Protective Role of NS1-Specific Antibodies in the Immune Response to Dengue Virus Through Antibody-Dependent Cellular Cytotoxicity

Abstract Background Dengue virus (DENV) nonstructural protein 1 (NS1) has multiple functions within infected cells, on the cell surface, and in secreted form, and is highly immunogenic. Immunity from previous DENV infections is known to exert both positive and negative effects on subsequent DENV inf...

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Veröffentlicht in:	The Journal of infectious diseases 2024-11, Vol.230 (5), p.1147-1156
Hauptverfasser:	Sanchez-Vargas, Luis A, Mathew, Anuja, Salje, Henrik, Sousa, David, Casale, Nicole A, Farmer, Aaron, Buddhari, Darunee, Anderson, Kathryn, Iamsirithaworn, Sopon, Kaewhiran, Surachai, Friberg, Heather, Currier, Jeffrey R, Rothman, Alan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Antibody-Dependent Cell Cytotoxicity - immunology Cell activation Cell surface Cross Reactions - immunology Cytotoxicity Dengue - immunology Dengue fever Dengue Virus - immunology Female Humans Immune response Immunogenicity Infections Killer Cells, Natural - immunology Male Natural killer cells NS1 protein Prospective Studies Proteins Viral Nonstructural Proteins - immunology
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