Minimal Clinically Important Change of Movement Pain in Musculoskeletal Pain Conditions
Movement pain, which is distinct from resting pain, is frequently reported by individuals with musculoskeletal pain. There is growing interest in measuring movement pain as a primary outcome in clinical trials, but no minimally clinically important change (MCIC) has been established, limiting interp...
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| Veröffentlicht in: | The journal of pain 2024-08, Vol.25 (8), p.104507, Article 104507 |
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| creator | Fleagle, Timothy R. Post, Andrew A. Dailey, Dana L. Vance, Carol G.T. Zimmerman, M. Bridget Bayman, Emine O. Crofford, Leslie J. Sluka, Kathleen A. Chimenti, Ruth L. |
| description | Movement pain, which is distinct from resting pain, is frequently reported by individuals with musculoskeletal pain. There is growing interest in measuring movement pain as a primary outcome in clinical trials, but no minimally clinically important change (MCIC) has been established, limiting interpretations. We analyzed data from 315 participants who participated in previous clinical trials (65 with chronic Achilles tendinopathy; 250 with fibromyalgia) to establish an MCIC for movement pain. A composite movement pain score was defined as the average pain (Numeric Rating Scale: 0–10) during 2 clinically relevant activities. The change in movement pain was calculated as the change in movement pain from pre-intervention to post-intervention. A Global Scale (GS: 1–7) was completed after the intervention on perceived change in health status. Participants were dichotomized into non-responders (GS ≥4) and responders (GS |
| doi_str_mv | 10.1016/j.jpain.2024.03.003 |
| format | Article |
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A minimal clinically important change (MCIC) of 1.1- points (95% CI: .9–1.6) for movement pain discriminates between responders and non-responders to rehabilitation. This MCIC provides context for interpreting the meaningfulness of improvement in pain specific to movement tasks.
•310 individuals participated in clinical trials targeting movement pain (0–10).•The minimal clinically important change for raw change in movement pain is 1.1.•For percent change in movement pain, the minimal clinically important change is 27%.•These results will improve the interpretation of changes in movement pain.</description><identifier>ISSN: 1526-5900</identifier><identifier>ISSN: 1528-8447</identifier><identifier>EISSN: 1528-8447</identifier><identifier>DOI: 10.1016/j.jpain.2024.03.003</identifier><identifier>PMID: 38479557</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Clinical relevance ; Female ; Fibromyalgia - complications ; Fibromyalgia - physiopathology ; Humans ; Male ; MIC ; Middle Aged ; Minimal Clinically Important Difference ; Movement - physiology ; Movement-evoked pain ; Musculoskeletal pain ; Musculoskeletal Pain - physiopathology ; Pain Measurement - methods ; Tendinopathy - complications ; Tendinopathy - physiopathology</subject><ispartof>The journal of pain, 2024-08, Vol.25 (8), p.104507, Article 104507</ispartof><rights>2024 United States Association for the Study of Pain, Inc.</rights><rights>Copyright © 2024 United States Association for the Study of Pain, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c309t-7b8fa503aa0960e6a3383685e698bfaa83b2462629b290613d4ba74b6d433d4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1526590024004243$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38479557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fleagle, Timothy R.</creatorcontrib><creatorcontrib>Post, Andrew A.</creatorcontrib><creatorcontrib>Dailey, Dana L.</creatorcontrib><creatorcontrib>Vance, Carol G.T.</creatorcontrib><creatorcontrib>Zimmerman, M. Bridget</creatorcontrib><creatorcontrib>Bayman, Emine O.</creatorcontrib><creatorcontrib>Crofford, Leslie J.</creatorcontrib><creatorcontrib>Sluka, Kathleen A.</creatorcontrib><creatorcontrib>Chimenti, Ruth L.</creatorcontrib><title>Minimal Clinically Important Change of Movement Pain in Musculoskeletal Pain Conditions</title><title>The journal of pain</title><addtitle>J Pain</addtitle><description>Movement pain, which is distinct from resting pain, is frequently reported by individuals with musculoskeletal pain. There is growing interest in measuring movement pain as a primary outcome in clinical trials, but no minimally clinically important change (MCIC) has been established, limiting interpretations. We analyzed data from 315 participants who participated in previous clinical trials (65 with chronic Achilles tendinopathy; 250 with fibromyalgia) to establish an MCIC for movement pain. A composite movement pain score was defined as the average pain (Numeric Rating Scale: 0–10) during 2 clinically relevant activities. The change in movement pain was calculated as the change in movement pain from pre-intervention to post-intervention. A Global Scale (GS: 1–7) was completed after the intervention on perceived change in health status. Participants were dichotomized into non-responders (GS ≥4) and responders (GS <3). Receiver operating characteristic curves were calculated to determine threshold values and corresponding sensitivity and specificity. We used the Euclidean method to determine the optimal threshold point of the Receiver operating characteristic curve to determine the MCIC. The MCIC for raw change in movement pain was 1.1 (95% confidence interval [CI]: .9–1.6) with a sensitivity of .83 (95% CI: .75–.92) and specificity of .79 (95% CI: .72–.86). For percent change in movement pain the MCIC was 27% (95% CI: 10–44%) with a sensitivity of .79 (95% CI: .70–.88) and a specificity of .82 (95% CI: .72–.90). Establishing an MCIC for movement pain will improve interpretations in clinical practice and research.
A minimal clinically important change (MCIC) of 1.1- points (95% CI: .9–1.6) for movement pain discriminates between responders and non-responders to rehabilitation. This MCIC provides context for interpreting the meaningfulness of improvement in pain specific to movement tasks.
•310 individuals participated in clinical trials targeting movement pain (0–10).•The minimal clinically important change for raw change in movement pain is 1.1.•For percent change in movement pain, the minimal clinically important change is 27%.•These results will improve the interpretation of changes in movement pain.</description><subject>Adult</subject><subject>Clinical relevance</subject><subject>Female</subject><subject>Fibromyalgia - complications</subject><subject>Fibromyalgia - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>MIC</subject><subject>Middle Aged</subject><subject>Minimal Clinically Important Difference</subject><subject>Movement - physiology</subject><subject>Movement-evoked pain</subject><subject>Musculoskeletal pain</subject><subject>Musculoskeletal Pain - physiopathology</subject><subject>Pain Measurement - methods</subject><subject>Tendinopathy - complications</subject><subject>Tendinopathy - physiopathology</subject><issn>1526-5900</issn><issn>1528-8447</issn><issn>1528-8447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoPkZ_gSBdumm9adI0XbiQ4gscdKG4DGl7qxnTZmzagfn3xhl1KQTu4XJODvcj5JRCQoGKi0WyWGrTJymkPAGWALAdckizVMaS83x3o0WcFQAH5Mj7BQClWZ7vkwMmeV5kWX5IXuemN522UWmDqLW16-i-W7ph1P0Yle-6f8PItdHcrbDDsHoKlVF488nXk3X-Ay2OIb_Zl65vzGhc74_JXqutx5OfOSMvN9fP5V388Hh7X149xDWDYozzSrY6A6Y1FAJQaMYkEzJDUciq1VqyKuUiFWlRpQUIyhpe6ZxXouEs6JbNyPn23-XgPif0o-qMr9Fa3aObvEqLLKdCcimDlW2t9eC8H7BVyyGcPqwVBfVNVC3Uhqj6JqqAqUA0pM5-Cqaqw-Yv84swGC63BgxnrgwOytcG-xobM2A9qsaZfwu-ABPbh_M</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Fleagle, Timothy R.</creator><creator>Post, Andrew A.</creator><creator>Dailey, Dana L.</creator><creator>Vance, Carol G.T.</creator><creator>Zimmerman, M. Bridget</creator><creator>Bayman, Emine O.</creator><creator>Crofford, Leslie J.</creator><creator>Sluka, Kathleen A.</creator><creator>Chimenti, Ruth L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240801</creationdate><title>Minimal Clinically Important Change of Movement Pain in Musculoskeletal Pain Conditions</title><author>Fleagle, Timothy R. ; Post, Andrew A. ; Dailey, Dana L. ; Vance, Carol G.T. ; Zimmerman, M. Bridget ; Bayman, Emine O. ; Crofford, Leslie J. ; Sluka, Kathleen A. ; Chimenti, Ruth L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-7b8fa503aa0960e6a3383685e698bfaa83b2462629b290613d4ba74b6d433d4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Clinical relevance</topic><topic>Female</topic><topic>Fibromyalgia - complications</topic><topic>Fibromyalgia - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>MIC</topic><topic>Middle Aged</topic><topic>Minimal Clinically Important Difference</topic><topic>Movement - physiology</topic><topic>Movement-evoked pain</topic><topic>Musculoskeletal pain</topic><topic>Musculoskeletal Pain - physiopathology</topic><topic>Pain Measurement - methods</topic><topic>Tendinopathy - complications</topic><topic>Tendinopathy - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fleagle, Timothy R.</creatorcontrib><creatorcontrib>Post, Andrew A.</creatorcontrib><creatorcontrib>Dailey, Dana L.</creatorcontrib><creatorcontrib>Vance, Carol G.T.</creatorcontrib><creatorcontrib>Zimmerman, M. Bridget</creatorcontrib><creatorcontrib>Bayman, Emine O.</creatorcontrib><creatorcontrib>Crofford, Leslie J.</creatorcontrib><creatorcontrib>Sluka, Kathleen A.</creatorcontrib><creatorcontrib>Chimenti, Ruth L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of pain</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fleagle, Timothy R.</au><au>Post, Andrew A.</au><au>Dailey, Dana L.</au><au>Vance, Carol G.T.</au><au>Zimmerman, M. Bridget</au><au>Bayman, Emine O.</au><au>Crofford, Leslie J.</au><au>Sluka, Kathleen A.</au><au>Chimenti, Ruth L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minimal Clinically Important Change of Movement Pain in Musculoskeletal Pain Conditions</atitle><jtitle>The journal of pain</jtitle><addtitle>J Pain</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>25</volume><issue>8</issue><spage>104507</spage><pages>104507-</pages><artnum>104507</artnum><issn>1526-5900</issn><issn>1528-8447</issn><eissn>1528-8447</eissn><abstract>Movement pain, which is distinct from resting pain, is frequently reported by individuals with musculoskeletal pain. There is growing interest in measuring movement pain as a primary outcome in clinical trials, but no minimally clinically important change (MCIC) has been established, limiting interpretations. We analyzed data from 315 participants who participated in previous clinical trials (65 with chronic Achilles tendinopathy; 250 with fibromyalgia) to establish an MCIC for movement pain. A composite movement pain score was defined as the average pain (Numeric Rating Scale: 0–10) during 2 clinically relevant activities. The change in movement pain was calculated as the change in movement pain from pre-intervention to post-intervention. A Global Scale (GS: 1–7) was completed after the intervention on perceived change in health status. Participants were dichotomized into non-responders (GS ≥4) and responders (GS <3). Receiver operating characteristic curves were calculated to determine threshold values and corresponding sensitivity and specificity. We used the Euclidean method to determine the optimal threshold point of the Receiver operating characteristic curve to determine the MCIC. The MCIC for raw change in movement pain was 1.1 (95% confidence interval [CI]: .9–1.6) with a sensitivity of .83 (95% CI: .75–.92) and specificity of .79 (95% CI: .72–.86). For percent change in movement pain the MCIC was 27% (95% CI: 10–44%) with a sensitivity of .79 (95% CI: .70–.88) and a specificity of .82 (95% CI: .72–.90). Establishing an MCIC for movement pain will improve interpretations in clinical practice and research.
A minimal clinically important change (MCIC) of 1.1- points (95% CI: .9–1.6) for movement pain discriminates between responders and non-responders to rehabilitation. This MCIC provides context for interpreting the meaningfulness of improvement in pain specific to movement tasks.
•310 individuals participated in clinical trials targeting movement pain (0–10).•The minimal clinically important change for raw change in movement pain is 1.1.•For percent change in movement pain, the minimal clinically important change is 27%.•These results will improve the interpretation of changes in movement pain.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38479557</pmid><doi>10.1016/j.jpain.2024.03.003</doi></addata></record> |
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| subjects | Adult Clinical relevance Female Fibromyalgia - complications Fibromyalgia - physiopathology Humans Male MIC Middle Aged Minimal Clinically Important Difference Movement - physiology Movement-evoked pain Musculoskeletal pain Musculoskeletal Pain - physiopathology Pain Measurement - methods Tendinopathy - complications Tendinopathy - physiopathology |
| title | Minimal Clinically Important Change of Movement Pain in Musculoskeletal Pain Conditions |
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