Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation
Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT), and stratification of the high-risk group before transplantation is significant. Serum autotaxin (ATX) levels have been reported to incr...
Gespeichert in:
| Veröffentlicht in: | Annals of hematology 2024-05, Vol.103 (5), p.1705-1715 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1715 |
|---|---|
| container_issue | 5 |
| container_start_page | 1705 |
| container_title | Annals of hematology |
| container_volume | 103 |
| creator | Takemura, Kazuya Nakamae, Mika Okamura, Hiroshi Sakatoku, Kazuki Ido, Kentaro Makuuchi, Yosuke Kuno, Masatomo Takakuwa, Teruhito Hirose, Asao Nishimoto, Mitsutaka Nakashima, Yasuhiro Koh, Hideo Igarashi, Koji Kubota, Hiroshi Hino, Masayuki Nakamae, Hirohisa |
| description | Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT), and stratification of the high-risk group before transplantation is significant. Serum autotaxin (ATX) levels have been reported to increase in patients with liver fibrosis caused by metabolic inhibition from liver sinusoidal endothelial cells. Considering that the pathophysiology of VOD/SOS begins with liver sinusoidal endothelial cell injury, an increase in serum ATX levels may precede the onset of VOD/SOS. A retrospective study with 252 patients, including 12 patients with VOD/SOS, who had received allo-HCT was performed. The cumulative incidence of VOD/SOS was higher in the group with serum ATX levels before conditioning (baseline ATX) above the upper reference limit (high ATX group,
p
|
| doi_str_mv | 10.1007/s00277-024-05685-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2967058766</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2967058766</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-a037f8985d1776b8d1f65e6a74efcd742fa8034303d899ad80ccd04f8ccc8cd03</originalsourceid><addsrcrecordid>eNp9kcFuFSEUhonR2Gv1BVwYEjduxjLADMyyadSaNHGja8KFQ0tlYATmpn0nH1Kmt2riQjZwwsfHyfkRet2T9z0h4qwQQoXoCOUdGUY5dOQJ2vWc0VZK_hTtyMSmbmjrBL0o5ZaQnkpOn6MTJvnEh4Hu0M_ztaaq73zEvmCNl1QhVq8DXjJYb6o_AJ51_g4Zu5RxvQFs4QAhLXMDcXL4ADF1yZiwlg22voAucFZ8XEvytqnSvtS8NleKuNxHm9MMWLvanDqEdA0RvME3MOualuShtspACLhmHcsSdKx6e_wSPXM6FHj1uJ-ibx8_fL247K6-fPp8cX7VGUbH2mnChJOTHGwvxLiXtnfjAKMWHJyxglOnJWGcEWblNGkriTGWcCeNMbKd2Cl6d_QuOf1YoVQ1-7I1pCOktSg6jaKNWIxjQ9_-g96mNcfWnWr-jaBsahQ9UianUjI4tWTfpnqveqK2LNUxS9WyVA9Zqq2LN4_qdT-D_fPkd3gNYEegtKt4Dfnv3__R_gL90q-S</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3037663239</pqid></control><display><type>article</type><title>Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation</title><source>SpringerLink Journals</source><creator>Takemura, Kazuya ; Nakamae, Mika ; Okamura, Hiroshi ; Sakatoku, Kazuki ; Ido, Kentaro ; Makuuchi, Yosuke ; Kuno, Masatomo ; Takakuwa, Teruhito ; Hirose, Asao ; Nishimoto, Mitsutaka ; Nakashima, Yasuhiro ; Koh, Hideo ; Igarashi, Koji ; Kubota, Hiroshi ; Hino, Masayuki ; Nakamae, Hirohisa</creator><creatorcontrib>Takemura, Kazuya ; Nakamae, Mika ; Okamura, Hiroshi ; Sakatoku, Kazuki ; Ido, Kentaro ; Makuuchi, Yosuke ; Kuno, Masatomo ; Takakuwa, Teruhito ; Hirose, Asao ; Nishimoto, Mitsutaka ; Nakashima, Yasuhiro ; Koh, Hideo ; Igarashi, Koji ; Kubota, Hiroshi ; Hino, Masayuki ; Nakamae, Hirohisa</creatorcontrib><description>Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT), and stratification of the high-risk group before transplantation is significant. Serum autotaxin (ATX) levels have been reported to increase in patients with liver fibrosis caused by metabolic inhibition from liver sinusoidal endothelial cells. Considering that the pathophysiology of VOD/SOS begins with liver sinusoidal endothelial cell injury, an increase in serum ATX levels may precede the onset of VOD/SOS. A retrospective study with 252 patients, including 12 patients with VOD/SOS, who had received allo-HCT was performed. The cumulative incidence of VOD/SOS was higher in the group with serum ATX levels before conditioning (baseline ATX) above the upper reference limit (high ATX group,
p
< 0.001), and 1-year cumulative incidences were 22.7% (95% confidence interval [95%CI], 3.1–42.4%) and 3.5% (95%CI, 1.1–5.8%), respectively. In the multivariate analysis, elevated baseline ATX was identified as an independent risk factor for VOD/SOS development and showed an additive effect on the predictive ability of known risk factors. Furthermore, the incidence of VOD/SOS-related mortality was greater in the high ATX group (16.7% vs. 1.3%;
p
= 0.005). Serum ATX is a potential predictive marker for the development of VOD/SOS.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-024-05685-0</identifier><identifier>PMID: 38494552</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Hematology ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Stem cell transplantation</subject><ispartof>Annals of hematology, 2024-05, Vol.103 (5), p.1705-1715</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-a037f8985d1776b8d1f65e6a74efcd742fa8034303d899ad80ccd04f8ccc8cd03</cites><orcidid>0000-0002-9200-4804</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-024-05685-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-024-05685-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38494552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takemura, Kazuya</creatorcontrib><creatorcontrib>Nakamae, Mika</creatorcontrib><creatorcontrib>Okamura, Hiroshi</creatorcontrib><creatorcontrib>Sakatoku, Kazuki</creatorcontrib><creatorcontrib>Ido, Kentaro</creatorcontrib><creatorcontrib>Makuuchi, Yosuke</creatorcontrib><creatorcontrib>Kuno, Masatomo</creatorcontrib><creatorcontrib>Takakuwa, Teruhito</creatorcontrib><creatorcontrib>Hirose, Asao</creatorcontrib><creatorcontrib>Nishimoto, Mitsutaka</creatorcontrib><creatorcontrib>Nakashima, Yasuhiro</creatorcontrib><creatorcontrib>Koh, Hideo</creatorcontrib><creatorcontrib>Igarashi, Koji</creatorcontrib><creatorcontrib>Kubota, Hiroshi</creatorcontrib><creatorcontrib>Hino, Masayuki</creatorcontrib><creatorcontrib>Nakamae, Hirohisa</creatorcontrib><title>Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT), and stratification of the high-risk group before transplantation is significant. Serum autotaxin (ATX) levels have been reported to increase in patients with liver fibrosis caused by metabolic inhibition from liver sinusoidal endothelial cells. Considering that the pathophysiology of VOD/SOS begins with liver sinusoidal endothelial cell injury, an increase in serum ATX levels may precede the onset of VOD/SOS. A retrospective study with 252 patients, including 12 patients with VOD/SOS, who had received allo-HCT was performed. The cumulative incidence of VOD/SOS was higher in the group with serum ATX levels before conditioning (baseline ATX) above the upper reference limit (high ATX group,
p
< 0.001), and 1-year cumulative incidences were 22.7% (95% confidence interval [95%CI], 3.1–42.4%) and 3.5% (95%CI, 1.1–5.8%), respectively. In the multivariate analysis, elevated baseline ATX was identified as an independent risk factor for VOD/SOS development and showed an additive effect on the predictive ability of known risk factors. Furthermore, the incidence of VOD/SOS-related mortality was greater in the high ATX group (16.7% vs. 1.3%;
p
= 0.005). Serum ATX is a potential predictive marker for the development of VOD/SOS.</description><subject>Hematology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Stem cell transplantation</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kcFuFSEUhonR2Gv1BVwYEjduxjLADMyyadSaNHGja8KFQ0tlYATmpn0nH1Kmt2riQjZwwsfHyfkRet2T9z0h4qwQQoXoCOUdGUY5dOQJ2vWc0VZK_hTtyMSmbmjrBL0o5ZaQnkpOn6MTJvnEh4Hu0M_ztaaq73zEvmCNl1QhVq8DXjJYb6o_AJ51_g4Zu5RxvQFs4QAhLXMDcXL4ADF1yZiwlg22voAucFZ8XEvytqnSvtS8NleKuNxHm9MMWLvanDqEdA0RvME3MOualuShtspACLhmHcsSdKx6e_wSPXM6FHj1uJ-ibx8_fL247K6-fPp8cX7VGUbH2mnChJOTHGwvxLiXtnfjAKMWHJyxglOnJWGcEWblNGkriTGWcCeNMbKd2Cl6d_QuOf1YoVQ1-7I1pCOktSg6jaKNWIxjQ9_-g96mNcfWnWr-jaBsahQ9UianUjI4tWTfpnqveqK2LNUxS9WyVA9Zqq2LN4_qdT-D_fPkd3gNYEegtKt4Dfnv3__R_gL90q-S</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Takemura, Kazuya</creator><creator>Nakamae, Mika</creator><creator>Okamura, Hiroshi</creator><creator>Sakatoku, Kazuki</creator><creator>Ido, Kentaro</creator><creator>Makuuchi, Yosuke</creator><creator>Kuno, Masatomo</creator><creator>Takakuwa, Teruhito</creator><creator>Hirose, Asao</creator><creator>Nishimoto, Mitsutaka</creator><creator>Nakashima, Yasuhiro</creator><creator>Koh, Hideo</creator><creator>Igarashi, Koji</creator><creator>Kubota, Hiroshi</creator><creator>Hino, Masayuki</creator><creator>Nakamae, Hirohisa</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9200-4804</orcidid></search><sort><creationdate>20240501</creationdate><title>Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation</title><author>Takemura, Kazuya ; Nakamae, Mika ; Okamura, Hiroshi ; Sakatoku, Kazuki ; Ido, Kentaro ; Makuuchi, Yosuke ; Kuno, Masatomo ; Takakuwa, Teruhito ; Hirose, Asao ; Nishimoto, Mitsutaka ; Nakashima, Yasuhiro ; Koh, Hideo ; Igarashi, Koji ; Kubota, Hiroshi ; Hino, Masayuki ; Nakamae, Hirohisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-a037f8985d1776b8d1f65e6a74efcd742fa8034303d899ad80ccd04f8ccc8cd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Hematology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Stem cell transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takemura, Kazuya</creatorcontrib><creatorcontrib>Nakamae, Mika</creatorcontrib><creatorcontrib>Okamura, Hiroshi</creatorcontrib><creatorcontrib>Sakatoku, Kazuki</creatorcontrib><creatorcontrib>Ido, Kentaro</creatorcontrib><creatorcontrib>Makuuchi, Yosuke</creatorcontrib><creatorcontrib>Kuno, Masatomo</creatorcontrib><creatorcontrib>Takakuwa, Teruhito</creatorcontrib><creatorcontrib>Hirose, Asao</creatorcontrib><creatorcontrib>Nishimoto, Mitsutaka</creatorcontrib><creatorcontrib>Nakashima, Yasuhiro</creatorcontrib><creatorcontrib>Koh, Hideo</creatorcontrib><creatorcontrib>Igarashi, Koji</creatorcontrib><creatorcontrib>Kubota, Hiroshi</creatorcontrib><creatorcontrib>Hino, Masayuki</creatorcontrib><creatorcontrib>Nakamae, Hirohisa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takemura, Kazuya</au><au>Nakamae, Mika</au><au>Okamura, Hiroshi</au><au>Sakatoku, Kazuki</au><au>Ido, Kentaro</au><au>Makuuchi, Yosuke</au><au>Kuno, Masatomo</au><au>Takakuwa, Teruhito</au><au>Hirose, Asao</au><au>Nishimoto, Mitsutaka</au><au>Nakashima, Yasuhiro</au><au>Koh, Hideo</au><au>Igarashi, Koji</au><au>Kubota, Hiroshi</au><au>Hino, Masayuki</au><au>Nakamae, Hirohisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><addtitle>Ann Hematol</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>103</volume><issue>5</issue><spage>1705</spage><epage>1715</epage><pages>1705-1715</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT), and stratification of the high-risk group before transplantation is significant. Serum autotaxin (ATX) levels have been reported to increase in patients with liver fibrosis caused by metabolic inhibition from liver sinusoidal endothelial cells. Considering that the pathophysiology of VOD/SOS begins with liver sinusoidal endothelial cell injury, an increase in serum ATX levels may precede the onset of VOD/SOS. A retrospective study with 252 patients, including 12 patients with VOD/SOS, who had received allo-HCT was performed. The cumulative incidence of VOD/SOS was higher in the group with serum ATX levels before conditioning (baseline ATX) above the upper reference limit (high ATX group,
p
< 0.001), and 1-year cumulative incidences were 22.7% (95% confidence interval [95%CI], 3.1–42.4%) and 3.5% (95%CI, 1.1–5.8%), respectively. In the multivariate analysis, elevated baseline ATX was identified as an independent risk factor for VOD/SOS development and showed an additive effect on the predictive ability of known risk factors. Furthermore, the incidence of VOD/SOS-related mortality was greater in the high ATX group (16.7% vs. 1.3%;
p
= 0.005). Serum ATX is a potential predictive marker for the development of VOD/SOS.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38494552</pmid><doi>10.1007/s00277-024-05685-0</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9200-4804</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-5555 |
| ispartof | Annals of hematology, 2024-05, Vol.103 (5), p.1705-1715 |
| issn | 0939-5555 1432-0584 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2967058766 |
| source | SpringerLink Journals |
| subjects | Hematology Medicine Medicine & Public Health Oncology Original Article Stem cell transplantation |
| title | Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T09%3A27%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Autotaxin%20is%20a%20potential%20predictive%20marker%20for%20the%20development%20of%20veno-occlusive%20disease/sinusoidal%20obstruction%20syndrome%20after%20allogeneic%20hematopoietic%20cell%20transplantation&rft.jtitle=Annals%20of%20hematology&rft.au=Takemura,%20Kazuya&rft.date=2024-05-01&rft.volume=103&rft.issue=5&rft.spage=1705&rft.epage=1715&rft.pages=1705-1715&rft.issn=0939-5555&rft.eissn=1432-0584&rft_id=info:doi/10.1007/s00277-024-05685-0&rft_dat=%3Cproquest_cross%3E2967058766%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3037663239&rft_id=info:pmid/38494552&rfr_iscdi=true |