Engineered hsa‐miR‐455‐3p‐Abundant Extracellular Vesicles Derived from 3D‐Cultured Adipose Mesenchymal Stem Cells for Tissue‐Engineering Hyaline Cartilage Regeneration

Efforts are made to enhance the inherent potential of extracellular vesicles (EVs) by utilizing 3D culture platforms and engineered strategies for functional cargo‐loading. Three distinct types of adipose mesenchymal stem cells‐derived EVs (ADSCs‐EVs) are successfully isolated utilizing 3D culture p...

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Veröffentlicht in:	Advanced healthcare materials 2024-07, Vol.13 (18), p.e2304194-n/a
Hauptverfasser:	Chen, Jian‐Guo, Zhang, En‐Chong, Wan, Ying‐Ying, Huang, Tian‐Yu, Wang, Yu‐Chen, Jiang, Hai‐Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	3D culture adipose mesenchymal stem cells Adipose Tissue - cytology Animals Cartilage Cell culture Cell Culture Techniques, Three Dimensional - methods Cells, Cultured Chondrocytes Chondrocytes - cytology Chondrocytes - metabolism Chondrogenesis Chondroitin sulfate Electroporation Encapsulation Extracellular vesicles Extracellular Vesicles - chemistry Extracellular Vesicles - metabolism Gelatin Gelatin - chemistry hsa‐miR‐455‐3p/PAK2/Smad2/3 axis Humans Hyaline Cartilage - metabolism Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Platforms Regeneration Smad2 protein Smad2 Protein - metabolism Smad3 Protein - metabolism Stem cells Three axis Tissue engineering Tissue Engineering - methods tissue‐engineering hyaline cartilage Transfection Vesicles
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