Late preterm antenatal steroid use and infant outcomes in a single center
Objective To characterize late preterm antenatal steroids (AS) use and associated neonatal outcomes in a single academic center. Study design Retrospective study of 503 singleton, mother-infant dyads delivered between 34 0/7 and 36 6/7 weeks gestation between January 1, 2016 and December 31, 2020. R...
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| Veröffentlicht in: | Journal of perinatology 2024-07, Vol.44 (7), p.1009-1013 |
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| container_title | Journal of perinatology |
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| creator | Go, Mitzi Wahl, Madison Kruss, Tova McEvoy, Cindy T. |
| description | Objective
To characterize late preterm antenatal steroids (AS) use and associated neonatal outcomes in a single academic center.
Study design
Retrospective study of 503 singleton, mother-infant dyads delivered between 34 0/7 and 36 6/7 weeks gestation between January 1, 2016 and December 31, 2020.
Results
Forty-three percent did not receive AS (No AS) prior to delivery. Among AS treated, 50% were sub-optimal dosing. No AS had higher preterm premature rupture of membranes and maternal diabetes. AS group had lower mean gestational age, birthweight, longer time from admission to delivery and longer NICU stay. There was no difference in neonatal hypoglycemia.
Conclusions
Sub-optimal AS dosing in late preterms remains high in our center. AS did not improve neonatal outcomes. Studies are needed to evaluate the impact of AS in diabetics delivering late preterm, to optimize the timing of AS dosing, and evaluate the longer term impact on late preterm infants. |
| doi_str_mv | 10.1038/s41372-024-01934-2 |
| format | Article |
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To characterize late preterm antenatal steroids (AS) use and associated neonatal outcomes in a single academic center.
Study design
Retrospective study of 503 singleton, mother-infant dyads delivered between 34 0/7 and 36 6/7 weeks gestation between January 1, 2016 and December 31, 2020.
Results
Forty-three percent did not receive AS (No AS) prior to delivery. Among AS treated, 50% were sub-optimal dosing. No AS had higher preterm premature rupture of membranes and maternal diabetes. AS group had lower mean gestational age, birthweight, longer time from admission to delivery and longer NICU stay. There was no difference in neonatal hypoglycemia.
Conclusions
Sub-optimal AS dosing in late preterms remains high in our center. AS did not improve neonatal outcomes. Studies are needed to evaluate the impact of AS in diabetics delivering late preterm, to optimize the timing of AS dosing, and evaluate the longer term impact on late preterm infants.</description><identifier>ISSN: 0743-8346</identifier><identifier>ISSN: 1476-5543</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-024-01934-2</identifier><identifier>PMID: 38499754</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/700/1720 ; 692/700/565/2194 ; Birth weight ; Clinical outcomes ; Diabetes mellitus ; Dosage ; Gestational age ; Hypoglycemia ; Infants ; Medicine ; Medicine & Public Health ; Neonates ; Optimization ; Pediatric Surgery ; Pediatrics ; Pregnancy ; Premature babies ; Steroid hormones ; Steroids</subject><ispartof>Journal of perinatology, 2024-07, Vol.44 (7), p.1009-1013</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-279956f1ada646477a06c0eda59078594cabb9fa7f92bacc9bf4a170be90d2133</cites><orcidid>0000-0001-8501-8813 ; 0000-0001-7098-3223</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38499754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Go, Mitzi</creatorcontrib><creatorcontrib>Wahl, Madison</creatorcontrib><creatorcontrib>Kruss, Tova</creatorcontrib><creatorcontrib>McEvoy, Cindy T.</creatorcontrib><title>Late preterm antenatal steroid use and infant outcomes in a single center</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To characterize late preterm antenatal steroids (AS) use and associated neonatal outcomes in a single academic center.
Study design
Retrospective study of 503 singleton, mother-infant dyads delivered between 34 0/7 and 36 6/7 weeks gestation between January 1, 2016 and December 31, 2020.
Results
Forty-three percent did not receive AS (No AS) prior to delivery. Among AS treated, 50% were sub-optimal dosing. No AS had higher preterm premature rupture of membranes and maternal diabetes. AS group had lower mean gestational age, birthweight, longer time from admission to delivery and longer NICU stay. There was no difference in neonatal hypoglycemia.
Conclusions
Sub-optimal AS dosing in late preterms remains high in our center. AS did not improve neonatal outcomes. Studies are needed to evaluate the impact of AS in diabetics delivering late preterm, to optimize the timing of AS dosing, and evaluate the longer term impact on late preterm infants.</description><subject>692/700/1720</subject><subject>692/700/565/2194</subject><subject>Birth weight</subject><subject>Clinical outcomes</subject><subject>Diabetes mellitus</subject><subject>Dosage</subject><subject>Gestational age</subject><subject>Hypoglycemia</subject><subject>Infants</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Optimization</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Premature babies</subject><subject>Steroid hormones</subject><subject>Steroids</subject><issn>0743-8346</issn><issn>1476-5543</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAUhS0EoqXwBxiQJRYWg1-x4xFVPCpVYoHZcpybKlUexU4G_j0uKSAxMF3de75zbB2ELhm9ZVTkd1EyoTmhXBLKjJCEH6E5k1qRLJPiGM2ploLkQqoZOotxS-le1KdoJnJpjM7kHK3WbgC8CzBAaLHrBujc4Boc097XJR4jpGuJ665KIu7HwfctxLRjh2PdbRrAHpItnKOTyjURLg5zgd4eH16Xz2T98rRa3q-JF1wNhGtjMlUxVzolldTaUeUplC4zVOeZkd4VhamcrgwvnPemqKRjmhZgaMmZEAt0M-XuQv8-QhxsW0cPTeM66MdouVG54YzneUKv_6Dbfgxd-p0VVCtGM6r3gXyifOhjDFDZXahbFz4so3ZftJ2Ktqlo-1W05cl0dYgeixbKH8t3swkQExCT1G0g_L79T-wn4tWH_Q</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Go, Mitzi</creator><creator>Wahl, Madison</creator><creator>Kruss, Tova</creator><creator>McEvoy, Cindy T.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8501-8813</orcidid><orcidid>https://orcid.org/0000-0001-7098-3223</orcidid></search><sort><creationdate>20240701</creationdate><title>Late preterm antenatal steroid use and infant outcomes in a single center</title><author>Go, Mitzi ; Wahl, Madison ; Kruss, Tova ; McEvoy, Cindy T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-279956f1ada646477a06c0eda59078594cabb9fa7f92bacc9bf4a170be90d2133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>692/700/1720</topic><topic>692/700/565/2194</topic><topic>Birth weight</topic><topic>Clinical outcomes</topic><topic>Diabetes mellitus</topic><topic>Dosage</topic><topic>Gestational age</topic><topic>Hypoglycemia</topic><topic>Infants</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Optimization</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Premature babies</topic><topic>Steroid hormones</topic><topic>Steroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Go, Mitzi</creatorcontrib><creatorcontrib>Wahl, Madison</creatorcontrib><creatorcontrib>Kruss, Tova</creatorcontrib><creatorcontrib>McEvoy, Cindy T.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Go, Mitzi</au><au>Wahl, Madison</au><au>Kruss, Tova</au><au>McEvoy, Cindy T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Late preterm antenatal steroid use and infant outcomes in a single center</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>44</volume><issue>7</issue><spage>1009</spage><epage>1013</epage><pages>1009-1013</pages><issn>0743-8346</issn><issn>1476-5543</issn><eissn>1476-5543</eissn><abstract>Objective
To characterize late preterm antenatal steroids (AS) use and associated neonatal outcomes in a single academic center.
Study design
Retrospective study of 503 singleton, mother-infant dyads delivered between 34 0/7 and 36 6/7 weeks gestation between January 1, 2016 and December 31, 2020.
Results
Forty-three percent did not receive AS (No AS) prior to delivery. Among AS treated, 50% were sub-optimal dosing. No AS had higher preterm premature rupture of membranes and maternal diabetes. AS group had lower mean gestational age, birthweight, longer time from admission to delivery and longer NICU stay. There was no difference in neonatal hypoglycemia.
Conclusions
Sub-optimal AS dosing in late preterms remains high in our center. AS did not improve neonatal outcomes. Studies are needed to evaluate the impact of AS in diabetics delivering late preterm, to optimize the timing of AS dosing, and evaluate the longer term impact on late preterm infants.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>38499754</pmid><doi>10.1038/s41372-024-01934-2</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-8501-8813</orcidid><orcidid>https://orcid.org/0000-0001-7098-3223</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | 692/700/1720 692/700/565/2194 Birth weight Clinical outcomes Diabetes mellitus Dosage Gestational age Hypoglycemia Infants Medicine Medicine & Public Health Neonates Optimization Pediatric Surgery Pediatrics Pregnancy Premature babies Steroid hormones Steroids |
| title | Late preterm antenatal steroid use and infant outcomes in a single center |
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