Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways

The efficacy of STING (stimulator of interferon genes) agonists is due to various factors, primarily inefficient intracellular delivery, low/lack of endogenous STING expression in many tumours, and a complex balance between tumour control and progression. Here we report a universal STING mimic (uniS...

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Veröffentlicht in:	Nature nanotechnology 2024-06, Vol.19 (6), p.856-866
Hauptverfasser:	Wang, Ying, Li, Sirui, Hu, Mengying, Yang, Yuchen, McCabe, Ellie, Zhang, Lillian, Withrow, Andrew M., Ting, Jenny P.-Y., Liu, Rihe
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61 631/61/350 Anticancer properties Antitumor activity Breast cancer Cancer CD8 antigen Chemistry and Materials Science Dendritic cells Effectiveness Immunotherapy Inflammation Interferon Interferon regulatory factor 3 Lipids Liver cancer Lung cancer Lymphocytes T Malignancy Materials Science Melanoma Metastases Metastasis mRNA Nanoparticles Nanotechnology Nanotechnology and Microengineering NF-κB protein Signal transduction Stimulators Tumors
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