Microglial AT1R Conditional Knockout Ameliorates Hypoperfusive Cognitive Impairment by Reducing Microglial Inflammatory Responses

•Hippocampal microglial AT1R may contribute to cognitive impairment caused by CCH.•Microglial AT1R cKO can reduce microglial inflammatory responses and activation.•Candesartan may be a feasible drug for ameliorating cognitive impairments.•Ctss, Fcer1g, Tyrobp play an essential role in cognitive impa...

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Veröffentlicht in:	Neuroscience 2024-05, Vol.545, p.125-140
Hauptverfasser:	Li, Deyue, Zhang, Qiao, Yang, Xia, Zhang, Guoqing, Wang, Jinping, Zhang, Rong, Liu, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AT1R Benzimidazoles - pharmacology Biphenyl Compounds - pharmacology candesartan Carotid Stenosis - complications Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology chronic cerebral hypoperfusion Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism cognitive impairment Disease Models, Animal Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology inflammatory responses Male Mice Mice, Inbred C57BL Mice, Knockout Microglia - drug effects Microglia - metabolism Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Tetrazoles - pharmacology
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