Mutagenesis techniques for evolutionary engineering of microbes – exploiting CRISPR-Cas, oligonucleotides, recombinases, and polymerases

Evolving microbes for desirable phenotypes, including stress resistance or the production of specific compounds, is a powerful approach in biotechnology and precision fermentation.Genetic diversity is essential for evolving microorganisms as it provides the raw material for screening/selection of im...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2024-09, Vol.32 (9), p.884-901
Hauptverfasser:	Zimmermann, Anna, Prieto-Vivas, Julian E., Voordeckers, Karin, Bi, Changhao, Verstrepen, Kevin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria - genetics CRISPR-Cas Systems directed evolution Directed Molecular Evolution - methods engineering microbes Genetic Engineering - methods Metabolic Engineering - methods metabolic optimization Mutagenesis Oligonucleotides - genetics precision fermentation Recombinases - genetics Recombinases - metabolism Synthetic Biology - methods targeted mutagenesis
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