CD93 regulates breast cancer growth and vasculogenic mimicry through the PI3K/AKT/SP2 signaling pathway activated by integrin β1

In women, breast cancer (BC) accounts for 7%–10% of all cancer cases and is one of the most common cancers. To identify a new method for treating BC, the role of CD93 and its underlying mechanism were explored. MDA‐MB‐231 cells were used in this study and transfected with si‐CD93, si‐MMRN2, oe‐CD93,...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2024-04, Vol.38 (4), p.e23688-n/a
Hauptverfasser:	Liu, Hong, Zhang, Jianhui, Zhao, Yanjun, Fan, Zhixiong, Yang, Yongheng, Mao, Yuanyuan, Yang, Jingyuan, Ma, Shungao
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Animal models Animals Breast cancer Breast Neoplasms - pathology CD93 Cell Line, Tumor Cell migration Cell Proliferation Female Gene expression Humans Immunofluorescence Immunohistochemistry Integrin beta1 - genetics Integrin beta1 - metabolism integrin β1 Membrane Glycoproteins - metabolism Mice Mice, Nude Mimicry Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT/SP2 signaling pathway Proto-Oncogene Proteins c-akt - metabolism Receptors, Complement - metabolism Signal Transduction vasculogenic mimicry
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