Abiotic Small Molecule Inhibitors and Activators of the LasR Quorum Sensing Receptor in Pseudomonas aeruginosa with Potencies Comparable or Surpassing N‑Acyl Homoserine Lactones

The opportunistic pathogen Pseudomonas aeruginosa controls almost 10% of its genome, including myriad virulence genes, via a cell-to-cell chemical communication system called quorum sensing (QS). Small molecules that either inhibit or activate QS in P. aeruginosa represent useful research tools to s...

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Veröffentlicht in:	ACS infectious diseases 2024-04, Vol.10 (4), p.1212-1221
Hauptverfasser:	Manson, Daniel E., Ananiev, Gene E., Guo, Song, Ericksen, Spencer S., Santa, Emma E., Blackwell, Helen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-Butyrolactones - chemistry Bacterial Proteins Pseudomonas aeruginosa - metabolism Quorum Sensing Signal Transduction
Online-Zugang:	Volltext
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