MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma
Objective This study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA), residual PA, and carcinoma ex pleomorphic adenoma (CXPA). Materials and Methods We analyzed 13 PA, 4 RPA,...
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| Veröffentlicht in: | Head & neck 2024-05, Vol.46 (5), p.985-1000 |
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| creator | Kimura, Talita de Carvalho Scarini, João Figueira Lavareze, Luccas Kowalski, Luiz Paulo Coutinho‐Camillo, Cláudia Malheiros Krepischi, Ana Cristina Victorino Egal, Erika Said Abu Altemani, Albina Mariano, Fernanda Viviane |
| description | Objective
This study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA), residual PA, and carcinoma ex pleomorphic adenoma (CXPA).
Materials and Methods
We analyzed 13 PA, 4 RPA, 29 CXPA, and 14 residual PA using Nexus Copy Number Discovery software. The miRNAs genes affected by CNAs were evaluated based on their expression patterns and subjected to pathway enrichment analysis.
Results
Across the groups, we found 216 CNAs affecting 2261 miRNA genes, with 117 in PA, 59 in RPA, 846 in residual PA, and 2555 in CXPA. The chromosome 8 showed higher involvement in altered miRNAs in PAs and CXPA patients. Six miRNA genes were shared among all groups. Additionally, miR‐21, miR‐455‐3p, miR‐140, miR‐320a, miR‐383, miR‐598, and miR‐486 were prominent CNAs found and is implicated in carcinogenesis of several malignant tumors. These miRNAs regulate critical signaling pathways such as aerobic glycolysis, fatty acid biosynthesis, and cancer‐related pathways.
Conclusion
This study was the first to explore CNAs in miRNA‐encoding genes in the PA‐CXPA sequence. The findings suggest the involvement of numerous miRNA genes in CXPA development and progression by regulating oncogenic signaling pathways. |
| doi_str_mv | 10.1002/hed.27717 |
| format | Article |
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This study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA), residual PA, and carcinoma ex pleomorphic adenoma (CXPA).
Materials and Methods
We analyzed 13 PA, 4 RPA, 29 CXPA, and 14 residual PA using Nexus Copy Number Discovery software. The miRNAs genes affected by CNAs were evaluated based on their expression patterns and subjected to pathway enrichment analysis.
Results
Across the groups, we found 216 CNAs affecting 2261 miRNA genes, with 117 in PA, 59 in RPA, 846 in residual PA, and 2555 in CXPA. The chromosome 8 showed higher involvement in altered miRNAs in PAs and CXPA patients. Six miRNA genes were shared among all groups. Additionally, miR‐21, miR‐455‐3p, miR‐140, miR‐320a, miR‐383, miR‐598, and miR‐486 were prominent CNAs found and is implicated in carcinogenesis of several malignant tumors. These miRNAs regulate critical signaling pathways such as aerobic glycolysis, fatty acid biosynthesis, and cancer‐related pathways.
Conclusion
This study was the first to explore CNAs in miRNA‐encoding genes in the PA‐CXPA sequence. The findings suggest the involvement of numerous miRNA genes in CXPA development and progression by regulating oncogenic signaling pathways.</description><identifier>ISSN: 1043-3074</identifier><identifier>ISSN: 1097-0347</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27717</identifier><identifier>PMID: 38482546</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adenoma ; Carcinogenesis ; Carcinoma ; carcinoma ex pleomorphic adenoma ; Chromosome 8 ; comparative genomic hybridization ; Copy number ; copy number alteration ; copy number variation ; Glycolysis ; Hybridization ; MicroRNAs ; miRNA ; pleomorphic adenoma ; Signal transduction ; Tumors</subject><ispartof>Head & neck, 2024-05, Vol.46 (5), p.985-1000</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3137-e291029c37326e300335499e5aa041a1194168926b823d051ac74d053706cc803</cites><orcidid>0000-0001-8406-7947 ; 0000-0003-3694-5025</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.27717$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.27717$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38482546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimura, Talita de Carvalho</creatorcontrib><creatorcontrib>Scarini, João Figueira</creatorcontrib><creatorcontrib>Lavareze, Luccas</creatorcontrib><creatorcontrib>Kowalski, Luiz Paulo</creatorcontrib><creatorcontrib>Coutinho‐Camillo, Cláudia Malheiros</creatorcontrib><creatorcontrib>Krepischi, Ana Cristina Victorino</creatorcontrib><creatorcontrib>Egal, Erika Said Abu</creatorcontrib><creatorcontrib>Altemani, Albina</creatorcontrib><creatorcontrib>Mariano, Fernanda Viviane</creatorcontrib><title>MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Objective
This study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA), residual PA, and carcinoma ex pleomorphic adenoma (CXPA).
Materials and Methods
We analyzed 13 PA, 4 RPA, 29 CXPA, and 14 residual PA using Nexus Copy Number Discovery software. The miRNAs genes affected by CNAs were evaluated based on their expression patterns and subjected to pathway enrichment analysis.
Results
Across the groups, we found 216 CNAs affecting 2261 miRNA genes, with 117 in PA, 59 in RPA, 846 in residual PA, and 2555 in CXPA. The chromosome 8 showed higher involvement in altered miRNAs in PAs and CXPA patients. Six miRNA genes were shared among all groups. Additionally, miR‐21, miR‐455‐3p, miR‐140, miR‐320a, miR‐383, miR‐598, and miR‐486 were prominent CNAs found and is implicated in carcinogenesis of several malignant tumors. These miRNAs regulate critical signaling pathways such as aerobic glycolysis, fatty acid biosynthesis, and cancer‐related pathways.
Conclusion
This study was the first to explore CNAs in miRNA‐encoding genes in the PA‐CXPA sequence. The findings suggest the involvement of numerous miRNA genes in CXPA development and progression by regulating oncogenic signaling pathways.</description><subject>Adenoma</subject><subject>Carcinogenesis</subject><subject>Carcinoma</subject><subject>carcinoma ex pleomorphic adenoma</subject><subject>Chromosome 8</subject><subject>comparative genomic hybridization</subject><subject>Copy number</subject><subject>copy number alteration</subject><subject>copy number variation</subject><subject>Glycolysis</subject><subject>Hybridization</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>pleomorphic adenoma</subject><subject>Signal transduction</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kUtLxDAUhYMoPkYX_gEJuNFFnbzaNEsZHyP4ANF1yGRSJ9ImNWnRwT9vnDob0dV98HG49xwADjE6wwiR8cLMzwjnmG-AXYwEzxBlfPO7ZzSjiLMdsBfjK0KIFoxsgx1aspLkrNgFn3dWB_94fw61b5fQ9c3MBKjqzgTVWe8itA52CwMbVdsXp1wHu6BcrHxoVgD0FWxr4xsf2oXVUM2N842CnYdaBW1Xg_n4i9kHW5Wqozn4qSPwfHX5NJlmtw_XN5Pz20xTTHlmiMCICE05JYWh6QmaMyFMrhRiWGEsGC5KQYpZSegc5VhpzlKlHBVal4iOwMmg2wb_1pvYycZGbepaOeP7KInIOS5E8imhx7_QV98Hl66TNJla0FKUPFGnA5WsizGYSrbBNiosJUbyOxGZEpGrRBJ79KPYz5q0XZPrCBIwHoB3W5vl_0pyenkxSH4BovuUTQ</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Kimura, Talita de Carvalho</creator><creator>Scarini, João Figueira</creator><creator>Lavareze, Luccas</creator><creator>Kowalski, Luiz Paulo</creator><creator>Coutinho‐Camillo, Cláudia Malheiros</creator><creator>Krepischi, Ana Cristina Victorino</creator><creator>Egal, Erika Said Abu</creator><creator>Altemani, Albina</creator><creator>Mariano, Fernanda Viviane</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8406-7947</orcidid><orcidid>https://orcid.org/0000-0003-3694-5025</orcidid></search><sort><creationdate>202405</creationdate><title>MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma</title><author>Kimura, Talita de Carvalho ; Scarini, João Figueira ; Lavareze, Luccas ; Kowalski, Luiz Paulo ; Coutinho‐Camillo, Cláudia Malheiros ; Krepischi, Ana Cristina Victorino ; Egal, Erika Said Abu ; Altemani, Albina ; Mariano, Fernanda Viviane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3137-e291029c37326e300335499e5aa041a1194168926b823d051ac74d053706cc803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenoma</topic><topic>Carcinogenesis</topic><topic>Carcinoma</topic><topic>carcinoma ex pleomorphic adenoma</topic><topic>Chromosome 8</topic><topic>comparative genomic hybridization</topic><topic>Copy number</topic><topic>copy number alteration</topic><topic>copy number variation</topic><topic>Glycolysis</topic><topic>Hybridization</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>pleomorphic adenoma</topic><topic>Signal transduction</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimura, Talita de Carvalho</creatorcontrib><creatorcontrib>Scarini, João Figueira</creatorcontrib><creatorcontrib>Lavareze, Luccas</creatorcontrib><creatorcontrib>Kowalski, Luiz Paulo</creatorcontrib><creatorcontrib>Coutinho‐Camillo, Cláudia Malheiros</creatorcontrib><creatorcontrib>Krepischi, Ana Cristina Victorino</creatorcontrib><creatorcontrib>Egal, Erika Said Abu</creatorcontrib><creatorcontrib>Altemani, Albina</creatorcontrib><creatorcontrib>Mariano, Fernanda Viviane</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, Talita de Carvalho</au><au>Scarini, João Figueira</au><au>Lavareze, Luccas</au><au>Kowalski, Luiz Paulo</au><au>Coutinho‐Camillo, Cláudia Malheiros</au><au>Krepischi, Ana Cristina Victorino</au><au>Egal, Erika Said Abu</au><au>Altemani, Albina</au><au>Mariano, Fernanda Viviane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2024-05</date><risdate>2024</risdate><volume>46</volume><issue>5</issue><spage>985</spage><epage>1000</epage><pages>985-1000</pages><issn>1043-3074</issn><issn>1097-0347</issn><eissn>1097-0347</eissn><abstract>Objective
This study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA), residual PA, and carcinoma ex pleomorphic adenoma (CXPA).
Materials and Methods
We analyzed 13 PA, 4 RPA, 29 CXPA, and 14 residual PA using Nexus Copy Number Discovery software. The miRNAs genes affected by CNAs were evaluated based on their expression patterns and subjected to pathway enrichment analysis.
Results
Across the groups, we found 216 CNAs affecting 2261 miRNA genes, with 117 in PA, 59 in RPA, 846 in residual PA, and 2555 in CXPA. The chromosome 8 showed higher involvement in altered miRNAs in PAs and CXPA patients. Six miRNA genes were shared among all groups. Additionally, miR‐21, miR‐455‐3p, miR‐140, miR‐320a, miR‐383, miR‐598, and miR‐486 were prominent CNAs found and is implicated in carcinogenesis of several malignant tumors. These miRNAs regulate critical signaling pathways such as aerobic glycolysis, fatty acid biosynthesis, and cancer‐related pathways.
Conclusion
This study was the first to explore CNAs in miRNA‐encoding genes in the PA‐CXPA sequence. The findings suggest the involvement of numerous miRNA genes in CXPA development and progression by regulating oncogenic signaling pathways.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38482546</pmid><doi>10.1002/hed.27717</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-8406-7947</orcidid><orcidid>https://orcid.org/0000-0003-3694-5025</orcidid></addata></record> |
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| ispartof | Head & neck, 2024-05, Vol.46 (5), p.985-1000 |
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| source | Wiley-Blackwell Journals |
| subjects | Adenoma Carcinogenesis Carcinoma carcinoma ex pleomorphic adenoma Chromosome 8 comparative genomic hybridization Copy number copy number alteration copy number variation Glycolysis Hybridization MicroRNAs miRNA pleomorphic adenoma Signal transduction Tumors |
| title | MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma |
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