Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures
Purpose This study was designed to assess the pituitary functions of patients with traumatic maxillofacial fractures and compare the results with healthy controls. Methods Thirty patients (mean age, 38.14 ± 14.15 years; twenty-six male, four female) with a traumatic maxillofacial fracture at least 1...
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| Veröffentlicht in: | Journal of endocrinological investigation 2024-10, Vol.47 (10), p.2477-2485 |
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| creator | Daloglu, O. O. Unal, M. C. Kemaloglu, C. A. Bolatturk, O. F. Ozyazgan, I. Tanriverdi, F. Coruh, A. Kelestimur, F. |
| description | Purpose
This study was designed to assess the pituitary functions of patients with traumatic maxillofacial fractures and compare the results with healthy controls.
Methods
Thirty patients (mean age, 38.14 ± 14.15 years; twenty-six male, four female) with a traumatic maxillofacial fracture at least 12 months ago (mean 27.5 ± 6.5 months) and thirty healthy controls (mean age, 42.77 ± 11.36 years; twenty-five male, five female) were included. None of the patients were unconscious following head trauma, and none required hospitalization in intensive care. Basal pituitary hormone levels of the patients were evaluated. All patients and controls had a glucagon stimulation test and an ACTH stimulation test to evaluate the hypothalamic–pituitary–adrenal axis and the GH–IGF-1 axis.
Results
Five of thirty patients (16.6%) had isolated growth hormone (GH) deficiency based on a glucagon stimulation test (GST). The mean peak GH level after GST in patients with hypopituitarism (0.54 ng/ml) was significantly lower than those without hypopituitarism (7.01 ng/ml) and healthy controls (11.70 ng/ml) (
P
|
| doi_str_mv | 10.1007/s40618-024-02349-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2972704655</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2972704655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-af4345a15c50ce953eba0ff0ed4eaa024028dd35a80ddaa65ce9d105e5889ce73</originalsourceid><addsrcrecordid>eNp9kE1PHDEMhiME6i7QP9BDlSOXoZ7JZCdzRKulICFxKefIm3EgKDOz5KOFf0_K0ooTh8ix_fi1_DL2rYbzGqD7EVtY1aqCpi1PtH2lDtiy7hqolFCrww__BTuO8RFAdEJ1X9hCKAmi7-sl85vf6DMmN098tnznUnYJwwu3eTJvVZwGPlLC7eyd4TsMWDIKkbupZMnRlCL_49IDTwHzWCqGj_jsvJ8tGoee24Am5UDxlB1Z9JG-vscTdne5-bW-qm5uf16vL24qI9omVWhb0UqspZFgqJeCtgjWAg0tIZZzoVHDICQqGAbElSzQUIMkqVRvqBMn7GyvuwvzU6aY9OiiIe9xojlH3fRd00G7krKgzR41YY4xkNW74MZigK5B_3VZ713WZa1-c1mrMvT9XT9vRxr-j_yztQBiD8TSmu4p6Mc5h6nc_JnsK_GXi2I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2972704655</pqid></control><display><type>article</type><title>Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures</title><source>SpringerLink Journals - AutoHoldings</source><creator>Daloglu, O. O. ; Unal, M. C. ; Kemaloglu, C. A. ; Bolatturk, O. F. ; Ozyazgan, I. ; Tanriverdi, F. ; Coruh, A. ; Kelestimur, F.</creator><creatorcontrib>Daloglu, O. O. ; Unal, M. C. ; Kemaloglu, C. A. ; Bolatturk, O. F. ; Ozyazgan, I. ; Tanriverdi, F. ; Coruh, A. ; Kelestimur, F.</creatorcontrib><description>Purpose
This study was designed to assess the pituitary functions of patients with traumatic maxillofacial fractures and compare the results with healthy controls.
Methods
Thirty patients (mean age, 38.14 ± 14.15 years; twenty-six male, four female) with a traumatic maxillofacial fracture at least 12 months ago (mean 27.5 ± 6.5 months) and thirty healthy controls (mean age, 42.77 ± 11.36 years; twenty-five male, five female) were included. None of the patients were unconscious following head trauma, and none required hospitalization in intensive care. Basal pituitary hormone levels of the patients were evaluated. All patients and controls had a glucagon stimulation test and an ACTH stimulation test to evaluate the hypothalamic–pituitary–adrenal axis and the GH–IGF-1 axis.
Results
Five of thirty patients (16.6%) had isolated growth hormone (GH) deficiency based on a glucagon stimulation test (GST). The mean peak GH level after GST in patients with hypopituitarism (0.54 ng/ml) was significantly lower than those without hypopituitarism (7.01 ng/ml) and healthy controls (11.70 ng/ml) (
P
< 0.001). No anterior pituitary hormone deficiency was found in the patients, except for GH.
Conclusion
Our study is the first to evaluate the presence of hypopituitarism in patients with traumatic maxillofacial fractures. Preliminary findings suggest that hypopituitarism and GH deficiency pose significant risks to these patients, particularly during the chronic phase of their trauma. However, these findings need to be validated in larger scale prospective studies with more patients.</description><identifier>ISSN: 1720-8386</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-024-02349-8</identifier><identifier>PMID: 38503991</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Endocrinology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original Article</subject><ispartof>Journal of endocrinological investigation, 2024-10, Vol.47 (10), p.2477-2485</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c342t-af4345a15c50ce953eba0ff0ed4eaa024028dd35a80ddaa65ce9d105e5889ce73</cites><orcidid>0000-0003-3708-9371 ; 0000-0003-2074-4587 ; 0000-0002-7863-4084 ; 0000-0001-8325-2796 ; 0000-0001-8000-5220 ; 0000-0001-8277-6774</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-024-02349-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-024-02349-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38503991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daloglu, O. O.</creatorcontrib><creatorcontrib>Unal, M. C.</creatorcontrib><creatorcontrib>Kemaloglu, C. A.</creatorcontrib><creatorcontrib>Bolatturk, O. F.</creatorcontrib><creatorcontrib>Ozyazgan, I.</creatorcontrib><creatorcontrib>Tanriverdi, F.</creatorcontrib><creatorcontrib>Coruh, A.</creatorcontrib><creatorcontrib>Kelestimur, F.</creatorcontrib><title>Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose
This study was designed to assess the pituitary functions of patients with traumatic maxillofacial fractures and compare the results with healthy controls.
Methods
Thirty patients (mean age, 38.14 ± 14.15 years; twenty-six male, four female) with a traumatic maxillofacial fracture at least 12 months ago (mean 27.5 ± 6.5 months) and thirty healthy controls (mean age, 42.77 ± 11.36 years; twenty-five male, five female) were included. None of the patients were unconscious following head trauma, and none required hospitalization in intensive care. Basal pituitary hormone levels of the patients were evaluated. All patients and controls had a glucagon stimulation test and an ACTH stimulation test to evaluate the hypothalamic–pituitary–adrenal axis and the GH–IGF-1 axis.
Results
Five of thirty patients (16.6%) had isolated growth hormone (GH) deficiency based on a glucagon stimulation test (GST). The mean peak GH level after GST in patients with hypopituitarism (0.54 ng/ml) was significantly lower than those without hypopituitarism (7.01 ng/ml) and healthy controls (11.70 ng/ml) (
P
< 0.001). No anterior pituitary hormone deficiency was found in the patients, except for GH.
Conclusion
Our study is the first to evaluate the presence of hypopituitarism in patients with traumatic maxillofacial fractures. Preliminary findings suggest that hypopituitarism and GH deficiency pose significant risks to these patients, particularly during the chronic phase of their trauma. However, these findings need to be validated in larger scale prospective studies with more patients.</description><subject>Endocrinology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original Article</subject><issn>1720-8386</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kE1PHDEMhiME6i7QP9BDlSOXoZ7JZCdzRKulICFxKefIm3EgKDOz5KOFf0_K0ooTh8ix_fi1_DL2rYbzGqD7EVtY1aqCpi1PtH2lDtiy7hqolFCrww__BTuO8RFAdEJ1X9hCKAmi7-sl85vf6DMmN098tnznUnYJwwu3eTJvVZwGPlLC7eyd4TsMWDIKkbupZMnRlCL_49IDTwHzWCqGj_jsvJ8tGoee24Am5UDxlB1Z9JG-vscTdne5-bW-qm5uf16vL24qI9omVWhb0UqspZFgqJeCtgjWAg0tIZZzoVHDICQqGAbElSzQUIMkqVRvqBMn7GyvuwvzU6aY9OiiIe9xojlH3fRd00G7krKgzR41YY4xkNW74MZigK5B_3VZ713WZa1-c1mrMvT9XT9vRxr-j_yztQBiD8TSmu4p6Mc5h6nc_JnsK_GXi2I</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Daloglu, O. O.</creator><creator>Unal, M. C.</creator><creator>Kemaloglu, C. A.</creator><creator>Bolatturk, O. F.</creator><creator>Ozyazgan, I.</creator><creator>Tanriverdi, F.</creator><creator>Coruh, A.</creator><creator>Kelestimur, F.</creator><general>Springer International Publishing</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3708-9371</orcidid><orcidid>https://orcid.org/0000-0003-2074-4587</orcidid><orcidid>https://orcid.org/0000-0002-7863-4084</orcidid><orcidid>https://orcid.org/0000-0001-8325-2796</orcidid><orcidid>https://orcid.org/0000-0001-8000-5220</orcidid><orcidid>https://orcid.org/0000-0001-8277-6774</orcidid></search><sort><creationdate>20241001</creationdate><title>Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures</title><author>Daloglu, O. O. ; Unal, M. C. ; Kemaloglu, C. A. ; Bolatturk, O. F. ; Ozyazgan, I. ; Tanriverdi, F. ; Coruh, A. ; Kelestimur, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-af4345a15c50ce953eba0ff0ed4eaa024028dd35a80ddaa65ce9d105e5889ce73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Endocrinology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daloglu, O. O.</creatorcontrib><creatorcontrib>Unal, M. C.</creatorcontrib><creatorcontrib>Kemaloglu, C. A.</creatorcontrib><creatorcontrib>Bolatturk, O. F.</creatorcontrib><creatorcontrib>Ozyazgan, I.</creatorcontrib><creatorcontrib>Tanriverdi, F.</creatorcontrib><creatorcontrib>Coruh, A.</creatorcontrib><creatorcontrib>Kelestimur, F.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daloglu, O. O.</au><au>Unal, M. C.</au><au>Kemaloglu, C. A.</au><au>Bolatturk, O. F.</au><au>Ozyazgan, I.</au><au>Tanriverdi, F.</au><au>Coruh, A.</au><au>Kelestimur, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>47</volume><issue>10</issue><spage>2477</spage><epage>2485</epage><pages>2477-2485</pages><issn>1720-8386</issn><eissn>1720-8386</eissn><abstract>Purpose
This study was designed to assess the pituitary functions of patients with traumatic maxillofacial fractures and compare the results with healthy controls.
Methods
Thirty patients (mean age, 38.14 ± 14.15 years; twenty-six male, four female) with a traumatic maxillofacial fracture at least 12 months ago (mean 27.5 ± 6.5 months) and thirty healthy controls (mean age, 42.77 ± 11.36 years; twenty-five male, five female) were included. None of the patients were unconscious following head trauma, and none required hospitalization in intensive care. Basal pituitary hormone levels of the patients were evaluated. All patients and controls had a glucagon stimulation test and an ACTH stimulation test to evaluate the hypothalamic–pituitary–adrenal axis and the GH–IGF-1 axis.
Results
Five of thirty patients (16.6%) had isolated growth hormone (GH) deficiency based on a glucagon stimulation test (GST). The mean peak GH level after GST in patients with hypopituitarism (0.54 ng/ml) was significantly lower than those without hypopituitarism (7.01 ng/ml) and healthy controls (11.70 ng/ml) (
P
< 0.001). No anterior pituitary hormone deficiency was found in the patients, except for GH.
Conclusion
Our study is the first to evaluate the presence of hypopituitarism in patients with traumatic maxillofacial fractures. Preliminary findings suggest that hypopituitarism and GH deficiency pose significant risks to these patients, particularly during the chronic phase of their trauma. However, these findings need to be validated in larger scale prospective studies with more patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38503991</pmid><doi>10.1007/s40618-024-02349-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3708-9371</orcidid><orcidid>https://orcid.org/0000-0003-2074-4587</orcidid><orcidid>https://orcid.org/0000-0002-7863-4084</orcidid><orcidid>https://orcid.org/0000-0001-8325-2796</orcidid><orcidid>https://orcid.org/0000-0001-8000-5220</orcidid><orcidid>https://orcid.org/0000-0001-8277-6774</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures |
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