Mpox-Specific Immune Responses Elicited by Vaccination or Infection in People With HIV
Abstract In the recent mpox outbreak, people with human immunodeficiency virus (PWH) were at high risk both for contracting infection and for a more severe disease course. We studied cellular and humoral immune responses elicited by mpox infection (n = 5; n = 3 PWH) or smallpox vaccination (n = 17;...
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| Veröffentlicht in: | The Journal of infectious diseases 2024-11, Vol.230 (5), p.1110-1119 |
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| creator | Grüner, Eva Grossegesse, Marica Stern, Daniel Ober, Veronica Eser, Tabea M Reiling, Gabriele Stirner, Renate Ibarra, Gerardo Postel, Nils Conca, Raffaele Dächert, Christopher Grifoni, Alba Sette, Alessandro Bogner, Johannes Seybold, Ulrich Roider, Julia |
| description | Abstract
In the recent mpox outbreak, people with human immunodeficiency virus (PWH) were at high risk both for contracting infection and for a more severe disease course. We studied cellular and humoral immune responses elicited by mpox infection (n = 5; n = 3 PWH) or smallpox vaccination (n = 17; all PWH) in a cohort of men who have sex with men. All PWH were successfully treated, with stable CD4 counts and undetectable HIV viral loads. Eleven of 17 vaccinated individuals had received childhood smallpox vaccination. In this group of individuals, both 2-dose modified vaccinia Ankara (MVA) vaccination and natural infection evoked mpox-specific immune responses mediated by B cells as well as CD4 and CD8 T cells. This study improves our understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and long-lasting durability of childhood smallpox vaccination-mediated immune responses, including in PWH.
This study improves our understanding of smallpox vaccination-mediated cross-reactivity to orthopox viruses and the durability of childhood smallpox vaccination-mediated immune responses in PWH. Both MVA vaccination and mpox infection evoked mpox-specific immune responses mediated by T and B cells. |
| doi_str_mv | 10.1093/infdis/jiae138 |
| format | Article |
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In the recent mpox outbreak, people with human immunodeficiency virus (PWH) were at high risk both for contracting infection and for a more severe disease course. We studied cellular and humoral immune responses elicited by mpox infection (n = 5; n = 3 PWH) or smallpox vaccination (n = 17; all PWH) in a cohort of men who have sex with men. All PWH were successfully treated, with stable CD4 counts and undetectable HIV viral loads. Eleven of 17 vaccinated individuals had received childhood smallpox vaccination. In this group of individuals, both 2-dose modified vaccinia Ankara (MVA) vaccination and natural infection evoked mpox-specific immune responses mediated by B cells as well as CD4 and CD8 T cells. This study improves our understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and long-lasting durability of childhood smallpox vaccination-mediated immune responses, including in PWH.
This study improves our understanding of smallpox vaccination-mediated cross-reactivity to orthopox viruses and the durability of childhood smallpox vaccination-mediated immune responses in PWH. Both MVA vaccination and mpox infection evoked mpox-specific immune responses mediated by T and B cells.</description><identifier>ISSN: 0022-1899</identifier><identifier>ISSN: 1537-6613</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiae138</identifier><identifier>PMID: 38478746</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; B-Lymphocytes - immunology ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Children ; Cohort Studies ; Cross Reactions - immunology ; Cross-reactivity ; HIV ; HIV Infections - immunology ; Homosexuality, Male ; Human immunodeficiency virus ; Humans ; Immune response (humoral) ; Immunity, Humoral ; Lymphocytes B ; Lymphocytes T ; Male ; Middle Aged ; Mpox ; Mpox (monkeypox) - immunology ; Smallpox ; Smallpox Vaccine - administration & dosage ; Smallpox Vaccine - immunology ; Vaccination ; Vaccinia ; Vaccinia virus - immunology ; Viral Load ; Young Adult</subject><ispartof>The Journal of infectious diseases, 2024-11, Vol.230 (5), p.1110-1119</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c242t-e12543137fd272e193ac48a05a3c5b6353ea32fe413db2c776366b617a04ab7b3</cites><orcidid>0009-0003-7583-6849</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38478746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grüner, Eva</creatorcontrib><creatorcontrib>Grossegesse, Marica</creatorcontrib><creatorcontrib>Stern, Daniel</creatorcontrib><creatorcontrib>Ober, Veronica</creatorcontrib><creatorcontrib>Eser, Tabea M</creatorcontrib><creatorcontrib>Reiling, Gabriele</creatorcontrib><creatorcontrib>Stirner, Renate</creatorcontrib><creatorcontrib>Ibarra, Gerardo</creatorcontrib><creatorcontrib>Postel, Nils</creatorcontrib><creatorcontrib>Conca, Raffaele</creatorcontrib><creatorcontrib>Dächert, Christopher</creatorcontrib><creatorcontrib>Grifoni, Alba</creatorcontrib><creatorcontrib>Sette, Alessandro</creatorcontrib><creatorcontrib>Bogner, Johannes</creatorcontrib><creatorcontrib>Seybold, Ulrich</creatorcontrib><creatorcontrib>Roider, Julia</creatorcontrib><title>Mpox-Specific Immune Responses Elicited by Vaccination or Infection in People With HIV</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
In the recent mpox outbreak, people with human immunodeficiency virus (PWH) were at high risk both for contracting infection and for a more severe disease course. We studied cellular and humoral immune responses elicited by mpox infection (n = 5; n = 3 PWH) or smallpox vaccination (n = 17; all PWH) in a cohort of men who have sex with men. All PWH were successfully treated, with stable CD4 counts and undetectable HIV viral loads. Eleven of 17 vaccinated individuals had received childhood smallpox vaccination. In this group of individuals, both 2-dose modified vaccinia Ankara (MVA) vaccination and natural infection evoked mpox-specific immune responses mediated by B cells as well as CD4 and CD8 T cells. This study improves our understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and long-lasting durability of childhood smallpox vaccination-mediated immune responses, including in PWH.
This study improves our understanding of smallpox vaccination-mediated cross-reactivity to orthopox viruses and the durability of childhood smallpox vaccination-mediated immune responses in PWH. Both MVA vaccination and mpox infection evoked mpox-specific immune responses mediated by T and B cells.</description><subject>Adult</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Cross Reactions - immunology</subject><subject>Cross-reactivity</subject><subject>HIV</subject><subject>HIV Infections - immunology</subject><subject>Homosexuality, Male</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune response (humoral)</subject><subject>Immunity, Humoral</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mpox</subject><subject>Mpox (monkeypox) - immunology</subject><subject>Smallpox</subject><subject>Smallpox Vaccine - administration & dosage</subject><subject>Smallpox Vaccine - immunology</subject><subject>Vaccination</subject><subject>Vaccinia</subject><subject>Vaccinia virus - immunology</subject><subject>Viral Load</subject><subject>Young Adult</subject><issn>0022-1899</issn><issn>1537-6613</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRbK1uXcqAG13EziszyVJEbaGi-KjLMJnc4JRkJmYSsP_eaKsLN64uF75zOHwIHVNyQUnKp9aVhQ3TldVAebKDxjTmKpKS8l00JoSxiCZpOkIHIawIIYJLtY9GPBEqUUKO0fKu8R_RUwPGltbgeV33DvAjhMa7AAFfV9bYDgqcr_FSG2Od7qx32Ld47kow3491-AF8UwF-td0bns2Xh2iv1FWAo-2doJeb6-erWbS4v51fXS4iwwTrIqAsFpxyVRZMMaAp10YkmsSamziXPOagOStBUF7kzCgluZS5pEoToXOV8wk62_Q2rX_vIXRZbYOBqtIOfB8ylsaKSiFFOqCnf9CV71s3rMuGBXSQQwkbqIsNZVofQgtl1rS21u06oyT7Mp5tjGdb40PgZFvb5zUUv_iP4gE43wC-b_4r-wQX_4rq</recordid><startdate>20241115</startdate><enddate>20241115</enddate><creator>Grüner, Eva</creator><creator>Grossegesse, Marica</creator><creator>Stern, Daniel</creator><creator>Ober, Veronica</creator><creator>Eser, Tabea M</creator><creator>Reiling, Gabriele</creator><creator>Stirner, Renate</creator><creator>Ibarra, Gerardo</creator><creator>Postel, Nils</creator><creator>Conca, Raffaele</creator><creator>Dächert, Christopher</creator><creator>Grifoni, Alba</creator><creator>Sette, Alessandro</creator><creator>Bogner, Johannes</creator><creator>Seybold, Ulrich</creator><creator>Roider, Julia</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0003-7583-6849</orcidid></search><sort><creationdate>20241115</creationdate><title>Mpox-Specific Immune Responses Elicited by Vaccination or Infection in People With HIV</title><author>Grüner, Eva ; Grossegesse, Marica ; Stern, Daniel ; Ober, Veronica ; Eser, Tabea M ; Reiling, Gabriele ; Stirner, Renate ; Ibarra, Gerardo ; Postel, Nils ; Conca, Raffaele ; Dächert, Christopher ; Grifoni, Alba ; Sette, Alessandro ; Bogner, Johannes ; Seybold, Ulrich ; Roider, Julia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c242t-e12543137fd272e193ac48a05a3c5b6353ea32fe413db2c776366b617a04ab7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Children</topic><topic>Cohort Studies</topic><topic>Cross Reactions - immunology</topic><topic>Cross-reactivity</topic><topic>HIV</topic><topic>HIV Infections - immunology</topic><topic>Homosexuality, Male</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune response (humoral)</topic><topic>Immunity, Humoral</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mpox</topic><topic>Mpox (monkeypox) - immunology</topic><topic>Smallpox</topic><topic>Smallpox Vaccine - administration & dosage</topic><topic>Smallpox Vaccine - immunology</topic><topic>Vaccination</topic><topic>Vaccinia</topic><topic>Vaccinia virus - immunology</topic><topic>Viral Load</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grüner, Eva</creatorcontrib><creatorcontrib>Grossegesse, Marica</creatorcontrib><creatorcontrib>Stern, Daniel</creatorcontrib><creatorcontrib>Ober, Veronica</creatorcontrib><creatorcontrib>Eser, Tabea M</creatorcontrib><creatorcontrib>Reiling, Gabriele</creatorcontrib><creatorcontrib>Stirner, Renate</creatorcontrib><creatorcontrib>Ibarra, Gerardo</creatorcontrib><creatorcontrib>Postel, Nils</creatorcontrib><creatorcontrib>Conca, Raffaele</creatorcontrib><creatorcontrib>Dächert, Christopher</creatorcontrib><creatorcontrib>Grifoni, Alba</creatorcontrib><creatorcontrib>Sette, Alessandro</creatorcontrib><creatorcontrib>Bogner, Johannes</creatorcontrib><creatorcontrib>Seybold, Ulrich</creatorcontrib><creatorcontrib>Roider, Julia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grüner, Eva</au><au>Grossegesse, Marica</au><au>Stern, Daniel</au><au>Ober, Veronica</au><au>Eser, Tabea M</au><au>Reiling, Gabriele</au><au>Stirner, Renate</au><au>Ibarra, Gerardo</au><au>Postel, Nils</au><au>Conca, Raffaele</au><au>Dächert, Christopher</au><au>Grifoni, Alba</au><au>Sette, Alessandro</au><au>Bogner, Johannes</au><au>Seybold, Ulrich</au><au>Roider, Julia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mpox-Specific Immune Responses Elicited by Vaccination or Infection in People With HIV</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2024-11-15</date><risdate>2024</risdate><volume>230</volume><issue>5</issue><spage>1110</spage><epage>1119</epage><pages>1110-1119</pages><issn>0022-1899</issn><issn>1537-6613</issn><eissn>1537-6613</eissn><abstract>Abstract
In the recent mpox outbreak, people with human immunodeficiency virus (PWH) were at high risk both for contracting infection and for a more severe disease course. We studied cellular and humoral immune responses elicited by mpox infection (n = 5; n = 3 PWH) or smallpox vaccination (n = 17; all PWH) in a cohort of men who have sex with men. All PWH were successfully treated, with stable CD4 counts and undetectable HIV viral loads. Eleven of 17 vaccinated individuals had received childhood smallpox vaccination. In this group of individuals, both 2-dose modified vaccinia Ankara (MVA) vaccination and natural infection evoked mpox-specific immune responses mediated by B cells as well as CD4 and CD8 T cells. This study improves our understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and long-lasting durability of childhood smallpox vaccination-mediated immune responses, including in PWH.
This study improves our understanding of smallpox vaccination-mediated cross-reactivity to orthopox viruses and the durability of childhood smallpox vaccination-mediated immune responses in PWH. Both MVA vaccination and mpox infection evoked mpox-specific immune responses mediated by T and B cells.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>38478746</pmid><doi>10.1093/infdis/jiae138</doi><tpages>10</tpages><orcidid>https://orcid.org/0009-0003-7583-6849</orcidid></addata></record> |
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| subjects | Adult Antibodies, Viral - blood Antibodies, Viral - immunology B-Lymphocytes - immunology CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Children Cohort Studies Cross Reactions - immunology Cross-reactivity HIV HIV Infections - immunology Homosexuality, Male Human immunodeficiency virus Humans Immune response (humoral) Immunity, Humoral Lymphocytes B Lymphocytes T Male Middle Aged Mpox Mpox (monkeypox) - immunology Smallpox Smallpox Vaccine - administration & dosage Smallpox Vaccine - immunology Vaccination Vaccinia Vaccinia virus - immunology Viral Load Young Adult |
| title | Mpox-Specific Immune Responses Elicited by Vaccination or Infection in People With HIV |
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