Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2 cells by releasing gingipain into the cytosol

Ingestion of Porphyromonas gingivalis, a periodontal pathogen, disrupts the intestinal barrier in mice. However, the involvement of outer membrane vesicles (OMVs) secreted from P. gingivalis in the destruction of the intestinal barrier remains unclear. In this study, we tested the hypothesis that OM...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-05, Vol.707, p.149783, Article 149783
Hauptverfasser:	Nonaka, Saori, Okamoto, Rin, Katsuta, Yui, Kanetsuki, Shiori, Nakanishi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - metabolism Animals Caco-2 Cells Caco-2 cell Cytosol - metabolism Gingipain Gingipain Cysteine Endopeptidases - metabolism Humans Mice Occludin Occludin - metabolism Outer membrabe vesicles Porphyromonas gingivalis Porphyromonas gingivalis - physiology
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