Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi

Dental calculi can cause gingival bleeding and periodontitis, yet the mechanism underlying the formation of such mineral build-ups, and in particular the role of the local microenvironment, are unclear. Here we show that the formation of dental calculi involves bacteria in local mature biofilms conv...

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Veröffentlicht in:	Nature biomedical engineering 2024-09, Vol.8 (9), p.1177-1190
Hauptverfasser:	Wan, Mei-chen, Jiao, Kai, Zhu, Yi-na, Wan, Qian-qian, Zhang, Yi-peng, Niu, Long-zhang, Lei, Chen, Song, Jing-han, Lu, Wei-cheng, Liu, Hua-jie, Ren, Zhao-yang, Tay, Franklin, Niu, Li-na
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 631/250/262 631/326/46 692/4023/1671/63 Animals Apatite Bacteria Bacteria - metabolism Biodegradation Biofilms Biofilms - growth & development Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Chloroquine Degradation Dental calculi Dental calculus Dental Calculus - metabolism Dental materials Deoxyribonuclease Deoxyribonuclease I - metabolism Deoxyribonucleic acid DNA Enzymes Extracellular Traps - metabolism Humans Leukocytes (neutrophilic) Male Mice Microenvironments Mineralization Neutrophils Neutrophils - metabolism Nucleation Oral cavity Periodontitis Pharmacology Rats Rodents Topical application
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