Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells

Breast cancer (BC) still poses a threat worldwide which demands continuous efforts to present safer and efficacious treatment options via targeted therapy. Beside kinases’ aberrations as Aurora B kinase which controls cell division, BC adopts distinct metabolic profiles to meet its high energy deman...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-03, Vol.268, p.116255-116255, Article 116255
Hauptverfasser:	Helmy, Sama W.A., Abdel-Aziz, Amal Kamal, Dokla, Eman M.E., Ahmed, Tarek E., Hatem, Yasmin, Abdel Rahman, Engy A., Sharaky, Marwa, Shahin, Mai I., Elrazaz, Eman Z., Serya, Rabah A.T., Henary, Maged, Ali, Sameh S., Abou El Ella, Dalal A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Aurora B Aurora Kinase B Bioinformatics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cell Line, Tumor Cell Proliferation Female Humans Indolinone hybrids Mitochondrial OXPHOS NCI-60 cell lines Oxindoles - pharmacology Sulfonamides - pharmacology Sulfonamides - therapeutic use
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