Rate of occult metastasis in lip squamous cell carcinoma: A systematic review and meta‐analysis
Objectives The rate of occult metastasis in lip cancer is poorly studied. Management of the regional nodal basin in lip cancer is thus controversial. This study sought to understand the true rate of micrometastasis in lip cancer. Materials and Methods Systematic review and meta‐analysis was conducte...
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| Veröffentlicht in: | Head & neck 2024-10, Vol.46 (10), p.2517-2523 |
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| creator | Kansara, Sagar Oral, Evrim Sarkar, Indrani Sandulache, Vlad Mualla, Rula Walvekar, Rohan R. Ryan, William Ha, Patrick |
| description | Objectives
The rate of occult metastasis in lip cancer is poorly studied. Management of the regional nodal basin in lip cancer is thus controversial. This study sought to understand the true rate of micrometastasis in lip cancer.
Materials and Methods
Systematic review and meta‐analysis was conducted of English language studies reporting lip cancer sentinel node biopsy results. Studies were obtained from the PubMed database between the years 2000 and 2023 using the search terms “sentinel node biopsy” and “squamous cell carcinoma.” Random effect and fixed effect meta‐analyses were performed.
Results
Thirteen studies met inclusion criteria. Low heterogeneity was noted among the studies, as indicated by the I2 inconsistency test (I2 = 0%). The rate of occult metastasis ranged between 0 and 33% (mean 9%). A total of 189 lip sentinel node biopsies had been performed. Of these, 21 revealed occult nodal metastasis (11.1%, 95% CI 7.36%–16.44%). One step, generalized linear mixed modeling revealed the true rate of occult nodal metastasis to be 10% (95% CI (0.0504, 0.1746), p |
| doi_str_mv | 10.1002/hed.27747 |
| format | Article |
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The rate of occult metastasis in lip cancer is poorly studied. Management of the regional nodal basin in lip cancer is thus controversial. This study sought to understand the true rate of micrometastasis in lip cancer.
Materials and Methods
Systematic review and meta‐analysis was conducted of English language studies reporting lip cancer sentinel node biopsy results. Studies were obtained from the PubMed database between the years 2000 and 2023 using the search terms “sentinel node biopsy” and “squamous cell carcinoma.” Random effect and fixed effect meta‐analyses were performed.
Results
Thirteen studies met inclusion criteria. Low heterogeneity was noted among the studies, as indicated by the I2 inconsistency test (I2 = 0%). The rate of occult metastasis ranged between 0 and 33% (mean 9%). A total of 189 lip sentinel node biopsies had been performed. Of these, 21 revealed occult nodal metastasis (11.1%, 95% CI 7.36%–16.44%). One step, generalized linear mixed modeling revealed the true rate of occult nodal metastasis to be 10% (95% CI (0.0504, 0.1746), p < 0.0001).
Conclusion
The rate of occult metastasis in lip cancer approaches the threshold for elective management of the regional nodal basin. Sentinel node biopsy is optimally suited for management of high‐risk early T stage lip cancer.</description><identifier>ISSN: 1043-3074</identifier><identifier>ISSN: 1097-0347</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27747</identifier><identifier>PMID: 38497534</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Biopsy ; Cancer ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - therapy ; Disease management ; Head & neck cancer ; head and neck cancer ; Humans ; Lip ; lip cancer ; Lip Neoplasms - pathology ; Lymphatic Metastasis ; Meta-analysis ; Metastases ; Metastasis ; Neoplasm Micrometastasis - pathology ; occult metastasis ; Sentinel Lymph Node Biopsy ; sentinel node biopsy ; Squamous cell carcinoma ; Systematic review</subject><ispartof>Head & neck, 2024-10, Vol.46 (10), p.2517-2523</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3137-796a7c84a15960c5f839e56146ad70b293777c953f7980b69ec186937017f23</cites><orcidid>0000-0002-9205-385X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.27747$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.27747$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38497534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kansara, Sagar</creatorcontrib><creatorcontrib>Oral, Evrim</creatorcontrib><creatorcontrib>Sarkar, Indrani</creatorcontrib><creatorcontrib>Sandulache, Vlad</creatorcontrib><creatorcontrib>Mualla, Rula</creatorcontrib><creatorcontrib>Walvekar, Rohan R.</creatorcontrib><creatorcontrib>Ryan, William</creatorcontrib><creatorcontrib>Ha, Patrick</creatorcontrib><title>Rate of occult metastasis in lip squamous cell carcinoma: A systematic review and meta‐analysis</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Objectives
The rate of occult metastasis in lip cancer is poorly studied. Management of the regional nodal basin in lip cancer is thus controversial. This study sought to understand the true rate of micrometastasis in lip cancer.
Materials and Methods
Systematic review and meta‐analysis was conducted of English language studies reporting lip cancer sentinel node biopsy results. Studies were obtained from the PubMed database between the years 2000 and 2023 using the search terms “sentinel node biopsy” and “squamous cell carcinoma.” Random effect and fixed effect meta‐analyses were performed.
Results
Thirteen studies met inclusion criteria. Low heterogeneity was noted among the studies, as indicated by the I2 inconsistency test (I2 = 0%). The rate of occult metastasis ranged between 0 and 33% (mean 9%). A total of 189 lip sentinel node biopsies had been performed. Of these, 21 revealed occult nodal metastasis (11.1%, 95% CI 7.36%–16.44%). One step, generalized linear mixed modeling revealed the true rate of occult nodal metastasis to be 10% (95% CI (0.0504, 0.1746), p < 0.0001).
Conclusion
The rate of occult metastasis in lip cancer approaches the threshold for elective management of the regional nodal basin. Sentinel node biopsy is optimally suited for management of high‐risk early T stage lip cancer.</description><subject>Biopsy</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Disease management</subject><subject>Head & neck cancer</subject><subject>head and neck cancer</subject><subject>Humans</subject><subject>Lip</subject><subject>lip cancer</subject><subject>Lip Neoplasms - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Meta-analysis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Neoplasm Micrometastasis - pathology</subject><subject>occult metastasis</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>sentinel node biopsy</subject><subject>Squamous cell carcinoma</subject><subject>Systematic review</subject><issn>1043-3074</issn><issn>1097-0347</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMotlYXvoAE3Ohi2mSSyZm4K7VaoSCo-5CmGUyZSzuZsXTnI_iMPonpxY0gHDiHw8fHz4_QJSV9Skg8eLfzfgzA4Qh1KZEQEcbheHtzFjECvIPOvF8QQpjg8SnqsJRLSBjvIv2iG4urDFfGtHmDC9toH8Z57EqcuyX2q1YXVeuxsXmOja6NK6tC3-Eh9hvf2EI3zuDafji7xrqc7xTfn1-61PkmeM7RSaZzby8Ou4deH8Zvo0k0fX58Gg2nkWGUQQRSaDAp1zSRgpgkS5m0iaBc6DmQWSwZABiZsAxkSmZCWkNTEb6EQhazHrrZW5d1tWqtb1Th_DaxLm0Ir2IpgAi6raCHrv-gi6qtQ1qvGI0lJUkCLFC3e8rUlfe1zdSydoWuN4oStW1dhdbVrvXAXh2M7awI31_yt-YADPbA2uV2879JTcb3e-UP9O2Kxg</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Kansara, Sagar</creator><creator>Oral, Evrim</creator><creator>Sarkar, Indrani</creator><creator>Sandulache, Vlad</creator><creator>Mualla, Rula</creator><creator>Walvekar, Rohan R.</creator><creator>Ryan, William</creator><creator>Ha, Patrick</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9205-385X</orcidid></search><sort><creationdate>202410</creationdate><title>Rate of occult metastasis in lip squamous cell carcinoma: A systematic review and meta‐analysis</title><author>Kansara, Sagar ; Oral, Evrim ; Sarkar, Indrani ; Sandulache, Vlad ; Mualla, Rula ; Walvekar, Rohan R. ; Ryan, William ; Ha, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3137-796a7c84a15960c5f839e56146ad70b293777c953f7980b69ec186937017f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biopsy</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Disease management</topic><topic>Head & neck cancer</topic><topic>head and neck cancer</topic><topic>Humans</topic><topic>Lip</topic><topic>lip cancer</topic><topic>Lip Neoplasms - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Meta-analysis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Neoplasm Micrometastasis - pathology</topic><topic>occult metastasis</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>sentinel node biopsy</topic><topic>Squamous cell carcinoma</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kansara, Sagar</creatorcontrib><creatorcontrib>Oral, Evrim</creatorcontrib><creatorcontrib>Sarkar, Indrani</creatorcontrib><creatorcontrib>Sandulache, Vlad</creatorcontrib><creatorcontrib>Mualla, Rula</creatorcontrib><creatorcontrib>Walvekar, Rohan R.</creatorcontrib><creatorcontrib>Ryan, William</creatorcontrib><creatorcontrib>Ha, Patrick</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kansara, Sagar</au><au>Oral, Evrim</au><au>Sarkar, Indrani</au><au>Sandulache, Vlad</au><au>Mualla, Rula</au><au>Walvekar, Rohan R.</au><au>Ryan, William</au><au>Ha, Patrick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rate of occult metastasis in lip squamous cell carcinoma: A systematic review and meta‐analysis</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2024-10</date><risdate>2024</risdate><volume>46</volume><issue>10</issue><spage>2517</spage><epage>2523</epage><pages>2517-2523</pages><issn>1043-3074</issn><issn>1097-0347</issn><eissn>1097-0347</eissn><abstract>Objectives
The rate of occult metastasis in lip cancer is poorly studied. Management of the regional nodal basin in lip cancer is thus controversial. This study sought to understand the true rate of micrometastasis in lip cancer.
Materials and Methods
Systematic review and meta‐analysis was conducted of English language studies reporting lip cancer sentinel node biopsy results. Studies were obtained from the PubMed database between the years 2000 and 2023 using the search terms “sentinel node biopsy” and “squamous cell carcinoma.” Random effect and fixed effect meta‐analyses were performed.
Results
Thirteen studies met inclusion criteria. Low heterogeneity was noted among the studies, as indicated by the I2 inconsistency test (I2 = 0%). The rate of occult metastasis ranged between 0 and 33% (mean 9%). A total of 189 lip sentinel node biopsies had been performed. Of these, 21 revealed occult nodal metastasis (11.1%, 95% CI 7.36%–16.44%). One step, generalized linear mixed modeling revealed the true rate of occult nodal metastasis to be 10% (95% CI (0.0504, 0.1746), p < 0.0001).
Conclusion
The rate of occult metastasis in lip cancer approaches the threshold for elective management of the regional nodal basin. Sentinel node biopsy is optimally suited for management of high‐risk early T stage lip cancer.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38497534</pmid><doi>10.1002/hed.27747</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9205-385X</orcidid></addata></record> |
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| subjects | Biopsy Cancer Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - therapy Disease management Head & neck cancer head and neck cancer Humans Lip lip cancer Lip Neoplasms - pathology Lymphatic Metastasis Meta-analysis Metastases Metastasis Neoplasm Micrometastasis - pathology occult metastasis Sentinel Lymph Node Biopsy sentinel node biopsy Squamous cell carcinoma Systematic review |
| title | Rate of occult metastasis in lip squamous cell carcinoma: A systematic review and meta‐analysis |
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