Effect of post-transplant diabetes mellitus on cardiovascular events and mortality: a single‐center retrospective cohort study
Purpose This study aims to investigate the impact of post-transplant diabetes mellitus (PTDM) on cardiovascular events, graft survival, and mortality and to determine the risk factors involved in developing PTDM. Methods A total of 703 patients who underwent kidney transplantation were included in t...
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| Veröffentlicht in: | Endocrine 2024-08, Vol.85 (2), p.695-703 |
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| creator | Ünlütürk, Uğur Yıldırım, Tolga Savaş, Merve Oğuz, Seda Hanife Fırlatan, Büşra Yüce, Deniz Karakaplan, Nesrin Damla Selimova, Cemile Yılmaz, Rahmi Erdem, Yunus Bayraktar, Miyase |
| description | Purpose
This study aims to investigate the impact of post-transplant diabetes mellitus (PTDM) on cardiovascular events, graft survival, and mortality and to determine the risk factors involved in developing PTDM.
Methods
A total of 703 patients who underwent kidney transplantation were included in the study. The total sample was subdivided into three groups: (i) patients with PTDM; (ii) patients who had diabetes before the transplantation (DM); and (iii) patients without diabetes (NoDM). The data on graft failure, cardiovascular events, all-cause mortality, and the potential risk factors that play a role in developing PTDM were recorded and analyzed.
Results
The patients were followed for a median of 80 (6–300) months after transplantation. Out of all patients, 41 (5.8%) had DM before transplantation, and 101 (14.4%) developed PTDM. Recipient BMI, post-transplant fasting plasma glucose, and hepatitis C seropositivity were independent risk factors for PTDM development. The incidence of cardiovascular events was 6.1% in the NoDM group, 14.9% in the PTDM group, and 29.3% in the DM group (
p
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| doi_str_mv | 10.1007/s12020-024-03770-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2958294535</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3086898051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-dfb3a8c9b4da26034d93e2e622cf409965276c5bb95dd630aa7d7f33a3963a13</originalsourceid><addsrcrecordid>eNp9kctu1jAQhS0EoqXwAiyQJTZsAo4dOzE7VJWLVIlN99bEnpRUSRw8zi9l10fgGXkSXP5yEQtWM9L55syMDmPPa_G6FqJ9Q7UUUlRCNpVQbSuq_QE7rbW2lSj6w7_6E_aE6EYIKaVpH7MT1TW2VsqestuLYUCfeRz4GilXOcFC6wRL5mGEHjMSn3GaxrwRjwv3kMIYD0B-myBxPOCSicMS-BxThsLtbzlwGpfrCb_ffvNFx8QT5hRpLZvGA3IfvxSYU97C_pQ9GmAifHZfz9jV-4ur84_V5ecPn87fXVZeSZOrMPQKOm_7JoA0QjXBKpRopPRDI6w1WrbG6763OgSjBEAb2kEpUNYoqNUZe3W0XVP8uiFlN4_ky2OwYNzISas7aRutdEFf_oPexC0t5TinRGc62wl9ZyiPlC-PUcLBrWmcIe2uFu4uHneMx5V43M943F6GXtxbb_2M4ffIrzwKoI4AFWm5xvRn939sfwAM5p7n</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3086898051</pqid></control><display><type>article</type><title>Effect of post-transplant diabetes mellitus on cardiovascular events and mortality: a single‐center retrospective cohort study</title><source>MEDLINE</source><source>Springer Online Journals</source><creator>Ünlütürk, Uğur ; Yıldırım, Tolga ; Savaş, Merve ; Oğuz, Seda Hanife ; Fırlatan, Büşra ; Yüce, Deniz ; Karakaplan, Nesrin Damla ; Selimova, Cemile ; Yılmaz, Rahmi ; Erdem, Yunus ; Bayraktar, Miyase</creator><creatorcontrib>Ünlütürk, Uğur ; Yıldırım, Tolga ; Savaş, Merve ; Oğuz, Seda Hanife ; Fırlatan, Büşra ; Yüce, Deniz ; Karakaplan, Nesrin Damla ; Selimova, Cemile ; Yılmaz, Rahmi ; Erdem, Yunus ; Bayraktar, Miyase</creatorcontrib><description>Purpose
This study aims to investigate the impact of post-transplant diabetes mellitus (PTDM) on cardiovascular events, graft survival, and mortality and to determine the risk factors involved in developing PTDM.
Methods
A total of 703 patients who underwent kidney transplantation were included in the study. The total sample was subdivided into three groups: (i) patients with PTDM; (ii) patients who had diabetes before the transplantation (DM); and (iii) patients without diabetes (NoDM). The data on graft failure, cardiovascular events, all-cause mortality, and the potential risk factors that play a role in developing PTDM were recorded and analyzed.
Results
The patients were followed for a median of 80 (6–300) months after transplantation. Out of all patients, 41 (5.8%) had DM before transplantation, and 101 (14.4%) developed PTDM. Recipient BMI, post-transplant fasting plasma glucose, and hepatitis C seropositivity were independent risk factors for PTDM development. The incidence of cardiovascular events was 6.1% in the NoDM group, 14.9% in the PTDM group, and 29.3% in the DM group (
p
< 0.001). In PTDM patients, hepatitis C seropositivity and the recipient’s age at transplant were independent predictors of a cardiovascular event. There were no significant differences between the groups regarding the risk of graft loss. PTDM had no significant effect on all-cause mortality. However, the survival rates of DM patients were significantly reduced compared to those with NoDM or PTDM.
Conclusions
PTDM had no impact on patient survival. Hepatitis C seropositivity and recipient age at transplant predicted cardiovascular events in PTDM patients.</description><identifier>ISSN: 1559-0100</identifier><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-024-03770-y</identifier><identifier>PMID: 38491339</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Diabetes Mellitus - etiology ; Endocrinology ; Female ; Graft rejection ; Graft Survival ; Hepatitis C ; Humanities and Social Sciences ; Humans ; Internal Medicine ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Kidney Transplantation - mortality ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; multidisciplinary ; Original Article ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Postoperative Complications - mortality ; Retrospective Studies ; Risk Factors ; Science ; Survival ; Transplants & implants</subject><ispartof>Endocrine, 2024-08, Vol.85 (2), p.695-703</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-dfb3a8c9b4da26034d93e2e622cf409965276c5bb95dd630aa7d7f33a3963a13</cites><orcidid>0000-0002-5054-1396</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-024-03770-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-024-03770-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38491339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ünlütürk, Uğur</creatorcontrib><creatorcontrib>Yıldırım, Tolga</creatorcontrib><creatorcontrib>Savaş, Merve</creatorcontrib><creatorcontrib>Oğuz, Seda Hanife</creatorcontrib><creatorcontrib>Fırlatan, Büşra</creatorcontrib><creatorcontrib>Yüce, Deniz</creatorcontrib><creatorcontrib>Karakaplan, Nesrin Damla</creatorcontrib><creatorcontrib>Selimova, Cemile</creatorcontrib><creatorcontrib>Yılmaz, Rahmi</creatorcontrib><creatorcontrib>Erdem, Yunus</creatorcontrib><creatorcontrib>Bayraktar, Miyase</creatorcontrib><title>Effect of post-transplant diabetes mellitus on cardiovascular events and mortality: a single‐center retrospective cohort study</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Purpose
This study aims to investigate the impact of post-transplant diabetes mellitus (PTDM) on cardiovascular events, graft survival, and mortality and to determine the risk factors involved in developing PTDM.
Methods
A total of 703 patients who underwent kidney transplantation were included in the study. The total sample was subdivided into three groups: (i) patients with PTDM; (ii) patients who had diabetes before the transplantation (DM); and (iii) patients without diabetes (NoDM). The data on graft failure, cardiovascular events, all-cause mortality, and the potential risk factors that play a role in developing PTDM were recorded and analyzed.
Results
The patients were followed for a median of 80 (6–300) months after transplantation. Out of all patients, 41 (5.8%) had DM before transplantation, and 101 (14.4%) developed PTDM. Recipient BMI, post-transplant fasting plasma glucose, and hepatitis C seropositivity were independent risk factors for PTDM development. The incidence of cardiovascular events was 6.1% in the NoDM group, 14.9% in the PTDM group, and 29.3% in the DM group (
p
< 0.001). In PTDM patients, hepatitis C seropositivity and the recipient’s age at transplant were independent predictors of a cardiovascular event. There were no significant differences between the groups regarding the risk of graft loss. PTDM had no significant effect on all-cause mortality. However, the survival rates of DM patients were significantly reduced compared to those with NoDM or PTDM.
Conclusions
PTDM had no impact on patient survival. Hepatitis C seropositivity and recipient age at transplant predicted cardiovascular events in PTDM patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes Mellitus - etiology</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Graft rejection</subject><subject>Graft Survival</subject><subject>Hepatitis C</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney Transplantation - mortality</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>multidisciplinary</subject><subject>Original Article</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - mortality</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Survival</subject><subject>Transplants & implants</subject><issn>1559-0100</issn><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1jAQhS0EoqXwAiyQJTZsAo4dOzE7VJWLVIlN99bEnpRUSRw8zi9l10fgGXkSXP5yEQtWM9L55syMDmPPa_G6FqJ9Q7UUUlRCNpVQbSuq_QE7rbW2lSj6w7_6E_aE6EYIKaVpH7MT1TW2VsqestuLYUCfeRz4GilXOcFC6wRL5mGEHjMSn3GaxrwRjwv3kMIYD0B-myBxPOCSicMS-BxThsLtbzlwGpfrCb_ffvNFx8QT5hRpLZvGA3IfvxSYU97C_pQ9GmAifHZfz9jV-4ur84_V5ecPn87fXVZeSZOrMPQKOm_7JoA0QjXBKpRopPRDI6w1WrbG6763OgSjBEAb2kEpUNYoqNUZe3W0XVP8uiFlN4_ky2OwYNzISas7aRutdEFf_oPexC0t5TinRGc62wl9ZyiPlC-PUcLBrWmcIe2uFu4uHneMx5V43M943F6GXtxbb_2M4ffIrzwKoI4AFWm5xvRn939sfwAM5p7n</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Ünlütürk, Uğur</creator><creator>Yıldırım, Tolga</creator><creator>Savaş, Merve</creator><creator>Oğuz, Seda Hanife</creator><creator>Fırlatan, Büşra</creator><creator>Yüce, Deniz</creator><creator>Karakaplan, Nesrin Damla</creator><creator>Selimova, Cemile</creator><creator>Yılmaz, Rahmi</creator><creator>Erdem, Yunus</creator><creator>Bayraktar, Miyase</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5054-1396</orcidid></search><sort><creationdate>20240801</creationdate><title>Effect of post-transplant diabetes mellitus on cardiovascular events and mortality: a single‐center retrospective cohort study</title><author>Ünlütürk, Uğur ; Yıldırım, Tolga ; Savaş, Merve ; Oğuz, Seda Hanife ; Fırlatan, Büşra ; Yüce, Deniz ; Karakaplan, Nesrin Damla ; Selimova, Cemile ; Yılmaz, Rahmi ; Erdem, Yunus ; Bayraktar, Miyase</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-dfb3a8c9b4da26034d93e2e622cf409965276c5bb95dd630aa7d7f33a3963a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes Mellitus - etiology</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Graft rejection</topic><topic>Graft Survival</topic><topic>Hepatitis C</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney Transplantation - mortality</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>multidisciplinary</topic><topic>Original Article</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - mortality</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Survival</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ünlütürk, Uğur</creatorcontrib><creatorcontrib>Yıldırım, Tolga</creatorcontrib><creatorcontrib>Savaş, Merve</creatorcontrib><creatorcontrib>Oğuz, Seda Hanife</creatorcontrib><creatorcontrib>Fırlatan, Büşra</creatorcontrib><creatorcontrib>Yüce, Deniz</creatorcontrib><creatorcontrib>Karakaplan, Nesrin Damla</creatorcontrib><creatorcontrib>Selimova, Cemile</creatorcontrib><creatorcontrib>Yılmaz, Rahmi</creatorcontrib><creatorcontrib>Erdem, Yunus</creatorcontrib><creatorcontrib>Bayraktar, Miyase</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ünlütürk, Uğur</au><au>Yıldırım, Tolga</au><au>Savaş, Merve</au><au>Oğuz, Seda Hanife</au><au>Fırlatan, Büşra</au><au>Yüce, Deniz</au><au>Karakaplan, Nesrin Damla</au><au>Selimova, Cemile</au><au>Yılmaz, Rahmi</au><au>Erdem, Yunus</au><au>Bayraktar, Miyase</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of post-transplant diabetes mellitus on cardiovascular events and mortality: a single‐center retrospective cohort study</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>85</volume><issue>2</issue><spage>695</spage><epage>703</epage><pages>695-703</pages><issn>1559-0100</issn><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
This study aims to investigate the impact of post-transplant diabetes mellitus (PTDM) on cardiovascular events, graft survival, and mortality and to determine the risk factors involved in developing PTDM.
Methods
A total of 703 patients who underwent kidney transplantation were included in the study. The total sample was subdivided into three groups: (i) patients with PTDM; (ii) patients who had diabetes before the transplantation (DM); and (iii) patients without diabetes (NoDM). The data on graft failure, cardiovascular events, all-cause mortality, and the potential risk factors that play a role in developing PTDM were recorded and analyzed.
Results
The patients were followed for a median of 80 (6–300) months after transplantation. Out of all patients, 41 (5.8%) had DM before transplantation, and 101 (14.4%) developed PTDM. Recipient BMI, post-transplant fasting plasma glucose, and hepatitis C seropositivity were independent risk factors for PTDM development. The incidence of cardiovascular events was 6.1% in the NoDM group, 14.9% in the PTDM group, and 29.3% in the DM group (
p
< 0.001). In PTDM patients, hepatitis C seropositivity and the recipient’s age at transplant were independent predictors of a cardiovascular event. There were no significant differences between the groups regarding the risk of graft loss. PTDM had no significant effect on all-cause mortality. However, the survival rates of DM patients were significantly reduced compared to those with NoDM or PTDM.
Conclusions
PTDM had no impact on patient survival. Hepatitis C seropositivity and recipient age at transplant predicted cardiovascular events in PTDM patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38491339</pmid><doi>10.1007/s12020-024-03770-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5054-1396</orcidid></addata></record> |
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| ispartof | Endocrine, 2024-08, Vol.85 (2), p.695-703 |
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| subjects | Adult Aged Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Diabetes Diabetes mellitus Diabetes Mellitus - epidemiology Diabetes Mellitus - etiology Endocrinology Female Graft rejection Graft Survival Hepatitis C Humanities and Social Sciences Humans Internal Medicine Kidney transplantation Kidney Transplantation - adverse effects Kidney Transplantation - mortality Male Medicine Medicine & Public Health Middle Aged Mortality multidisciplinary Original Article Postoperative Complications - epidemiology Postoperative Complications - etiology Postoperative Complications - mortality Retrospective Studies Risk Factors Science Survival Transplants & implants |
| title | Effect of post-transplant diabetes mellitus on cardiovascular events and mortality: a single‐center retrospective cohort study |
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