hyejin, Park, Sang Gyu, Sung, Jong-Hyuk, Kim, Koung Li, Suh, Wonhee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Hypoxia Cells, Cultured Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Glucose - metabolism Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Glycolysis Human Umbilical Vein Endothelial Cells - metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Mice, Inbred C57BL Neovascularization, Physiologic Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Signal Transduction Stem Cell Factor - genetics Stem Cell Factor - metabolism
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