Cyclocodon lancifolius fruit prolongs the lifespan of Caenorhabditis elegans via antioxidation and regulation of purine metabolism
fruit is a promising commercial fruit with antioxidant activity and is rich in polyphenolic compounds. In this study, the anti-aging activity of fruit extract (CF) on ( ) was evaluated by observing the longevity, stress response, reproduction, oscillation, lipofuscin, and antioxidant enzymes of worm...
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| Veröffentlicht in: | Food & function 2024-04, Vol.15 (7), p.3353-3364 |
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| creator | Liu, Yihan Zhang, Xudong Wang, Yan Wang, Jianxia Wei, Hua Zhang, Cunli Zhang, Qiang |
| description | fruit is a promising commercial fruit with antioxidant activity and is rich in polyphenolic compounds. In this study, the anti-aging activity of
fruit extract (CF) on
(
) was evaluated by observing the longevity, stress response, reproduction, oscillation, lipofuscin, and antioxidant enzymes of worms. Moreover, the effects and potential mechanisms of CF on delaying
senescence at the mRNA and metabolite levels were investigated. The results showed that CF treatment significantly increased the lifespan and stress resistance, decreased the levels of lipofuscin and reactive oxygen species (ROS), and improved the antioxidant system of
. The extension of the lifespan of
was remarkably correlated with the upregulation of mtl-1 and
, along with the downregulation of
,
, and
. Metabolomics analysis revealed that purine metabolism is a key regulatory pathway for CF to exert anti-aging effects. The present study suggests that
fruit has potential for use as a functional food to enhance antioxidant capacity and delay aging. |
| doi_str_mv | 10.1039/d3fo02931j |
| format | Article |
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fruit extract (CF) on
(
) was evaluated by observing the longevity, stress response, reproduction, oscillation, lipofuscin, and antioxidant enzymes of worms. Moreover, the effects and potential mechanisms of CF on delaying
senescence at the mRNA and metabolite levels were investigated. The results showed that CF treatment significantly increased the lifespan and stress resistance, decreased the levels of lipofuscin and reactive oxygen species (ROS), and improved the antioxidant system of
. The extension of the lifespan of
was remarkably correlated with the upregulation of mtl-1 and
, along with the downregulation of
,
, and
. Metabolomics analysis revealed that purine metabolism is a key regulatory pathway for CF to exert anti-aging effects. The present study suggests that
fruit has potential for use as a functional food to enhance antioxidant capacity and delay aging.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d3fo02931j</identifier><identifier>PMID: 38481358</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Ageing ; Aging ; AKT protein ; AKT1 protein ; Antioxidants ; Caenorhabditis elegans ; Fruits ; Functional foods & nutraceuticals ; Life span ; Longevity ; Metabolism ; Metabolites ; Metabolomics ; mRNA ; Nematodes ; Oxygen ; Polyphenols ; Purines ; Reactive oxygen species ; Senescence</subject><ispartof>Food & function, 2024-04, Vol.15 (7), p.3353-3364</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c274t-c5070f8f8b743f1cce229265fff37b515ab242aa0df71db97dabba4f2001b2fd3</cites><orcidid>0000-0002-7904-2347</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38481358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yihan</creatorcontrib><creatorcontrib>Zhang, Xudong</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Wang, Jianxia</creatorcontrib><creatorcontrib>Wei, Hua</creatorcontrib><creatorcontrib>Zhang, Cunli</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><title>Cyclocodon lancifolius fruit prolongs the lifespan of Caenorhabditis elegans via antioxidation and regulation of purine metabolism</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>fruit is a promising commercial fruit with antioxidant activity and is rich in polyphenolic compounds. In this study, the anti-aging activity of
fruit extract (CF) on
(
) was evaluated by observing the longevity, stress response, reproduction, oscillation, lipofuscin, and antioxidant enzymes of worms. Moreover, the effects and potential mechanisms of CF on delaying
senescence at the mRNA and metabolite levels were investigated. The results showed that CF treatment significantly increased the lifespan and stress resistance, decreased the levels of lipofuscin and reactive oxygen species (ROS), and improved the antioxidant system of
. The extension of the lifespan of
was remarkably correlated with the upregulation of mtl-1 and
, along with the downregulation of
,
, and
. Metabolomics analysis revealed that purine metabolism is a key regulatory pathway for CF to exert anti-aging effects. The present study suggests that
fruit has potential for use as a functional food to enhance antioxidant capacity and delay aging.</description><subject>Ageing</subject><subject>Aging</subject><subject>AKT protein</subject><subject>AKT1 protein</subject><subject>Antioxidants</subject><subject>Caenorhabditis elegans</subject><subject>Fruits</subject><subject>Functional foods & nutraceuticals</subject><subject>Life span</subject><subject>Longevity</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>mRNA</subject><subject>Nematodes</subject><subject>Oxygen</subject><subject>Polyphenols</subject><subject>Purines</subject><subject>Reactive oxygen species</subject><subject>Senescence</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkclKQzEUhoMoWmo3PoAE3IhQzXCnLKXOCN0ouLtkrCm5SU3uFbv1yY3WuvBs_nPgOxM_AEcYnWNE2YWiJiDCKF7ugBFBBZlWJXrZ3eYFqw7AJKUlykEZa1izDw5oUzSYls0IfM7W0gUZVPDQcS-tCc4OCZo42B6uYnDBLxLsXzV01ui04h4GA2dc-xBfuVC2twlqpxfcJ_huOeS-t-HDKp7F50rBqBeD25S5dTVE6zXsdM9F3pW6Q7BnuEt68qtj8Hxz_TS7mz7Ob-9nl49TSeqin8oS1cg0phF1QQ2WUhPCSFUaY2gtSlxyQQrCOVKmxkqwWnEheGEIQlgQo-gYnG7m5q_eBp36trNJapff1mFILWFljasKkyKjJ__QZRiiz9e1FFFUNRWqUKbONpSMIaWoTbuKtuNx3WLUfpvTXtGb-Y85Dxk-_h05iE6rP3RrBf0COhyM6w</recordid><startdate>20240402</startdate><enddate>20240402</enddate><creator>Liu, Yihan</creator><creator>Zhang, Xudong</creator><creator>Wang, Yan</creator><creator>Wang, Jianxia</creator><creator>Wei, Hua</creator><creator>Zhang, Cunli</creator><creator>Zhang, Qiang</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7904-2347</orcidid></search><sort><creationdate>20240402</creationdate><title>Cyclocodon lancifolius fruit prolongs the lifespan of Caenorhabditis elegans via antioxidation and regulation of purine metabolism</title><author>Liu, Yihan ; Zhang, Xudong ; Wang, Yan ; Wang, Jianxia ; Wei, Hua ; Zhang, Cunli ; Zhang, Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-c5070f8f8b743f1cce229265fff37b515ab242aa0df71db97dabba4f2001b2fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ageing</topic><topic>Aging</topic><topic>AKT protein</topic><topic>AKT1 protein</topic><topic>Antioxidants</topic><topic>Caenorhabditis elegans</topic><topic>Fruits</topic><topic>Functional foods & nutraceuticals</topic><topic>Life span</topic><topic>Longevity</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>mRNA</topic><topic>Nematodes</topic><topic>Oxygen</topic><topic>Polyphenols</topic><topic>Purines</topic><topic>Reactive oxygen species</topic><topic>Senescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yihan</creatorcontrib><creatorcontrib>Zhang, Xudong</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Wang, Jianxia</creatorcontrib><creatorcontrib>Wei, Hua</creatorcontrib><creatorcontrib>Zhang, Cunli</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yihan</au><au>Zhang, Xudong</au><au>Wang, Yan</au><au>Wang, Jianxia</au><au>Wei, Hua</au><au>Zhang, Cunli</au><au>Zhang, Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclocodon lancifolius fruit prolongs the lifespan of Caenorhabditis elegans via antioxidation and regulation of purine metabolism</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2024-04-02</date><risdate>2024</risdate><volume>15</volume><issue>7</issue><spage>3353</spage><epage>3364</epage><pages>3353-3364</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>fruit is a promising commercial fruit with antioxidant activity and is rich in polyphenolic compounds. In this study, the anti-aging activity of
fruit extract (CF) on
(
) was evaluated by observing the longevity, stress response, reproduction, oscillation, lipofuscin, and antioxidant enzymes of worms. Moreover, the effects and potential mechanisms of CF on delaying
senescence at the mRNA and metabolite levels were investigated. The results showed that CF treatment significantly increased the lifespan and stress resistance, decreased the levels of lipofuscin and reactive oxygen species (ROS), and improved the antioxidant system of
. The extension of the lifespan of
was remarkably correlated with the upregulation of mtl-1 and
, along with the downregulation of
,
, and
. Metabolomics analysis revealed that purine metabolism is a key regulatory pathway for CF to exert anti-aging effects. The present study suggests that
fruit has potential for use as a functional food to enhance antioxidant capacity and delay aging.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38481358</pmid><doi>10.1039/d3fo02931j</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7904-2347</orcidid></addata></record> |
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| ispartof | Food & function, 2024-04, Vol.15 (7), p.3353-3364 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Ageing Aging AKT protein AKT1 protein Antioxidants Caenorhabditis elegans Fruits Functional foods & nutraceuticals Life span Longevity Metabolism Metabolites Metabolomics mRNA Nematodes Oxygen Polyphenols Purines Reactive oxygen species Senescence |
| title | Cyclocodon lancifolius fruit prolongs the lifespan of Caenorhabditis elegans via antioxidation and regulation of purine metabolism |
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