MYC activates transcriptional enhancers to drive cancer progression

We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis -regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhanc...

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Veröffentlicht in:	Nature genetics 2024-04, Vol.56 (4), p.567-568
Hauptverfasser:	Siersbæk, Rasmus, Jakobsen, Simon T
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/191 631/337/176 631/67/1347 631/67/395 Agriculture Animal Genetics and Genomics Biology Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Cell Line, Tumor Enhancer Elements, Genetic - genetics Enhancers Epigenetics Gene expression Gene Function Genes, myc Genomes Genomics Human Genetics Humans Mass spectrometry Mass spectroscopy Myc protein Neoplasms - genetics Proteins Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Regulatory Sequences, Nucleic Acid Research Briefing Rime RNA polymerase Scientific imaging Transcription factors
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Beschreibung
Zusammenfassung:	We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis -regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.
ISSN:	1061-4036 1546-1718 1546-1718
DOI:	10.1038/s41588-024-01677-y