Incidence rates of thrombosis with thrombocytopenia syndrome (TTS) among adults in United States commercial and Medicare claims databases, 2017–2020
•Annual TTS IRs were similar between Jan-Dec 2019 and Jan-Oct 2020.•Common site TTS IRs increased with age and were higher among males.•Unusual site TTS IRs were higher in males than females.•Unusual site TTS IRs increased with age for adults aged 18–64 years.•For adults aged ≥ 65 years, unusual sit...
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| Veröffentlicht in: | Vaccine 2024-03, Vol.42 (8), p.2004-2010 |
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| creator | Lloyd, Patricia C. Lufkin, Bradley Moll, Keran Ogilvie, Rachel P. McMahill-Walraven, Cheryl N. Beachler, Daniel C. Kelman, Jeffrey A. Shi, Xiangyu Hobbi, Shayan Amend, Kandace L. Djibo, Djeneba Audrey Shangguan, Shanlai Shoaibi, Azadeh Sheng, Minya Secora, Alex Zhou, Cindy Ke Kowarski, Lisa Chillarige, Yoganand Forshee, Richard A. Anderson, Steven A. Muthuri, Stella Seeger, John D. Kline, Annemarie Reich, Christian MaCurdy, Thomas Wong, Hui Lee |
| description | •Annual TTS IRs were similar between Jan-Dec 2019 and Jan-Oct 2020.•Common site TTS IRs increased with age and were higher among males.•Unusual site TTS IRs were higher in males than females.•Unusual site TTS IRs increased with age for adults aged 18–64 years.•For adults aged ≥ 65 years, unusual site TTS IRs decreased with age.
Increased risk of thrombosis with thrombocytopenia syndrome (TTS) following adenovirus vector-based COVID-19 vaccinations has been identified in passive surveillance systems. TTS incidence rates (IRs) in the United States (U.S.) are needed to contextualize reports following COVID-19 vaccination.
We estimated annual and monthly IRs of overall TTS, common site TTS, and unusual site TTS for adults aged 18–64 years in Carelon Research and MarketScan commercial claims (2017–Oct 2020), CVS Health and Optum commercial claims (2019–Oct 2020), and adults aged ≥ 65 years using CMS Medicare claims (2019–Oct 2020); IRs were stratified by age, sex, and race/ethnicity (CMS Medicare).
Across data sources, annual IRs for overall TTS were similar between Jan-Dec 2019 and Jan-Oct 2020. Rates were higher in Medicare (IRs: 370.72 and 365.63 per 100,000 person-years for 2019 and 2020, respectively) than commercial data sources (MarketScan IRs: 24.21 and 24.06 per 100,000 person-years; Optum IRs: 32.60 and 31.29 per 100,000 person-years; Carelon Research IRs: 24.46 and 26.16 per 100,000 person-years; CVS Health IRs: 30.31 and 30.25 per 100,000 person-years). Across years and databases, common site TTS IRs increased with age and were higher among males. Among adults aged ≥ 65 years, the common site TTS IR was highest among non-Hispanic black adults. Annual unusual site TTS IRs ranged between 2.02 and 3.04 (commercial) and 12.49 (Medicare) per 100,000 person-years for Jan-Dec 2019; IRs ranged between 1.53 and 2.67 (commercial) and 11.57 (Medicare) per 100,000 person-years for Jan-Oct 2020. Unusual site TTS IRs were higher in males and increased with age in commercial data sources; among adults aged ≥ 65 years, IRs decreased with age and were highest among non-Hispanic American Indian/Alaska native adults.
TTS IRs were generally similar across years, higher for males, and increased with age. These rates may contribute to surveillance of post-vaccination TTS. |
| doi_str_mv | 10.1016/j.vaccine.2024.02.017 |
| format | Article |
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Increased risk of thrombosis with thrombocytopenia syndrome (TTS) following adenovirus vector-based COVID-19 vaccinations has been identified in passive surveillance systems. TTS incidence rates (IRs) in the United States (U.S.) are needed to contextualize reports following COVID-19 vaccination.
We estimated annual and monthly IRs of overall TTS, common site TTS, and unusual site TTS for adults aged 18–64 years in Carelon Research and MarketScan commercial claims (2017–Oct 2020), CVS Health and Optum commercial claims (2019–Oct 2020), and adults aged ≥ 65 years using CMS Medicare claims (2019–Oct 2020); IRs were stratified by age, sex, and race/ethnicity (CMS Medicare).
Across data sources, annual IRs for overall TTS were similar between Jan-Dec 2019 and Jan-Oct 2020. Rates were higher in Medicare (IRs: 370.72 and 365.63 per 100,000 person-years for 2019 and 2020, respectively) than commercial data sources (MarketScan IRs: 24.21 and 24.06 per 100,000 person-years; Optum IRs: 32.60 and 31.29 per 100,000 person-years; Carelon Research IRs: 24.46 and 26.16 per 100,000 person-years; CVS Health IRs: 30.31 and 30.25 per 100,000 person-years). Across years and databases, common site TTS IRs increased with age and were higher among males. Among adults aged ≥ 65 years, the common site TTS IR was highest among non-Hispanic black adults. Annual unusual site TTS IRs ranged between 2.02 and 3.04 (commercial) and 12.49 (Medicare) per 100,000 person-years for Jan-Dec 2019; IRs ranged between 1.53 and 2.67 (commercial) and 11.57 (Medicare) per 100,000 person-years for Jan-Oct 2020. Unusual site TTS IRs were higher in males and increased with age in commercial data sources; among adults aged ≥ 65 years, IRs decreased with age and were highest among non-Hispanic American Indian/Alaska native adults.
TTS IRs were generally similar across years, higher for males, and increased with age. These rates may contribute to surveillance of post-vaccination TTS.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2024.02.017</identifier><identifier>PMID: 38388240</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adults ; Age ; Algorithms ; Background rates ; Coronaviruses ; COVID-19 ; COVID-19 vaccine ; COVID-19 vaccines ; Data sources ; Ethnicity ; Government programs ; Heart attacks ; Immunization ; Males ; Medicare ; Nursing homes ; Pandemics ; Population ; Pulmonary embolisms ; Surveillance systems ; Thrombocytopenia ; Thromboembolism ; Thrombosis ; Thrombosis with thrombocytopenia syndrome (TTS) ; Vaccination</subject><ispartof>Vaccine, 2024-03, Vol.42 (8), p.2004-2010</ispartof><rights>2024</rights><rights>Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Mar 19, 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c341t-7307a947c862aaf2fb083f8795355a8f6f0311a6f10eaa02353509ff19c79fa13</cites><orcidid>0000-0001-5105-1631 ; 0000-0002-6502-5212 ; 0000-0002-2892-0648 ; 0000-0002-1333-6262 ; 0000-0003-0987-7450 ; 0000-0003-2392-0494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X24001646$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38388240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lloyd, Patricia C.</creatorcontrib><creatorcontrib>Lufkin, Bradley</creatorcontrib><creatorcontrib>Moll, Keran</creatorcontrib><creatorcontrib>Ogilvie, Rachel P.</creatorcontrib><creatorcontrib>McMahill-Walraven, Cheryl N.</creatorcontrib><creatorcontrib>Beachler, Daniel C.</creatorcontrib><creatorcontrib>Kelman, Jeffrey A.</creatorcontrib><creatorcontrib>Shi, Xiangyu</creatorcontrib><creatorcontrib>Hobbi, Shayan</creatorcontrib><creatorcontrib>Amend, Kandace L.</creatorcontrib><creatorcontrib>Djibo, Djeneba Audrey</creatorcontrib><creatorcontrib>Shangguan, Shanlai</creatorcontrib><creatorcontrib>Shoaibi, Azadeh</creatorcontrib><creatorcontrib>Sheng, Minya</creatorcontrib><creatorcontrib>Secora, Alex</creatorcontrib><creatorcontrib>Zhou, Cindy Ke</creatorcontrib><creatorcontrib>Kowarski, Lisa</creatorcontrib><creatorcontrib>Chillarige, Yoganand</creatorcontrib><creatorcontrib>Forshee, Richard A.</creatorcontrib><creatorcontrib>Anderson, Steven A.</creatorcontrib><creatorcontrib>Muthuri, Stella</creatorcontrib><creatorcontrib>Seeger, John D.</creatorcontrib><creatorcontrib>Kline, Annemarie</creatorcontrib><creatorcontrib>Reich, Christian</creatorcontrib><creatorcontrib>MaCurdy, Thomas</creatorcontrib><creatorcontrib>Wong, Hui Lee</creatorcontrib><title>Incidence rates of thrombosis with thrombocytopenia syndrome (TTS) among adults in United States commercial and Medicare claims databases, 2017–2020</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>•Annual TTS IRs were similar between Jan-Dec 2019 and Jan-Oct 2020.•Common site TTS IRs increased with age and were higher among males.•Unusual site TTS IRs were higher in males than females.•Unusual site TTS IRs increased with age for adults aged 18–64 years.•For adults aged ≥ 65 years, unusual site TTS IRs decreased with age.
Increased risk of thrombosis with thrombocytopenia syndrome (TTS) following adenovirus vector-based COVID-19 vaccinations has been identified in passive surveillance systems. TTS incidence rates (IRs) in the United States (U.S.) are needed to contextualize reports following COVID-19 vaccination.
We estimated annual and monthly IRs of overall TTS, common site TTS, and unusual site TTS for adults aged 18–64 years in Carelon Research and MarketScan commercial claims (2017–Oct 2020), CVS Health and Optum commercial claims (2019–Oct 2020), and adults aged ≥ 65 years using CMS Medicare claims (2019–Oct 2020); IRs were stratified by age, sex, and race/ethnicity (CMS Medicare).
Across data sources, annual IRs for overall TTS were similar between Jan-Dec 2019 and Jan-Oct 2020. Rates were higher in Medicare (IRs: 370.72 and 365.63 per 100,000 person-years for 2019 and 2020, respectively) than commercial data sources (MarketScan IRs: 24.21 and 24.06 per 100,000 person-years; Optum IRs: 32.60 and 31.29 per 100,000 person-years; Carelon Research IRs: 24.46 and 26.16 per 100,000 person-years; CVS Health IRs: 30.31 and 30.25 per 100,000 person-years). Across years and databases, common site TTS IRs increased with age and were higher among males. Among adults aged ≥ 65 years, the common site TTS IR was highest among non-Hispanic black adults. Annual unusual site TTS IRs ranged between 2.02 and 3.04 (commercial) and 12.49 (Medicare) per 100,000 person-years for Jan-Dec 2019; IRs ranged between 1.53 and 2.67 (commercial) and 11.57 (Medicare) per 100,000 person-years for Jan-Oct 2020. Unusual site TTS IRs were higher in males and increased with age in commercial data sources; among adults aged ≥ 65 years, IRs decreased with age and were highest among non-Hispanic American Indian/Alaska native adults.
TTS IRs were generally similar across years, higher for males, and increased with age. These rates may contribute to surveillance of post-vaccination TTS.</description><subject>Adults</subject><subject>Age</subject><subject>Algorithms</subject><subject>Background rates</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 vaccine</subject><subject>COVID-19 vaccines</subject><subject>Data sources</subject><subject>Ethnicity</subject><subject>Government programs</subject><subject>Heart attacks</subject><subject>Immunization</subject><subject>Males</subject><subject>Medicare</subject><subject>Nursing homes</subject><subject>Pandemics</subject><subject>Population</subject><subject>Pulmonary embolisms</subject><subject>Surveillance systems</subject><subject>Thrombocytopenia</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Thrombosis with thrombocytopenia syndrome 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(Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lloyd, Patricia C.</au><au>Lufkin, Bradley</au><au>Moll, Keran</au><au>Ogilvie, Rachel P.</au><au>McMahill-Walraven, Cheryl N.</au><au>Beachler, Daniel C.</au><au>Kelman, Jeffrey A.</au><au>Shi, Xiangyu</au><au>Hobbi, Shayan</au><au>Amend, Kandace L.</au><au>Djibo, Djeneba Audrey</au><au>Shangguan, Shanlai</au><au>Shoaibi, Azadeh</au><au>Sheng, Minya</au><au>Secora, Alex</au><au>Zhou, Cindy Ke</au><au>Kowarski, Lisa</au><au>Chillarige, Yoganand</au><au>Forshee, Richard A.</au><au>Anderson, Steven A.</au><au>Muthuri, Stella</au><au>Seeger, John D.</au><au>Kline, Annemarie</au><au>Reich, Christian</au><au>MaCurdy, Thomas</au><au>Wong, Hui Lee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence rates of thrombosis with thrombocytopenia syndrome (TTS) among adults in United States commercial and Medicare claims databases, 2017–2020</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2024-03-19</date><risdate>2024</risdate><volume>42</volume><issue>8</issue><spage>2004</spage><epage>2010</epage><pages>2004-2010</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>•Annual TTS IRs were similar between Jan-Dec 2019 and Jan-Oct 2020.•Common site TTS IRs increased with age and were higher among males.•Unusual site TTS IRs were higher in males than females.•Unusual site TTS IRs increased with age for adults aged 18–64 years.•For adults aged ≥ 65 years, unusual site TTS IRs decreased with age.
Increased risk of thrombosis with thrombocytopenia syndrome (TTS) following adenovirus vector-based COVID-19 vaccinations has been identified in passive surveillance systems. TTS incidence rates (IRs) in the United States (U.S.) are needed to contextualize reports following COVID-19 vaccination.
We estimated annual and monthly IRs of overall TTS, common site TTS, and unusual site TTS for adults aged 18–64 years in Carelon Research and MarketScan commercial claims (2017–Oct 2020), CVS Health and Optum commercial claims (2019–Oct 2020), and adults aged ≥ 65 years using CMS Medicare claims (2019–Oct 2020); IRs were stratified by age, sex, and race/ethnicity (CMS Medicare).
Across data sources, annual IRs for overall TTS were similar between Jan-Dec 2019 and Jan-Oct 2020. Rates were higher in Medicare (IRs: 370.72 and 365.63 per 100,000 person-years for 2019 and 2020, respectively) than commercial data sources (MarketScan IRs: 24.21 and 24.06 per 100,000 person-years; Optum IRs: 32.60 and 31.29 per 100,000 person-years; Carelon Research IRs: 24.46 and 26.16 per 100,000 person-years; CVS Health IRs: 30.31 and 30.25 per 100,000 person-years). Across years and databases, common site TTS IRs increased with age and were higher among males. Among adults aged ≥ 65 years, the common site TTS IR was highest among non-Hispanic black adults. Annual unusual site TTS IRs ranged between 2.02 and 3.04 (commercial) and 12.49 (Medicare) per 100,000 person-years for Jan-Dec 2019; IRs ranged between 1.53 and 2.67 (commercial) and 11.57 (Medicare) per 100,000 person-years for Jan-Oct 2020. Unusual site TTS IRs were higher in males and increased with age in commercial data sources; among adults aged ≥ 65 years, IRs decreased with age and were highest among non-Hispanic American Indian/Alaska native adults.
TTS IRs were generally similar across years, higher for males, and increased with age. These rates may contribute to surveillance of post-vaccination TTS.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>38388240</pmid><doi>10.1016/j.vaccine.2024.02.017</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5105-1631</orcidid><orcidid>https://orcid.org/0000-0002-6502-5212</orcidid><orcidid>https://orcid.org/0000-0002-2892-0648</orcidid><orcidid>https://orcid.org/0000-0002-1333-6262</orcidid><orcidid>https://orcid.org/0000-0003-0987-7450</orcidid><orcidid>https://orcid.org/0000-0003-2392-0494</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2024-03, Vol.42 (8), p.2004-2010 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2958291473 |
| source | Elsevier ScienceDirect Journals |
| subjects | Adults Age Algorithms Background rates Coronaviruses COVID-19 COVID-19 vaccine COVID-19 vaccines Data sources Ethnicity Government programs Heart attacks Immunization Males Medicare Nursing homes Pandemics Population Pulmonary embolisms Surveillance systems Thrombocytopenia Thromboembolism Thrombosis Thrombosis with thrombocytopenia syndrome (TTS) Vaccination |
| title | Incidence rates of thrombosis with thrombocytopenia syndrome (TTS) among adults in United States commercial and Medicare claims databases, 2017–2020 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T11%3A15%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incidence%20rates%20of%20thrombosis%20with%20thrombocytopenia%20syndrome%20(TTS)%20among%20adults%20in%20United%20States%20commercial%20and%20Medicare%20claims%20databases,%202017%E2%80%932020&rft.jtitle=Vaccine&rft.au=Lloyd,%20Patricia%20C.&rft.date=2024-03-19&rft.volume=42&rft.issue=8&rft.spage=2004&rft.epage=2010&rft.pages=2004-2010&rft.issn=0264-410X&rft.eissn=1873-2518&rft_id=info:doi/10.1016/j.vaccine.2024.02.017&rft_dat=%3Cproquest_cross%3E2956720264%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2956720264&rft_id=info:pmid/38388240&rft_els_id=S0264410X24001646&rfr_iscdi=true |