Comprehensive elucidation of resting-state functional connectivity in anorexia nervosa by a multicenter cross-sectional study
Previous research on the changes in resting-state functional connectivity (rsFC) in anorexia nervosa (AN) has been limited by an insufficient sample size, which reduced the reliability of the results and made it difficult to set the whole brain as regions of interest (ROIs). We analyzed functional m...
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| Veröffentlicht in: | Psychological medicine 2024-07, Vol.54 (10), p.2347-2360 |
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| creator | Sudo, Yusuke Ota, Junko Takamura, Tsunehiko Kamashita, Rio Hamatani, Sayo Numata, Noriko Chhatkuli, Ritu Bhusal Yoshida, Tokiko Takahashi, Jumpei Kitagawa, Hitomi Matsumoto, Koji Masuda, Yoshitada Nakazato, Michiko Sato, Yasuhiro Hamamoto, Yumi Shoji, Tomotaka Muratsubaki, Tomohiko Sugiura, Motoaki Fukudo, Shin Kawabata, Michiko Sunada, Momo Noda, Tomomi Tose, Keima Isobe, Masanori Kodama, Naoki Kakeda, Shingo Takahashi, Masatoshi Takakura, Shu Gondo, Motoharu Yoshihara, Kazufumi Moriguchi, Yoshiya Shimizu, Eiji Sekiguchi, Atsushi Hirano, Yoshiyuki |
| description | Previous research on the changes in resting-state functional connectivity (rsFC) in anorexia nervosa (AN) has been limited by an insufficient sample size, which reduced the reliability of the results and made it difficult to set the whole brain as regions of interest (ROIs).
We analyzed functional magnetic resonance imaging data from 114 female AN patients and 135 healthy controls (HC) and obtained self-reported psychological scales, including eating disorder examination questionnaire 6.0. One hundred sixty-four cortical, subcortical, cerebellar, and network parcellation regions were considered as ROIs. We calculated the ROI-to-ROI rsFCs and performed group comparisons.
Compared to HC, AN patients showed 12 stronger rsFCs mainly in regions containing dorsolateral prefrontal cortex (DLPFC), and 33 weaker rsFCs primarily in regions containing cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between anterior cingulate cortex (ACC) and thalamus (
< 0.01, false discovery rate [FDR] correction). Comparisons between AN subtypes showed that there were stronger rsFCs between right lingual gyrus and right supracalcarine cortex and between left temporal occipital fusiform cortex and medial part of visual network in the restricting type compared to the binge/purging type (
< 0.01, FDR correction).
Stronger rsFCs in regions containing mainly DLPFC, and weaker rsFCs in regions containing primarily cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between ACC and thalamus, may represent categorical diagnostic markers discriminating AN patients from HC. |
| doi_str_mv | 10.1017/S0033291724000485 |
| format | Article |
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We analyzed functional magnetic resonance imaging data from 114 female AN patients and 135 healthy controls (HC) and obtained self-reported psychological scales, including eating disorder examination questionnaire 6.0. One hundred sixty-four cortical, subcortical, cerebellar, and network parcellation regions were considered as ROIs. We calculated the ROI-to-ROI rsFCs and performed group comparisons.
Compared to HC, AN patients showed 12 stronger rsFCs mainly in regions containing dorsolateral prefrontal cortex (DLPFC), and 33 weaker rsFCs primarily in regions containing cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between anterior cingulate cortex (ACC) and thalamus (
< 0.01, false discovery rate [FDR] correction). Comparisons between AN subtypes showed that there were stronger rsFCs between right lingual gyrus and right supracalcarine cortex and between left temporal occipital fusiform cortex and medial part of visual network in the restricting type compared to the binge/purging type (
< 0.01, FDR correction).
Stronger rsFCs in regions containing mainly DLPFC, and weaker rsFCs in regions containing primarily cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between ACC and thalamus, may represent categorical diagnostic markers discriminating AN patients from HC.</description><identifier>ISSN: 0033-2917</identifier><identifier>ISSN: 1469-8978</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291724000485</identifier><identifier>PMID: 38500410</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Anorexia ; Anorexia Nervosa - diagnostic imaging ; Anorexia Nervosa - physiopathology ; Brain ; Brain - diagnostic imaging ; Brain - physiopathology ; Brain mapping ; Brain Mapping - methods ; Case-Control Studies ; Cerebellum ; Cerebellum - diagnostic imaging ; Cerebellum - physiopathology ; Cognition & reasoning ; Connectome - methods ; Cortex ; Cortex (cingulate) ; Cross-Sectional Studies ; Datasets ; Eating disorders ; Female ; Functional connectivity ; Functional magnetic resonance imaging ; Gyrus Cinguli - diagnostic imaging ; Gyrus Cinguli - physiopathology ; Humans ; Magnetic Resonance Imaging ; Mental disorders ; Neural networks ; Neuroimaging ; Neurosciences ; Occipital lobe ; Prefrontal cortex ; Psychiatrists ; Purging ; Reliability ; Resting ; Subtypes ; Temporal lobe ; Temporal lobes ; Thalamus ; Tomography ; Young Adult</subject><ispartof>Psychological medicine, 2024-07, Vol.54 (10), p.2347-2360</ispartof><rights>Copyright © The Author(s), 2024. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c324t-485b6a49f4d8734f98d4a678532cc3c7dff0d1904972bb42de1a65f451803d363</cites><orcidid>0000-0002-7648-9370</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,12825,27901,27902,30976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38500410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sudo, Yusuke</creatorcontrib><creatorcontrib>Ota, Junko</creatorcontrib><creatorcontrib>Takamura, Tsunehiko</creatorcontrib><creatorcontrib>Kamashita, Rio</creatorcontrib><creatorcontrib>Hamatani, Sayo</creatorcontrib><creatorcontrib>Numata, Noriko</creatorcontrib><creatorcontrib>Chhatkuli, Ritu Bhusal</creatorcontrib><creatorcontrib>Yoshida, Tokiko</creatorcontrib><creatorcontrib>Takahashi, Jumpei</creatorcontrib><creatorcontrib>Kitagawa, Hitomi</creatorcontrib><creatorcontrib>Matsumoto, Koji</creatorcontrib><creatorcontrib>Masuda, Yoshitada</creatorcontrib><creatorcontrib>Nakazato, Michiko</creatorcontrib><creatorcontrib>Sato, Yasuhiro</creatorcontrib><creatorcontrib>Hamamoto, Yumi</creatorcontrib><creatorcontrib>Shoji, Tomotaka</creatorcontrib><creatorcontrib>Muratsubaki, Tomohiko</creatorcontrib><creatorcontrib>Sugiura, Motoaki</creatorcontrib><creatorcontrib>Fukudo, Shin</creatorcontrib><creatorcontrib>Kawabata, Michiko</creatorcontrib><creatorcontrib>Sunada, Momo</creatorcontrib><creatorcontrib>Noda, Tomomi</creatorcontrib><creatorcontrib>Tose, Keima</creatorcontrib><creatorcontrib>Isobe, Masanori</creatorcontrib><creatorcontrib>Kodama, Naoki</creatorcontrib><creatorcontrib>Kakeda, Shingo</creatorcontrib><creatorcontrib>Takahashi, Masatoshi</creatorcontrib><creatorcontrib>Takakura, Shu</creatorcontrib><creatorcontrib>Gondo, Motoharu</creatorcontrib><creatorcontrib>Yoshihara, Kazufumi</creatorcontrib><creatorcontrib>Moriguchi, Yoshiya</creatorcontrib><creatorcontrib>Shimizu, Eiji</creatorcontrib><creatorcontrib>Sekiguchi, Atsushi</creatorcontrib><creatorcontrib>Hirano, Yoshiyuki</creatorcontrib><title>Comprehensive elucidation of resting-state functional connectivity in anorexia nervosa by a multicenter cross-sectional study</title><title>Psychological medicine</title><addtitle>Psychol Med</addtitle><description>Previous research on the changes in resting-state functional connectivity (rsFC) in anorexia nervosa (AN) has been limited by an insufficient sample size, which reduced the reliability of the results and made it difficult to set the whole brain as regions of interest (ROIs).
We analyzed functional magnetic resonance imaging data from 114 female AN patients and 135 healthy controls (HC) and obtained self-reported psychological scales, including eating disorder examination questionnaire 6.0. One hundred sixty-four cortical, subcortical, cerebellar, and network parcellation regions were considered as ROIs. We calculated the ROI-to-ROI rsFCs and performed group comparisons.
Compared to HC, AN patients showed 12 stronger rsFCs mainly in regions containing dorsolateral prefrontal cortex (DLPFC), and 33 weaker rsFCs primarily in regions containing cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between anterior cingulate cortex (ACC) and thalamus (
< 0.01, false discovery rate [FDR] correction). Comparisons between AN subtypes showed that there were stronger rsFCs between right lingual gyrus and right supracalcarine cortex and between left temporal occipital fusiform cortex and medial part of visual network in the restricting type compared to the binge/purging type (
< 0.01, FDR correction).
Stronger rsFCs in regions containing mainly DLPFC, and weaker rsFCs in regions containing primarily cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between ACC and thalamus, may represent categorical diagnostic markers discriminating AN patients from HC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anorexia</subject><subject>Anorexia Nervosa - diagnostic imaging</subject><subject>Anorexia Nervosa - physiopathology</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Brain mapping</subject><subject>Brain Mapping - methods</subject><subject>Case-Control Studies</subject><subject>Cerebellum</subject><subject>Cerebellum - diagnostic imaging</subject><subject>Cerebellum - physiopathology</subject><subject>Cognition & reasoning</subject><subject>Connectome - methods</subject><subject>Cortex</subject><subject>Cortex (cingulate)</subject><subject>Cross-Sectional Studies</subject><subject>Datasets</subject><subject>Eating disorders</subject><subject>Female</subject><subject>Functional connectivity</subject><subject>Functional magnetic resonance imaging</subject><subject>Gyrus Cinguli - diagnostic imaging</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Mental disorders</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Occipital lobe</subject><subject>Prefrontal cortex</subject><subject>Psychiatrists</subject><subject>Purging</subject><subject>Reliability</subject><subject>Resting</subject><subject>Subtypes</subject><subject>Temporal lobe</subject><subject>Temporal lobes</subject><subject>Thalamus</subject><subject>Tomography</subject><subject>Young Adult</subject><issn>0033-2917</issn><issn>1469-8978</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNplkUtv1TAQhS1ERS-FH8AGWWLDJnT8SGIv0VV5SJVYFNaRY4_BVWJfbOeKu-C_N6EtC1iNRuebozk6hLxi8I4B6y9vAITgmvVcAoBU7ROyY7LTjdK9ekp2m9xs-jl5XsotABNM8mfkXKh25RnsyO99mg8Zf2As4YgUp8UGZ2pIkSZPM5Ya4vemVFOR-iXaTTETtSlGXJdjqCcaIjUxZfwVDI2Yj6kYOp6oofMy1WAxVszU5lRKU_DRodTFnV6QM2-mgi8f5gX59uHq6_5Tc_3l4-f9--vGCi5rsyYbOyO1l071QnqtnDRdr1rBrRW2d96DYxqk7vk4Su6Qma71smUKhBOduCBv730POf1c1lDDHIrFaTIR01IGrjulOXAGK_rmH_Q2LXn9uAyCcSl4B91GsXvqT6yMfjjkMJt8GhgMWzfDf92sN68fnJdxRvf34rEMcQc3QYsX</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Sudo, Yusuke</creator><creator>Ota, Junko</creator><creator>Takamura, 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elucidation of resting-state functional connectivity in anorexia nervosa by a multicenter cross-sectional study</title><author>Sudo, Yusuke ; Ota, Junko ; Takamura, Tsunehiko ; Kamashita, Rio ; Hamatani, Sayo ; Numata, Noriko ; Chhatkuli, Ritu Bhusal ; Yoshida, Tokiko ; Takahashi, Jumpei ; Kitagawa, Hitomi ; Matsumoto, Koji ; Masuda, Yoshitada ; Nakazato, Michiko ; Sato, Yasuhiro ; Hamamoto, Yumi ; Shoji, Tomotaka ; Muratsubaki, Tomohiko ; Sugiura, Motoaki ; Fukudo, Shin ; Kawabata, Michiko ; Sunada, Momo ; Noda, Tomomi ; Tose, Keima ; Isobe, Masanori ; Kodama, Naoki ; Kakeda, Shingo ; Takahashi, Masatoshi ; Takakura, Shu ; Gondo, Motoharu ; Yoshihara, Kazufumi ; Moriguchi, Yoshiya ; Shimizu, Eiji ; Sekiguchi, Atsushi ; Hirano, 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College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychological medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sudo, Yusuke</au><au>Ota, Junko</au><au>Takamura, Tsunehiko</au><au>Kamashita, Rio</au><au>Hamatani, Sayo</au><au>Numata, Noriko</au><au>Chhatkuli, Ritu Bhusal</au><au>Yoshida, Tokiko</au><au>Takahashi, Jumpei</au><au>Kitagawa, Hitomi</au><au>Matsumoto, Koji</au><au>Masuda, Yoshitada</au><au>Nakazato, Michiko</au><au>Sato, Yasuhiro</au><au>Hamamoto, Yumi</au><au>Shoji, Tomotaka</au><au>Muratsubaki, Tomohiko</au><au>Sugiura, Motoaki</au><au>Fukudo, Shin</au><au>Kawabata, Michiko</au><au>Sunada, Momo</au><au>Noda, Tomomi</au><au>Tose, Keima</au><au>Isobe, Masanori</au><au>Kodama, Naoki</au><au>Kakeda, Shingo</au><au>Takahashi, Masatoshi</au><au>Takakura, Shu</au><au>Gondo, Motoharu</au><au>Yoshihara, Kazufumi</au><au>Moriguchi, Yoshiya</au><au>Shimizu, Eiji</au><au>Sekiguchi, Atsushi</au><au>Hirano, Yoshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive elucidation of resting-state functional connectivity in anorexia nervosa by a multicenter cross-sectional study</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol Med</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>54</volume><issue>10</issue><spage>2347</spage><epage>2360</epage><pages>2347-2360</pages><issn>0033-2917</issn><issn>1469-8978</issn><eissn>1469-8978</eissn><abstract>Previous research on the changes in resting-state functional connectivity (rsFC) in anorexia nervosa (AN) has been limited by an insufficient sample size, which reduced the reliability of the results and made it difficult to set the whole brain as regions of interest (ROIs).
We analyzed functional magnetic resonance imaging data from 114 female AN patients and 135 healthy controls (HC) and obtained self-reported psychological scales, including eating disorder examination questionnaire 6.0. One hundred sixty-four cortical, subcortical, cerebellar, and network parcellation regions were considered as ROIs. We calculated the ROI-to-ROI rsFCs and performed group comparisons.
Compared to HC, AN patients showed 12 stronger rsFCs mainly in regions containing dorsolateral prefrontal cortex (DLPFC), and 33 weaker rsFCs primarily in regions containing cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between anterior cingulate cortex (ACC) and thalamus (
< 0.01, false discovery rate [FDR] correction). Comparisons between AN subtypes showed that there were stronger rsFCs between right lingual gyrus and right supracalcarine cortex and between left temporal occipital fusiform cortex and medial part of visual network in the restricting type compared to the binge/purging type (
< 0.01, FDR correction).
Stronger rsFCs in regions containing mainly DLPFC, and weaker rsFCs in regions containing primarily cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between ACC and thalamus, may represent categorical diagnostic markers discriminating AN patients from HC.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>38500410</pmid><doi>10.1017/S0033291724000485</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-7648-9370</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-2917 |
| ispartof | Psychological medicine, 2024-07, Vol.54 (10), p.2347-2360 |
| issn | 0033-2917 1469-8978 1469-8978 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2968920210 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Cambridge University Press Journals Complete |
| subjects | Adolescent Adult Anorexia Anorexia Nervosa - diagnostic imaging Anorexia Nervosa - physiopathology Brain Brain - diagnostic imaging Brain - physiopathology Brain mapping Brain Mapping - methods Case-Control Studies Cerebellum Cerebellum - diagnostic imaging Cerebellum - physiopathology Cognition & reasoning Connectome - methods Cortex Cortex (cingulate) Cross-Sectional Studies Datasets Eating disorders Female Functional connectivity Functional magnetic resonance imaging Gyrus Cinguli - diagnostic imaging Gyrus Cinguli - physiopathology Humans Magnetic Resonance Imaging Mental disorders Neural networks Neuroimaging Neurosciences Occipital lobe Prefrontal cortex Psychiatrists Purging Reliability Resting Subtypes Temporal lobe Temporal lobes Thalamus Tomography Young Adult |
| title | Comprehensive elucidation of resting-state functional connectivity in anorexia nervosa by a multicenter cross-sectional study |
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