Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C‑terminal Hydrolase L1

Dysregulation of the ubiquitin-proteasome systems is a hallmark of various disease states including neurodegenerative diseases and cancer. Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is expressed primarily in the central nervous system under normal physiological conditions,...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-03, Vol.67 (6), p.4496-4524
Hauptverfasser:	Imhoff, Ryan D., Patel, Rishi, Safdar, Muhammad Hassan, Jones, Hannah B. L., Pinto-Fernandez, Adan, Vendrell, Iolanda, Chen, Hao, Muli, Christine S., Krabill, Aaron D., Kessler, Benedikt M., Wendt, Michael K., Das, Chittaranjan, Flaherty, Daniel P.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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