GFAP-isoforms in the nervous system: Understanding the need for diversity

GFAP-isoforms in the nervous system: Understanding the need for diversity

Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell t...

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Veröffentlicht in:Current opinion in cell biology 2024-04, Vol.87, p.102340-102340, Article 102340
Hauptverfasser: de Reus, Alexandra J.E.M., Basak, Onur, Dykstra, Werner, van Asperen, Jessy V., van Bodegraven, Emma J., Hol, Elly M.
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container_title Current opinion in cell biology
container_volume 87
creator de Reus, Alexandra J.E.M.
Basak, Onur
Dykstra, Werner
van Asperen, Jessy V.
van Bodegraven, Emma J.
Hol, Elly M.
description Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly properties, and IF-dynamics which results in distinct molecular interactions and mechanical properties of the IF-network. Therefore, GFAP (post-)transcriptional regulation is likely a mechanism by which radial glia, astrocytes, and glioma cells can modulate cellular function. [Display omitted]
doi_str_mv 10.1016/j.ceb.2024.102340
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