Dynamic ctDNA-based analysis of drug-resistant gene alterations at RAS/BRAF wild-type metastatic colorectal cancer patients after cetuximab plus chemotherapy as the first-line treatment

•This is a prospective clinical cohort study.•We tracked the dynamic changes of genes in mCRC patients who received cetuximab plus chemotherapy.•TP53 status AMER1 status and their co-mutation influenced drug resistance of involved patients. The purpose of this study was to explore the dynamic change...

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Veröffentlicht in:	International immunopharmacology 2024-04, Vol.131, p.111887-111887, Article 111887
Hauptverfasser:	Zhou, Yu-Wen, Zhao, Xin, Ni, Lu, Cao, Peng, Leng, Wei-Bing, Zhu, Qing, Gou, Hong-Feng, Zhang, Jiao, Li, Xiao-Fen, Qiu, Meng
Format:	Artikel
Sprache:	eng
Schlagworte:	Cetuximab ctDNA mCRC
Online-Zugang:	Volltext
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