Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism

Abstract Context The body has evolved homeostatic mechanisms to maintain free levels of Ca+2 and 1,25-dihydroxyvitamin D (1,25(OH)2D) within narrow physiological ranges. Clinical guidelines emphasize important contributions of parathyroid hormone (PTH) in maintaining this homeostasis. Objective This...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2025-01, Vol.110 (2), p.e443-e455
Hauptverfasser:	Shahidzadeh Yazdi, Zhinous, Streeten, Elizabeth A, Whitlatch, Hilary B, Montasser, May E, Beitelshees, Amber L, Taylor, Simeon I
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Adult Aged Body mass index Cross-Over Studies Dietary Supplements Female Fibroblast Growth Factor-23 Homeostasis Homeostasis - physiology Humans Hydroxylase Hydroxylation Male Mathematical models Metabolism Middle Aged Parathyroid hormone Parathyroid Hormone - blood Parathyroid Hormone - metabolism Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - metabolism Vitamin D Deficiency - metabolism Vitamin deficiency Young Adult
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