Design, synthesis and biological evaluation of Nrf2 modulators for the treatment of glioblastoma multiforme

We used virtual screening technology to discover and identify a compound, pinosylvin, that can effectively inhibit GBM proliferation. Pinosylvin exhibits strong hydrogen bonding and Π-Π interactions with Nrf2. Cellular experiments showed that pinosylvin effectively reduced the proliferation of U87 t...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2024-04, Vol.103, p.117684-117684, Article 117684
Hauptverfasser:	Yang, Huihui, Song, Peilu, Li, Baohu, Li, Shutang, Yang, Jinfei
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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