Effect of IQ-1 on the Infarct Size and the Parameters of Cardiodynamic Indicators in the Acute Period after Myocardial Ischemia/Reperfusion in Rats
The effect of a new JNK inhibitor IQ-1 (11 H -indeno[1,2- b ]quinoxalin-11-one oxime) was studied in male Wistar rats in a model of acute myocardial ischemia/reperfusion. Area at risk and myocardial infarct zones were studied in two series of experiments: 16 h after a single dose of IQ-1 (25 mg/kg i...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2024-02, Vol.176 (4), p.447-451 |
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| creator | Plotnikov, M. B. Chernysheva, G. A. Aliev, O. I. Smol’yakova, V. A. Sidekhmenova, A. V. Dunaeva, O. I. Khlebnikov, A. I. Plotnikova, T. M. |
| description | The effect of a new JNK inhibitor IQ-1 (11
H
-indeno[1,2-
b
]quinoxalin-11-one oxime) was studied in male Wistar rats in a model of acute myocardial ischemia/reperfusion. Area at risk and myocardial infarct zones were studied in two series of experiments: 16 h after a single dose of IQ-1 (25 mg/kg intraperitoneally during cardiac ischemia) and on day 5 after its course administration (25 mg/kg intraperitoneally during cardiac ischemia and daily over 4 days). On day 5 after ischemia/reperfusion, cardiodynamic indicators were also studied: systolic, end-diastolic, and minimum pressure in the left ventricle, stress—time index, as well as the maximum rates of pressure rise and fall in the left ventricle (+dP/dt
max
and -dP/dt
max
). In 16 h after ischemia/reperfusion, the infarct area in the control was 24±2% of the total area of the sections, while after administration of IQ-1 this parameter was 14±1% (
p |
| doi_str_mv | 10.1007/s10517-024-06044-9 |
| format | Article |
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H
-indeno[1,2-
b
]quinoxalin-11-one oxime) was studied in male Wistar rats in a model of acute myocardial ischemia/reperfusion. Area at risk and myocardial infarct zones were studied in two series of experiments: 16 h after a single dose of IQ-1 (25 mg/kg intraperitoneally during cardiac ischemia) and on day 5 after its course administration (25 mg/kg intraperitoneally during cardiac ischemia and daily over 4 days). On day 5 after ischemia/reperfusion, cardiodynamic indicators were also studied: systolic, end-diastolic, and minimum pressure in the left ventricle, stress—time index, as well as the maximum rates of pressure rise and fall in the left ventricle (+dP/dt
max
and -dP/dt
max
). In 16 h after ischemia/reperfusion, the infarct area in the control was 24±2% of the total area of the sections, while after administration of IQ-1 this parameter was 14±1% (
p
<0.05). On day 5, the infarct area in the control group was 25±1% of the total area of myocardial sections. A course of IQ-1 administration led to a significant reduction in the infarct area to 10±2% of the total area of myocardial slices. Course administration of IQ-1 led to improvement in contractile function and weakening of the diastolic dysfunction of the left ventricle: systolic pressure in the left ventricle increased by 20%, +dP/dt
max
by 23%, voltage—time index by 12%, -dP/dt
max
by 43%, and the minimum pressure in the left ventricle decreased by 3.4 times.</description><identifier>ISSN: 0007-4888</identifier><identifier>ISSN: 1573-8221</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-024-06044-9</identifier><identifier>PMID: 38491254</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal models ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood pressure ; Cell Biology ; Coronary Artery Disease ; Heart ; Intelligence ; Internal Medicine ; Ischemia ; Laboratory Medicine ; Male ; Muscle contraction ; Myocardial infarction ; Myocardial Infarction - drug therapy ; Myocardial ischemia ; Myocardial Reperfusion Injury - drug therapy ; Pathology ; Pharmacology and Toxicology ; Rats ; Rats, Wistar ; Reperfusion ; Ventricle</subject><ispartof>Bulletin of experimental biology and medicine, 2024-02, Vol.176 (4), p.447-451</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-8aa2278dea176f1332509d93ba18e98134b80a2d353b8d16dff3ad482ec6ca5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-024-06044-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-024-06044-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38491254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plotnikov, M. B.</creatorcontrib><creatorcontrib>Chernysheva, G. A.</creatorcontrib><creatorcontrib>Aliev, O. I.</creatorcontrib><creatorcontrib>Smol’yakova, V. A.</creatorcontrib><creatorcontrib>Sidekhmenova, A. V.</creatorcontrib><creatorcontrib>Dunaeva, O. I.</creatorcontrib><creatorcontrib>Khlebnikov, A. I.</creatorcontrib><creatorcontrib>Plotnikova, T. M.</creatorcontrib><title>Effect of IQ-1 on the Infarct Size and the Parameters of Cardiodynamic Indicators in the Acute Period after Myocardial Ischemia/Reperfusion in Rats</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>The effect of a new JNK inhibitor IQ-1 (11
H
-indeno[1,2-
b
]quinoxalin-11-one oxime) was studied in male Wistar rats in a model of acute myocardial ischemia/reperfusion. Area at risk and myocardial infarct zones were studied in two series of experiments: 16 h after a single dose of IQ-1 (25 mg/kg intraperitoneally during cardiac ischemia) and on day 5 after its course administration (25 mg/kg intraperitoneally during cardiac ischemia and daily over 4 days). On day 5 after ischemia/reperfusion, cardiodynamic indicators were also studied: systolic, end-diastolic, and minimum pressure in the left ventricle, stress—time index, as well as the maximum rates of pressure rise and fall in the left ventricle (+dP/dt
max
and -dP/dt
max
). In 16 h after ischemia/reperfusion, the infarct area in the control was 24±2% of the total area of the sections, while after administration of IQ-1 this parameter was 14±1% (
p
<0.05). On day 5, the infarct area in the control group was 25±1% of the total area of myocardial sections. A course of IQ-1 administration led to a significant reduction in the infarct area to 10±2% of the total area of myocardial slices. Course administration of IQ-1 led to improvement in contractile function and weakening of the diastolic dysfunction of the left ventricle: systolic pressure in the left ventricle increased by 20%, +dP/dt
max
by 23%, voltage—time index by 12%, -dP/dt
max
by 43%, and the minimum pressure in the left ventricle decreased by 3.4 times.</description><subject>Animal models</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood pressure</subject><subject>Cell Biology</subject><subject>Coronary Artery Disease</subject><subject>Heart</subject><subject>Intelligence</subject><subject>Internal Medicine</subject><subject>Ischemia</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Muscle contraction</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial ischemia</subject><subject>Myocardial Reperfusion Injury - drug therapy</subject><subject>Pathology</subject><subject>Pharmacology and Toxicology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reperfusion</subject><subject>Ventricle</subject><issn>0007-4888</issn><issn>1573-8221</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAURi1ERaeFF2CBLLFhk9Z_SZxlNSp0pKJCgbV1Y19TV5N4sJPF8Bq8cD1NAYkFK8u-53zX0kfIa87OOGPteeas5m3FhKpYw5SqumdkxetWVloI_pysWKEqpbU-Jic53x-urOEvyLHUquOiVivy69J7tBONnm4-V5zGkU53SDejh1Sev4SfSGF0j4-fIMGAE6Z8wNeQXIhuP8IQbBFcsDDFMgtLxIWdp-JgKhAFXzT6cR_twYIt3WR7h0OA81vcYfJzDmVzMW9hyi_JkYdtxldP5yn59v7y6_qqur75sFlfXFdWimaqNIAQrXYIvG08l1LUrHOd7IFr7DSXqtcMhJO17LXjjfNeglNaoG0s1L08Je-W3F2KP2bMkxlCtrjdwohxzkZ0tRadapu6oG__Qe_jnMbyu0JpxSRjnSqUWCibYs4JvdmlMEDaG87MoTKzVGZKZeaxMtMV6c1T9NwP6P4ovzsqgFyAXEbjd0x_d_8n9gE3E6FV</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Plotnikov, M. B.</creator><creator>Chernysheva, G. A.</creator><creator>Aliev, O. I.</creator><creator>Smol’yakova, V. A.</creator><creator>Sidekhmenova, A. V.</creator><creator>Dunaeva, O. I.</creator><creator>Khlebnikov, A. I.</creator><creator>Plotnikova, T. M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20240201</creationdate><title>Effect of IQ-1 on the Infarct Size and the Parameters of Cardiodynamic Indicators in the Acute Period after Myocardial Ischemia/Reperfusion in Rats</title><author>Plotnikov, M. B. ; Chernysheva, G. A. ; Aliev, O. I. ; Smol’yakova, V. A. ; Sidekhmenova, A. V. ; Dunaeva, O. I. ; Khlebnikov, A. I. ; Plotnikova, T. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-8aa2278dea176f1332509d93ba18e98134b80a2d353b8d16dff3ad482ec6ca5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood pressure</topic><topic>Cell Biology</topic><topic>Coronary Artery Disease</topic><topic>Heart</topic><topic>Intelligence</topic><topic>Internal Medicine</topic><topic>Ischemia</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Muscle contraction</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial ischemia</topic><topic>Myocardial Reperfusion Injury - drug therapy</topic><topic>Pathology</topic><topic>Pharmacology and Toxicology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reperfusion</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plotnikov, M. B.</creatorcontrib><creatorcontrib>Chernysheva, G. A.</creatorcontrib><creatorcontrib>Aliev, O. I.</creatorcontrib><creatorcontrib>Smol’yakova, V. A.</creatorcontrib><creatorcontrib>Sidekhmenova, A. V.</creatorcontrib><creatorcontrib>Dunaeva, O. I.</creatorcontrib><creatorcontrib>Khlebnikov, A. I.</creatorcontrib><creatorcontrib>Plotnikova, T. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plotnikov, M. B.</au><au>Chernysheva, G. A.</au><au>Aliev, O. I.</au><au>Smol’yakova, V. A.</au><au>Sidekhmenova, A. V.</au><au>Dunaeva, O. I.</au><au>Khlebnikov, A. I.</au><au>Plotnikova, T. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of IQ-1 on the Infarct Size and the Parameters of Cardiodynamic Indicators in the Acute Period after Myocardial Ischemia/Reperfusion in Rats</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>176</volume><issue>4</issue><spage>447</spage><epage>451</epage><pages>447-451</pages><issn>0007-4888</issn><issn>1573-8221</issn><eissn>1573-8221</eissn><abstract>The effect of a new JNK inhibitor IQ-1 (11
H
-indeno[1,2-
b
]quinoxalin-11-one oxime) was studied in male Wistar rats in a model of acute myocardial ischemia/reperfusion. Area at risk and myocardial infarct zones were studied in two series of experiments: 16 h after a single dose of IQ-1 (25 mg/kg intraperitoneally during cardiac ischemia) and on day 5 after its course administration (25 mg/kg intraperitoneally during cardiac ischemia and daily over 4 days). On day 5 after ischemia/reperfusion, cardiodynamic indicators were also studied: systolic, end-diastolic, and minimum pressure in the left ventricle, stress—time index, as well as the maximum rates of pressure rise and fall in the left ventricle (+dP/dt
max
and -dP/dt
max
). In 16 h after ischemia/reperfusion, the infarct area in the control was 24±2% of the total area of the sections, while after administration of IQ-1 this parameter was 14±1% (
p
<0.05). On day 5, the infarct area in the control group was 25±1% of the total area of myocardial sections. A course of IQ-1 administration led to a significant reduction in the infarct area to 10±2% of the total area of myocardial slices. Course administration of IQ-1 led to improvement in contractile function and weakening of the diastolic dysfunction of the left ventricle: systolic pressure in the left ventricle increased by 20%, +dP/dt
max
by 23%, voltage—time index by 12%, -dP/dt
max
by 43%, and the minimum pressure in the left ventricle decreased by 3.4 times.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38491254</pmid><doi>10.1007/s10517-024-06044-9</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animal models Animals Biomedical and Life Sciences Biomedicine Blood pressure Cell Biology Coronary Artery Disease Heart Intelligence Internal Medicine Ischemia Laboratory Medicine Male Muscle contraction Myocardial infarction Myocardial Infarction - drug therapy Myocardial ischemia Myocardial Reperfusion Injury - drug therapy Pathology Pharmacology and Toxicology Rats Rats, Wistar Reperfusion Ventricle |
| title | Effect of IQ-1 on the Infarct Size and the Parameters of Cardiodynamic Indicators in the Acute Period after Myocardial Ischemia/Reperfusion in Rats |
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