Association between blood lead levels and unfavorable IVF outcomes: potential involvement of endoplasmic reticulum stress response in granulosa cells

Purpose To investigate the relationship between blood lead levels (BLLs) and IVF clinical outcomes in infertile females and to further explore the possible involvement of granulosa cell (GC) endoplasmic reticulum (ER) stress in the process. Methods One hundred twenty-three infertile women undergoing...

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Veröffentlicht in:	Journal of assisted reproduction and genetics 2024-04, Vol.41 (4), p.947-956
Hauptverfasser:	Shan, Dan, Lv, Yanning, Zhao, Junzhao, Zhang, Fan, Xi, Haitao, Qiu, Haifan, Lv, Jieqiang, Chen, Haolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis Assisted Reproduction Technologies Bcl-2 protein Birth Rate Blood levels Cellular stress response Clinical outcomes Endoplasmic reticulum Endoplasmic Reticulum Chaperone BiP Endoplasmic Reticulum Stress Female Fertilization in Vitro Follicular fluid Follicular Fluid - metabolism Gonadotropin-releasing hormone Gonadotropins Granulosa cells Granulosa Cells - metabolism Gynecology Human Genetics Humans Infertility, Female - blood Infertility, Female - pathology Infertility, Female - therapy L-Lactate dehydrogenase Lead - blood Lead - toxicity Lead content Live Birth - genetics Medicine Medicine & Public Health Oocyte Retrieval Oocytes - growth & development Ovulation Induction - methods Pituitary (anterior) Pregnancy Pregnancy Rate Reproductive Medicine Signal transduction
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